%PDF-1.4 %âãÏÓ 1 0 obj<>/ProcSet[/PDF/Text/ImageB]/ExtGState<>>>/Type/Page>> endobj 4 0 obj<> endobj 5 0 obj<> endobj 6 0 obj<> endobj 7 0 obj<> endobj 8 0 obj<> endobj 9 0 obj<> endobj 10 0 obj<> endobj 11 0 obj<>/Height 817/Type/XObject>>stream –MC #�r>GDr#Äxâ1òùty D <–§7ÓßÿÿùÞ±öc%BœÉPs¦O‘DqŸ1›òÿéÿª xl¥�ñFç�_G¼ÂYûµ§ýRn½·ÿ˜GŒÚ#Æ 'Îãì=v!nÅ1L{[ˆïˆƒ"  ú…Øxˆˆöþÿaý¿· x5HAÆÊÚÖÞGl®²Á6PÚ+im @­„ VÒ ØH+ �°Ò e Îóp� P™Å¶‚~iì4�ïí¤F� Utƒ9—ŒÙöfósa �[8°˜A„ô›H$ƒa#C–íÜ÷ž“i8 VE½7MÖ•¤ñM„Õéñßm"a¶Ƚÿ¯öÚH"=‚2!ÿþé};aWß÷þ�¦Â]7‚µõµÁüåO ´»`�[KºêÒµºí†ØI+· Å6ÇÆÅ1í†i{à�Z¶4Ó[†ÛA4[Ä(ˆÏ¸ °‚ Þ �pÛgsaÒ"4oa @¸a·ù�!­ AvsëÂ ÈæØ‚Û¤Uì[ (a·”-lÎM†Uè3u&Û×Ó ‘ 8â(a·û $Nð@¡†umÈ‘ÿ¤§ö`�7[a«sŸè^Ka íÿú Dv ‚°öÿæ=&ð@¡‡·ÿá"]”m‚&ÉÁ½¿÷9è$ÂÄ+oûµÒ!’V ‚†ßöÅanüÙ Ûpá„é Ÿ 0ˆ¡XÛH ­ˆF„ °‚z«"…{KIÒÛI°“j@Ë ²tVPAZÄ @²ƒiM&]†!úMÉ‚ÚAˆ@¾“`�d¼½š—eý$°@´ÛÓXA6 6é%‚Ãa¿ÂBa±zIà ï @»}$‚ †Tý @¸a‡è…iÃ`öª@‚ì0m:ÒM”=·�åBUH ¸aƒi7ú@�pØ}ô�"øH.Ã^ÿAà iµI- @¸oï\ �ì?Ò=ÔP \0þ0I&ˆpÃCŠá †øI ]†ÏúP@¸aýP \7ô¥!v•P \0ÈjúH \7oÂP@» í*¢œ¸aÛ*Û¶…/†µA¾vêÃá»è7Ø~u$˜|1~©öùßD`'ú’øOú< É�`õú í ðŸœÑ¡^vjŸøó»ˆä�ùïäÄTGú~?7&z³¾A†ƒ/¢í¿äü„!†‹ô“¿àˆùÐ >”ïoÿ!A›ýwÿàþÛ_ù 5‰qt«ò ÖƒñhqÈ&ì?<Ú/¼ãŸz?ÚS9ß;ü7ÿ?Ûãjf_‹~‚#øøoíd�Û;_ý²Ušg\¡F æà¸Bä>Þ:£Ckþ‚ �þþÿÎGóLàäXy g ¾`SbÿßÖöÿÿ‘ì-ú=æ» GÆ·ÏmÿûýëÁ‡_ï¿ùâÿÿƒë¯ÿïÿðÿïÿÿÿÍ+ÿÿþý’ïÿ÷¯ÿøí�Âý¯÷ÚÿÚÿÛ0 ÈAì ŠŠÿcÿ¢ v�ûµ_ÓGÿœ#²Ð\DqÊ}|ìL0ÈWäKúMÊØÃvì%Òµ)2”m�b§e¡Nã5ŠkÌzA½"¦qÍ~é1„‰X1zÆ~þ–" »ÿÿ§6‚’`Åüáž3ÄpS™‚7›?1œù'T ¿ÓM4�éÿÿR@/y!Ò>4{hüà´§¿üÖô°‘°]ñ_cÿ¤ßÿþJ½�è†��¼±ÒÃŽ›ÿççý7°ÿ†6/°¥ÿ·ÿì=ôCì¯Û›G9íÿÿÿì^ ?Û‡ÿÿÿõØkä1[íç2ÿg>6×õ¿ºØƒ±¹66+ÂáÒø¬/°ì°ÿíª²ú¾˜ø£°ª<3ñƒw+�f®ú–õ ð¿ ÒʦJ3®He?Âú�M¿ ¼Âïÿë×þ½.�6— Dý¿„þÙà¦Ùócïóc63Äo9›>-¡érc¤�VžÅZKiús'ÉòH»ýàš@ƒp¹óÓóãžè×ôks°¤lPƒ2S©×Ý¿úÇÖÒ_é¿Æµ;´g~ûh/$ôü~ÑÝ—ß‹ÿöSÑ7O÷¶—„¢ÿóbjÇÿì:û¤Ù„^7žEóŸžßa¥á)ûóŸ£_¦›Jtðo¤¿Å„Іðˆ¸ö ÂI_ÿUï÷×ù„”‹ ùœ·rÜ·~Œÿ œ'Â[ûg?UÛV)ÎiZ§ù�ÿÓOUÇOáˆFhpJ¯¸¯bø¾?cccôÿúßW¼Q-™ ’¿m{&ëd£†·j�µÆÿÿëžzß𥗃}ÿÿÿïø," ,Šºßÿÿÿþ9VVȳœéöÒÿÿuK‘í.kikÿÿÿÐnìSWÿûÃPom0ƒUûþÁÿFÇA¾v%¥¤æÅÃvÎÕ¥úpD1²„*ÿ $´¢†ÁBd"¶ÅWÁ¤(±Ù«Ö">‰P ƒwý´`Ö›ÿé’GRAȼNÃ6g ¹vèƒ –Œ;í#¼ D{OÃPÁ¥Ðm…5ÐAØPƒpS߆(u�ÿ}}� `× Ö‡¡ì> ÃKÿþÐ0ÒÍ4[ëçFtA¿ƒ &ÕïïðIœküæÊe7 ÜŽˆéÉs-¹×Ró±oÿüìHŽË„"kúëþxÎUùÿüy �™áþqo馿þxÜøÑí£_ÿÇ"GÞ¿ÇóQZ_ÿçÙ5¿ðȃ”9p¿Öëÿ8Úä¶uÿÿß}ûÿøðÂØI°¿üì[ئ)�ÿ��ŒDG)Ã$/ýÎÊ—ôx§Î¿ÿñ¥ïÿÒÿÿÅWôÚM¤ßò7~;Ö�aïÿäB9¦Á²{_¥ÿÿ©çC8?o5ßÿNh�"iÿÿÿ¶—†ëÿò!HˆèþGÈùtG C¦¿ÿÿãùÐ|þ¦wÿ†Ùéÿÿ˜kö’ÆÅ?ÿö¸@�D—ÿÿúý³¿k¥þþ�-ŸÿÿÿûSû�O›ý¿ÿÿì("?¸j¿Ø"?„gz$˜¿Òµm/ù“ã9WJ_ìf6*?úäJKÕ-ü0„0ƒ ÿ^¼ñÖÛñÿ„¶+�UßÿÉ1A…æ��Ûÿ}-ÿü�ÿ·ÿÿ’Eµÿþå;$£$EVzÿþ/«±ÿÿ;+D{mÿ^ ˜0¿ÿÎÅ·„¬_ÿ󱿲&$'d�ÿÿ�)Ä»h!Ûÿÿ¸M…·ÿïž"�7MÁmÿòLO �ctþE—ÿ޾?Èßûy9ž¿_ÿ9RðšþBaü�C# F°ÿõÿý·z=Êÿ�'ÎaU�üþ. Dyj¿ÈÀŸÿ;+0&G Bˆë¯ïÿíá€aˆÿÈKÿÈ t›‹¢éˆ d-–9ëúÿöl‘-0Aˆ Ec„xüùòLMza5n¿÷ÿþxïM„ /ùÒ‘¿ÿý°—ÿÿø÷à†/ÿÿò=�Çùýš‡þ?úž-¦4×ÿýü0�ä’ÿÿþ4)‹ ÿÿþ©†âëÿÿÜãeŽeÐ…à×ÿÿÔ‘‚:8AœpO_ÿÿØLqMÿÿþÆš|?ÿü“;ÿÅÿôv6MÚÿÿò7Þè‚#ëÿÿèìWa¤Ã 6—ÿÿ³°?b˜0JAÿæ£ÿñ°˜¦BŽÿô�êx Ž8 ÿôoÿ~µ"gó‹ÿÿÇýyÝb�™²ïf§ïÿXˆ�Úi%·ÿÿç�ÏÔlp¡p~¹ 5 À+þ¿mßá‡ÿÿÉ1.?óæc#³ ÞG{¡aÿÿþ¿õâ./µã‘Óÿò7ò¶ õîh.2á¤ážÂ:½uuÿÙ=•x®©®¿ûŸNBôc?ý~»þ›ÿ"Ù@Nþ¿ùدó£ÿúþ–ØKÿÿÿ_ûèØÿÿ��—ÿÿõúãÿó$gìéëýÿÚM¯è/ÿÿÿ<uþÖÒýÿÿô¿ÿ�ø¦+ô ÿÿÂ#ùéOäë�è3ÅéçpƒÖ?ÿý/8aùÚ^"#ÿ_öûÑŸHÏ‚ç�ÿëü“ô©¶¨7\ÿÿÿ|}/ÿÿÿäot¼‹ùö Çòcÿý÷‚õÿæ×¯ÿþ*{ó£Él«ìèëÿø§KìòÿÎë­=ƒõÿûÿºøý öý_ÿü0½¯�Šÿaì?”ÿÿí1Gá±^v4?ŸœoaøýÊåCÝ&ö?ÿýŠÿå󙌎eÙ¼Ž{›ÿ¯ÿ;ÿrÇ•ÙÔ³©þÿôº¦kÍž÷#?�ù&'<~?§ÿü‹e1ÿän2%_ü.ÿ¦ÿô‡ÿÒ|:?ÿÿ¢7ÿýÿÿÿÛ¯Ð__öùãÿÿ¥¯èãÿün¿½´¿Acÿo’ÙWì/öƒKôÿ¾}‚}‹þ!1_�ÿ~¼DDg.Gÿ÷²{*øÿýÍÿý¿;ÿÿýÿãÿ÷\ìhÿûÿÿþÿ<ÿí¯ÿþïÿÿíüñÿÿ™,ñÿÿÿdãÇÿÿ }ÿߟ`Ÿÿáÿÿþü–Ê¿ÿßÿøÿñ‡ÎÆËüì˜È�äàÝÿþ}–üéá¼ìWÿÿã��þQ‘âñŒº#¿ÿü‚ �qGÿiú^ª~›ü_<ÅÿÒþj�åxÇÿÿ¿ú @¯ÿÿ×ýá þv¯ÿÿþiüñÿm/ÿ?ÿ«¸¯ó½6+ûÚÐÿü¬ð�!|ûÿÿô‚&"?�ÿÿt@ˆ�ÎÆ‹þ?úH/Ûÿÿô_�ŠÿãûÒJ<ìl¿ÿê“Zÿýô�Y{ž?ÿî”Wÿÿî’Pˆÿÿý$’ÿÿþµüñÿ^ßIy�ò ÿ�í¤¤ {Œ•' øÿZ†ÞÃèûÒI‡xR6÷´’ 2<Þ�Œ¤7ÿÞ”6zX"2Àÿ÷¤“ 0óºêÂ&¤ÿï¥A†ÞiX MÿíµH0Øv´&ÿþ’M†: ÖH÷n”0ëf+g_þÞ•»X"=ãÿûj�l?©mÿûÒI†ä{×ù×<Ïd,/ÞéCa‡n�7ÿåEÿt’ 0ÛèkíéQ'ý»J˜l6ôºÿïþê�a†é7þ�ódxÓ6Yü�#yÏí·J °Ó ýé„ôøÓÿݤ“ †„S¿¥=ç» <5½~î•a‚#ð Kïññöý­ºûm¤�a†Â'¸#ÿ¤úÁñô+ù�â�1H{²`J$ ‚¾ÿœ¯g…ÒÂ.ÃEÀaÝõK�Ñ¿×þ’GÃóÒ·è ØAÂ/Ÿm¹÷’°‚4‡þ8Ñò Ûú>I¸M ›öߤ”4–©/§óùïþ>�'I¾÷éU ­W÷ím{_Õ­oo~Û~’RNK­¦-ŠmŠøþ�z¿múIa´õôì·µ´îÉ¿þ­_¶ß¤» &—KÎÉþ¾Û~K ¤Õ*ÿþÿÛo bè$°Ã7„�õ^ÿÿ¶ÃÂ$iÅ7¥ëþ¿ÛoŸ‡„‚[PD}õKÇþ¿¶z < ’ÇÃwKÿß †“zIipˆûª_¶“«¥Øl=ÞA—}“µî’òû[¦×¶=&ð@‚_ÕE6¯%£ÛI°•×aƒ¾F ½¾öÒòR.à 0Òa„¸aƒÑ>Þuñôc “„‚#�ÝŠ SØg]BÄKˆÚR`P¶ x X0A„\0úO� \°”!’âà©„Luä xˆð`ý[ ã:„¤g@�ðA!y&/Ã"ç¿é3ù )ÀÊlÔ0…x"9ø1ÿ_T”…© ¨s@‚ò0&Cþ Ó¥‚I$a¨0¼/�¿üòñÒA$‚—Û3ä�ÿé|RH$�]ó1ÿ·¯ ’I,|/îÂú $¨ø‚ÿb—%´�‚%\…_ÿuð‚ $—· _î½HS„öÒä1„N"aˆ˜B`$Žx àC‚‘PO턾ûÿ¹ø"8ÇØiÿþÿ Cþ®G()Á[^U�+©fB_ .Šú /øþS�ÿø ]ò�÷ÿÁÿù\ÕfÇ×ý(‚̃0VÈqËsŽaÌ9nh;–3…�¥�à 6ÀÆ”9±g>ÒÊøP䇠—üȳÒ4ÿøPDqÿý%ÿÿ¨ ¿ÿœ‚!ÃÿþÐ#;ó-@ðÿü­ÿ§ÿÉrAœ"HH?ò3Ÿg‘ <5ÿîi„ l5ü?�kÿÓTÂd Oð™ÞYÀ\øpålWÿøá’Ñþ‹Çé­÷üì'öšjú þ}3ëG×ÿÿÿ¯ö×ÿÿÿþÓÿôSŒæG"än#™ìöƒ63™ÿÿ×ÿß�ã­Tâ./ôãÿÿ¿ÿßïÿ£[—ã.߆68/ÿÿÿñÿÓÓOOý=ÿÿÿ¯õzþÿ_ÿÿÊ3Lë�¼º<ˆèŽ‹¢÷ÿÿþúÿø¿ÿþ‘Ãÿñÿ(_ßÿÿq÷>ÑÿÿîŸÿÿÌG÷ýÿÿýï_ÿïâ#ÿü¬ÿþÚV½}kÙïõÿö?û -¥ü0¶½¯¯ðÙJ_ûÇüTpØ­¦£ÿkÿ°ƒ ù‡L›Ü5B¯ý°—þ""9‘,?ÛKÿÿí¥ÿõý´¿þÿ¶—þõüî°éãÿK�µ��äpÐ\#£hŽ‹™‘ã ÿø@ˆltC$Æýÿ@ƒþ?¤ÿ�ãþ‚oþ}Šþoÿþ“ÿúoÿþ‘ Gÿÿ…» ¿ÿúA ·ÿÿIßÿÂGÒ ÿô@Ã_úKM·ÿiÿARÿýÂ]7ÿßýû{ FÁ s9C�A××ü%¤þvc+Îûÿ�Pÿy˜¯¡ÿ_ëÿÿÊÅþ?ûÛÿÿÒþ~¿ÿÿoëÎÈ �UûþÛÒÿ¯ì?¯�r¯ßðŶ¿ÿÿvÒKÿ�áá…ÿÿí†ÐKÿͱO튯ÿþàÁ/ÿ_Û¿ÿý¥ÿä3.ˆñÂòèŽÈè¸B:#‘̹ÿm/;á?ý<ÿ†Òøüû?û /›ÿÿØa/ ÿÿÿ  ¿¿ÿÿ† ¿Ïx�ds43åÿÿÁ…ý‹ §ÿÿÎá‹ì*6t]¹nÑnÑpÿÿúmüVýtôÿü ›û§HUÿÿúMüó`¸_ãÿÿé7æ`WæÂgÿ6Ÿñÿ&ü©æÂîˆÇè�ÿæþ?ÒoÄ{›º7Çÿú?é$½/¹ë?ÿÿý]{_´›_ÿÿÇìq_·ÿé‘�Ø"=í¾C$3Fÿü®Uö‡ÿù×'™ÇÙø’ÿŒ~ýëÿÿëÍ7ÿ:äÿÓÿÿÿßûÿþwÑÁ„Â8?1žÍåÙƒ9Ïÿþëéá?þ-8¿ÿÿÚÏŒ0‘và´¾\w'ÿÿtúü'«_ªzÿûý ýñ_UÕù˜dadt\ËÄq ¢ìº#æóká‘ó®]ÿýæcÐø_ÿú!’â"#ý® ¿Í¯ÿþ`³íL�ä ÿ˜X¬(rˆ)Êr ã™Î9Ç ƒ�£’‚ÿú#ÌGÿÿý‚!_Ñ\Ÿ÷§©»¿ÿÿÿÿÿŽ:^Ïÿõÿÿÿê×µû_íÿÿíAdrr ¡Í^(s¹PZ9^T\S”9C˜åyT)9WövŸ_ÒI$’ä Á]â?ÒI$’ÎÉbP�NˆùÑs#�àHv€S�qW�FJ‘¶{#Ä|¾GˆáÿI$•-Æìi�Jp®¼Zϲä2CT~’I$—ëÿïä4 �I$’KûþƱ�‹Óhq£+¤’I%úÿí§¯x¤’I.;ãŽ1úÄDF+µOãüxãß\Wß}=ßO_òܱߖ9nô·éoÖß­úߥ·¥¿­úÛéméoë|qã�ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ2hˆÄUä�ÿ 4Ìv¤+ÿÍÌGÿÿ†ÿÿûÿÿ6�|ă8?7—3™ŽG°ƒÿúhziü\_ÿýô\pÂF¿ËŒ¸~Âÿþ‚~©¿¦éýÿÿÿ�ÿ·ÿÿÿð_úÿÿëÿž õÿÿÿÿÑÿÿÿÿÿú7ÿÿþ—ÿÿ÷Zÿý-µï_¾ÕÿÿÇÛüTpÿð·Ûd‡ýtÁÿþdg†DDg€A‚×üÈ’Çý¥ÿØÿû_üGÿÿÿÿÿÈærœöqÏ…9NqÊò‡* �åXåùXÈ´K jÁ=< É|‰¯þ‹Ç«ý=ñüïýoþ.gÇœ#3#É6c? ÌeÙìúOé\Zzhk¡ziÿyqF·£[FŽõ°¤áøa}n›§éº_ôß×éü}uÿÞ¿þ˜ZÂûÿúïÿâüØOëµ½ÿÿþ¿ßõ¯ÿôiþlÿÿÿÿú¿KÝ}´¯õÿûþ½í«i}¯õ¿�b£��‡þŸß§ .éØ »ˆag†f„ó-×ñWÄDq݆ûý„ÿÿ�j�äsqÏÇs¹NTÎÎgȪJûËAÑô\Èñ#ÅÁl2¥ªL7€€ endstream endobj 12 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageB]/ExtGState<>>>/Type/Page>> endobj 15 0 obj<> endobj 16 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>>/Type/Page>> endobj 19 0 obj<>/Height 1305/Type/XObject>>stream ËLª•ÆôéÝn·[¬Ðè·íÂYdXDÂ#¢>GFââ—pÈØt³²´]Éò>G �0Na¦Ý)0h=º\‚Øqȃ‘¹1ÍUeºL†@iCHr‡0äÇ8åPçã˜r‡(r°¡Ê‚œãœsÙC Üf6+t6¶á/n—·KØtŒ–Ù¨Éÿ233H§‰&!¦Ý#³B#hJS²ˆ ÿTêðƒVè š Vô×Ög­è”<7 ZsëÑú%�?ÿýû]+~’ÿuù‘ /Þ·K+zIW﫯í¾°ÕÒ¶Þ’ûo¬4¿ë÷°­¥¥ 8a#êAµ^6?õt½�ŠT­±¦šÃ]Ý«ý(÷dWa¬ ­µé1[²7a…_ÓTÓ ÁJØaí†A‚0„DE(aˆˆ�ˆ¥oÒ·áoÒ†¥oÒ·å}Q:9˜Èàx ­™¢­ €Íˆˆ‹ CdàfºVÈ-ƒ0ä äzVä2A˜rÇ)ÎåPå9ÜîPå{;•Ç‚�ÆR·33! ?Jßc&Ã]_…~¡ö¯�øÔyhu¿ÿú�;*Ž„u"nªa}4ú¢våß­:Mð©6“õþú&?÷ð¿¬ué|vþû¹7(û_ôü�ú'ÓúA¿_Óü³~ô›~¿ýd°!gSÍD_ÿÕuÿ~šÔ/þ¾³r~ÚOZ“jð´«ïµïE½uí‚L0—ð¼Žyæئ=qââÒûL/Ës¢c%îí. ÁzgH0ƒææ‹Æ¼GDWú¦ƒÚ°Ó×ë¥Yqšø¸º_ìBè&Òoí}\*ïÿßùcÖ¬|ÿ˜ëõdØ<¯q/BÑcþ¾•HË«æE×0@ǯÂö­¯ÿUA§¥Þ⢎«ÕQw›:]­îÕý_U¦Òo]Œà ­ÿáWÿKÛWÌÿÇû ›ß®ð´gÚ_?û×cüÚ¢Gøô¶’Î’k|ì­Ù©ëu¦—þ”™¤Á}“jzZ.Úû{c•�êš^’ºt¾º%J5Dá¢pÿІ“ixk tB ›A?øHDDxDˆ ié½4ÿè$áUÕúüë=$d�7áÑ1ô×ýýZÓ‚XAªÔkµqö$sDX"¢0¿º¯ãö£æ þü0½¯„ú¹7×'#B)Æ"")ø¿ºÉ·jA¦œ’�Žßâ:¢nÑpÑpÑc˜vNÃè?È`Ù*°žƒÐlÈéÁ´÷×þ›JëQDzvNMÿ¢Ç�¿ítmÿ~Y¿k¯ºþxtïÿøá}ŒÊë.ùˆÂ»ÿèpKV˜ˆCôÿߺýµM¯Ýÿúø7 QvȲ }ϯi?á¶4�Wôöµ·ÚVMûÛdŸOßéØa%ì$ÃZßü&v*'íŠKb˜«×û U˜‘ ÎÚ°#ûU´×笽ôÄB(!`çiÀÇ\!aí¤ÚV­cG@`©�ƒ—|Dµµa…kÓ%@_ÿûÅا"'¢(þ½Ó[A>—^”]¯á>A†à�ƒäÁ5ÿ it’wÖNÚZU®�‡Èvê`ÅÂ×üz_Ký(NºI~.<“u�zÒþCu×K×Jœ%ª_ü7õÿªU ªý.ÐZKþ¼;×ÿI –’éaéa%Wè/ ¢ïËÝ)’ÑéFÇ¥¤–”CñàÛïô’Ký­+ÒÐOx/È8Ÿ¯ÒI/öM­iïH"#ø:ý× ’HDDtA,QÉA=;jq\Œµô’KÚý{H^`®ßé$‚|0«äôƈ�ý/R8² âqoì Azöüi¦¢""ˆ]üW¯à�ÃXˆˆ„ ¶ÖÂÁ‘‚ƒتÑö§2[`ýAŸ“Ô8DuᆈˆÑ‘˜¥â¸°H0y’Ø(0w�Ö �‚V ‚ƒanb8 PÚça� �BÉìË�§‚Âÿ–Š`�Bç`w!w?@�Aüì@äG&6¼S@¿� ˆü(@¿;€/-òs1 `+d*$C; PÌ#ÔJARCP/DPR'A ü‹†g�ÕH0òFäéU¶‰Ãò4Ÿs8Y µuA6‚~dH0ÌŽ². Õæ-ïMþH ßÉ¢. “«¿g(Ž»Îê|�h˜÷ÿä2Öñ¿±êþ@�»¿ðµõä.ÏþØÿü¹*~ˆ.'KÆ=ëÿúÒÖAöã¥÷÷Òÿ#‚5ÒöDp£-Æ—KÑ{ ä/*-/à i_��×`Á-.—დ«ü1ZWýCÖ–vàÈÊ(�øÇدûXÎÒ�`²oê"·û×ÿï×ù7õïõïÌ«¼·GbJvU<®èìI)ØÖv5&Ÿ4v5¦šKýSO_ÿê‰åÏÿÿ MÓÿýk§ÿ¿øUuÿÿü˜þûÿÿðºëÿÿð¿¿ÿÿ�½?ÿê½}\ì.�ƒœrÇ,qÿ³Žˆñq‘ÌŽ°8ïï L ?ù`iS”çò‡*Ê™PRå_üƒ8æ‡ã”9C”9Ü¡ÏÇfw®¤Ü§ÿÿûÿu×ÿþÚ¶¿ÿûi6•x¨¡í5pÐjZ!oÿü|´GÿÿÇËDÿ;*ˆÆP/Õ×Lj¨žaV›ªÓÂë“r¥“‹ýá:]¯„µÿJ˜a/®ÅURº¿Z �ƒ�]ÇwJ’z®�734Bòoýú|˜ù6uÿáå¹×>>Ö½êº|Œw÷ªÌ ¸ÒïUª°×ó"ÌëŸtª©?Ø®E!Ò¯„[üµáÅVbæZ3òòú /uZHuâÄGðª¿]‚ ù6E�‚#ÿ¥¢ñÃÿµ¥åìŽô¶�”?þ:\Cˆzââú^½Þ’vÿ õÍmoˆ}ø¯K íú!¬ŒŽ‘ ÿ^¸ãçFnPµª¯ªÒMßjöÔ.š~ñý°•„•RKߘY!/±G¦0«þöqÊ$Õ?ÚØRǪ¯‘H“`÷:÷ê" !Z,zGÐ"?ðo]°‘äÃHG­+Kÿ¿¬V—U_ßðÖÖºZ\ì¯##¡}â"#¥­¥ÖÂÿ­*[�E"@Š©ÿëééÁj¨�þ‡ˆhCBè0ƒUA7êZ—ïDXa 5öýo:D†KÙg @ØUKá—eÁ?~“h Ú&ôXý…ÄQ6þ½< õ×CÖ[ÒSçªøŒ-|åÖÄWÿñÒðAõ™íˆ�ô½>½…òQu¡|ݵõäxäÙ/§a¥étÝ–OG\ÐÈÃ"~nLð1D2†ýtúª ÄBFƒÃN¾—\„é¦Ñ 8¿ô Ýædª¨ÙEãkÊ{ÿù7ü*ï_ü}ÿÕjý9ˆ×þ׿|ôüî°`ì×ùÿáiR¶¨Ðx~¿÷¯,Š…‡ÿšäq`£í]Z{–�._±_ÕÚ ÐIÊݘ¿íc¥�Ú7?�V[\|5éaöÅdr©ÚÌb"ÅüC´°³ (q×Éúþ ‘t\6¿ðy7ÿsà¹3ðÓïùÖÒoˆã;ª�Š®"?øka @»�À) Îä”Oö(äÅò ‚ ó® ôÖá(rc“":æâ N ½0d&Õ?µL @„DGÊ~ùˆˆˆAFk kÁñ %Á�PçÆ1Â’`À�ðApcäT`�d°&ávh  a9ð#ËpTAÀ�&AC ƒíR[Õ�sâ„ ,ªgô_õTa ¡ÊsŽqÑZë�9ÈŒŒõYwEÜ‹ÇHø§@B$�+«ÿ¤Ú¦žª‚n›Õ?®$ ÕW ¿ë¢á†wI„\¤?ÿUæ~ÓøU â΀À Ep±ÿP¿ÂÑž+¤«MäŘ“÷J«Ž¾Æ‹¯¤ÄV/í… «éi5 E�ØAž  ôÅ*,|Ãõ­SµH48 _¥Æ´½ÒÒEÛÒÿD*|0¡k¯éiSéi$™8_ÒÒýi$ßéa<(ä�×_Ú_¥¤’4ÃÁä€cK_ô¿PA„¸T3!u##]®— �úu�]q¥�ðEºt\ëž½-.úIµô©®ZÂÿ®»2ι5�ѳða,é$¿·.¢ì×ÿ]yr-ª§ý±^—ôÖßüAÄ*ª&;ÿkä>qÿíÿþºÂ ˆˆ�Úápd áÿýT.þ½11ÿÿçgERUE�¬®X ûoüŒf·©Ö(‚w­wEr�cÿÿúª ÇE¼{ W9{ÒÿýUQwëØ¢¸�$víÿUZoKò¸'‡ÿáuIÝ}•Ôvšˆÿæz£?ô¾l®œ„GPïˆ� F}×¤àˆ ÙfÎ,/\~ô ýÊçâ=Wéàˆ ¡Û¥v—¶ž×©^KãS¯ùRÒÁÿ¯²(ëöÖÎÖ\2úµÃ[ùþ+;¨ ”��B?øjdr'_|ê—Âû3éyÖïùh‚%Å—³Oö—\ƒú «üÍGÈhÙ® —þ›\�ç®Bƒ/ëÃ,rféòܸIy…&òÞ°|‚ÆÁ§ ™8ƒêainGu¾µLœ&[Ì0rþ’êž[Ø<28„& Ñ'ynjÒ„«Ì’�râá…T½2X]-WoÉ@8ð–aõåsVJÁÙ1Ê¡Êr�Æä2ɹ7®>àˆ#)&Ü-.³°¶Ä¹ó¶ÙÁ8¶ÙÖ¾·É³Ý0µþ³åÒÿÈÀ³æÖº°ÀÄs Ã"à^¿�Â#¢èŽøbF8_�× /Kÿ2½xþ? Àÿÿ’ZúãøM2 ã•Á2ZŠæ§ö¯™i×@‰%ú?“_ÿÿÿþvW‘Œ�?;ÎÆó±¸ìj®ƒÎƳ±¸ìjNïê©÷ÿýU¿ÿÿ]ßÿÿ »ÿÿõZÿÿú&ôXõ¿ÿÿ]×ÿøZû÷ÿüt¿ÿÿýÿ©Û£ÈÚ4@Š2>GEÑ„GF �—Ž›ÒëÕ2(Èàl N½ñK®@” ŽAÇ,sXåS•åA[ ë¾Al5G&9C”çsAœîVðæâºõ“rŸÄÿþ¿­ýÿ‘Žè¯Û_±_h›–/µqÿþ2Ó 2‚)ʃ „éÝËD$l¢í£g{¤êß®žŸŠÐã×0èÃá%4!ébî7'ŽO´Õ]==ë®ÞîòÑÿòl/V·Ì‡Î–Úß­BV­¤ÚU ÛÆsc¬›½¦¶ª‚ á„T]'ý>®–¯¯É¹OKþ¿~¾º_yo«$2!×è�áaKítiëê…t^9±�š‚ô þab QéÒußáÿßÿ1êëä0_ “jÿÿ…;vºz_ý_ûÖûÿ¶–ˆ#ºJÖÖb9{SÚZh%ÓÒØøMáYöF?þÖ¯ šØ_ë .¬Râ:NY£¤‘?D޾ßá/%kj¿èSMjÖÒì?&ÂÚ.ܸz –(öÆ Ñ ò1^ �v¶‰(?úÕÕ×al D,øô*eXxÿë˜ÑcÁ§Çÿ8 _õ‹U2ðÿÅ)8i`ˆQ¥AÒÁä"í*n³³ £.͆}Òô!‚ÿ&ÂÉ/ÁùÙ*óX¶—çjAçkb�ÅïÐN‘!w M=ý+ó²ÐôÑ7}¥��޹È{rÁ»//7Úàˆ³oçc�8y0’zöÒ¤ÓO /Á»0C÷WØaEmkb"8 PµÕñTðƒ¤ù˜z�¾Õ6¯ø"bô«î8ÿ2 �eÁ®¿°‰²uJÚñKp—á«^+dM…Ó¶ý…ZµÁ¿ÉI I'Á{nû�vBH¼kÿ;?´’§2Vþÿ„’«2¬íû3 Ä’æHþÛ_­$¼ÊAëÊÿI'Î̃f·ÎÉûúH+Hš¤6_v‚úòä ðaT‰Èân¯ûMŠÉ0ÙÇVÒɱ*(eFµ°¨—ý´­-B DDe¢u 6=SüølP˜Mk65«#†É¢84XTµ¹ ëÐ'b:{¯ ‹ê#cæu¬ä—¶ƒíS mRÌŒ‚—�Aã±If@Ã-´J�ý.e¨7õᦖe@Ønôî‚ý޳+ ÿ^ÐAþ›K;2 éq­3²@Ïýý|™r/Šÿ¾T�þÞFyÿý¥ËB$ÁÝa£ØÍßž ÷ïÚþ@»q}[öò 7ºfòáâ"<„nªÚ¤îA!‹òmÖ­-¼&žY Á‚Im ÓË @NÇú'Ô^<² ;W¥MÓå¸Ì¢2+ ¾ZéjÞ ƒ ã* ´—}ý¦X G)'ëÖlæC‚íÚÅ “jv– ­¨Zø_S²Paâ+ß,xêv¦ �/áz,yØàÁH×ãõ¦Kƒü†õ$·5öT¿Ò]‰81a„’ÿI/sÀ½‘fA|¶õÖ¾C9¹ˆKÕi!�Á½@ÂIÿ+ä!¹pdd¡¥\™¹3)ZúE%ÂÁ×ýkä>Êiz –}%(NÈcbdæ¿Ú’P~ Ÿ"$6²l óX}…“b F88އ|› ¨.M€ƒŒè‚A$%&ÀÃÏ‚fJ¤S‘‘¨y€}4ÎÒ�2E´Ó;%ÉH.��pD;!:÷¦ÎÁCäIRt³¿ aò "®;à�N ƒÈ[—“‡äàýrÑ<�8¿ò8'Ú­ËÇ×\—ìJOÝHM§ÃJƒéÿ’Ø<THß\Í@Š�ÿ×äá…ߺ|/*Wëx-Ì1ûì5´‰ |íG�»+]{rbŠXr=^G°P¿ÚÚ ÿ6Ökxaa�ññÿ-ì?ÿÁùet°ãÌà�ÿ!…ÁA Óÿ+•‡„Óÿ ¼™p²•M´ßÊå¡ÌµôÓý`ˆY éÿò¸°Õö¸ _ý¿+�…ÿúY’ØtÿÛ_ ÿ±^|õËDÑ_íRh/ø�ÁùD§7ˆþ ×Â÷ÿ¬øæJ�?™Õs"ÀBö<Íy�¨xù�Ø'̌̒¾d ~d àˆ"åRÜW;æZ‹™Év5�]ÓÎÆ¢PK{_O§äPߢxü©ÿ_OäÀ'ÿô¯;P Á?úûê‡3ÿßÿ'ÿþ¯–9ç�?ÿ¯ã`ˆ}ÓÿÿùØuÿ_üùØhò0�ãœs9N#ý�Â.ä @¨“â:ýÈqÉw"ŽS�ÊîSŸŽåqK’ûÈ.åqÎ9ÜîPå3‰ùÚÖ̇®‹q¥ÿ]ÿõ�ûöè}¯b†Ô5h�ÿÿ¼yh�ÿÿ¼yhµ;2ˆ=gkA¦½v½ ¯¯ôê>ÑcËH~5Yf¤Í×Jº¦œ‡¥“rÔ²á¢ß k^¨'AýÒW…ÿ¢âê´K)nKÌÿÞ–ÚIdL2ÉÆKåf<oÕët«]Bké�ÿÂI{¬·¨S¡¢íí/ý$C8lª”l*µMéþ½ÒúªTú.ßïÒô�ýþ�ÿévJT/X]iÓ½R*ê*À¹6‡a„‡’ÿíéUÝûëÿu¼*UPþþ’ÿìEH1£»ô[¿T»JÖÒýú?él0§6ÂPÂÿô›ô‚ñJÇ „5"¡ÿþ‚Ã[ #xqÿô„Dd {{ÿIIÐ_~ÒõKaí(äböµ¶Mµ[rÿö•ÿµýk°‚ÿaŃvÒ¯Æ ^ýˆ_­¯Þ¯Ó¿˜ ¿RÌÔçbh×~MµGz£R ÒôÁ¯ÓMxªwúª–Ảný-uz ƒ×ê¡NÜ2Të·záUsºÁ„䯵ýs=f~Ÿ!ƒwõZ,|.b<˜øYo×ÂCÖ?�„p‰«¿�Kýþ‘}.´¿SºÁ�˳ä=†ɰůl {¸^—ò;¢.?îÃîErô_þC1`˜ò¶?Ø@ާ§ ü,ƒiZ(‰hkÿÐ Þ‹çÈg61ü]�e'É0$#¿ü Þ“ãçKÈ@Wò€$·ˆûrÍÿù% QY1¿¿ëÇÏySnR¨ r jo·kÿþ…˜Îà�Æì{cýéü–Îêr÷®õúˆˆ„Bkë»E (ïÉ¿£ £çj(°½´¼/ãö¾òa2øµ›X"fc;¬“ɤØW™T_Ö!…X _Ö›̨ËF3a•ø‚!d3í,#-A‹_‚�…k–A `§ Éæ+&þ“BHÁNSž×kè (ˆˆÄ0¿ ?,óaÿNè ÿ!Û©"OÿTÏþ<›u”µþX§ßõúÿýÉ¿¯ÿ•˜�ÿþ©ÿÿôHwÿoð¨ mxíþ´ïðˆhõ§]?öwüŠ>LxúZˆ¨Zè³bRoè%õô£×¥u}.’!ƒdºUIô¦,˜Òô¸\$‹7ú]]'² ŽaÊ/wAiDF•-/¥¥úÉ¿¤Ò]+o ÀJÞ¯®AÖ¥]¯ATG×4�b—Ð]Rõ&þ’“ÊÛé~Aö©ÒÚ¦úSa•ú\}+^”Cš@‘J>•È®UúQ†JÃÝ‹¥ $ÂS–Ä+ÒàÂEãÒá‚IúˆÓyn"5�*þƒKŽvž%à³E-ag`IR ”³)É)Y‚ÓA“AšÆ¾i¥!ƒ ƒæ†‹Š ‹“Úa*éé ÜÑEÞèÙEãJ±}]ié±ûÞ�,)do{þŸô¯´¨¸.4Ýþ•:ÿý:ZpÝuì}÷ÿÞ—Û®m‡¶¿ÿßT¿ïúk¿ÿú_ßýµÞµa…K»ÿè&þ?þ4½­¯ÖþÈ£û_doKÿÿ†«ÿnöÒõ÷¡öKÕ-¶×o×ÈisüSå%x¦+Òoµ_°Õ®©]ÚØÎq_i�¤Ú¥ .¶˜a#œ5b�qIDGjÃQVÅ5´—Ö a/—´¦pAéB§¥Tôª‰ÃÒÂI½* ŸKþ–·Òéz_ô¿å¹€`î°ÑëÌ–Á‹®¹Ú¡ça�£µØÞv7�[Ô þæFMÊ¡úÿôþd-á%ÿi$‰;æ#ÿ÷ýŒ, ßÿÿÿh$—ÿ’´Gˆá©ÿj©ÿ%� Q÷ÿ *ïâ?ÿã¿üÔçÕù„™{«�Õwÿ›uÿÿÿÿÿý’„D#hÍÆGÈàx*ÿõÊÊ/‘Ñ€< $ JãŽ""?Ã#ät�´r1ʲ‡0åPå¹Ü¨+ŠÜï�[±Ég$9·B˜öC‘ŽPävPç&Qrn² 4 Vv² ÔÑ7*[^ßì%Ø®× .#å¢×ÿÿ-¿ÿøóQ˜áa�ë�t7UµA úêš}Ú¢ò‹Ï­Ö›¦ú^ªêÿÛ W^MÉߤHzý–h@C�ÿ õOë ßË4m’$]÷ãÿÒÓw×þɹBJ¿zÿþ�ö"¿è�e¸¼D4´­ÚyoX8 a©µÿç@Ëé4ëJ_õ,rIû(r®‹¼¸i%qÿè|Eªmþ ÿÿ©ÿ Ü�+×_Ç%å->ÿ¥ÿíoïäFƒ*@—E?ì-ZZ\"l.’Ò¥¿a+m[_ô­{Kh*†“úJAÞQ±ÛJتüÉR$DCÂMþÔ1 ¿@ÐzOÖ´!‚P¿ÓM4�V"#aÿ..(¸zE?WñA=éô­mòL¯zÒn©µ› ¯HôA,ü*¿Ú^½µü› YlVÿMâÞ±ÿ$í?ò)°¶tlþ›WÿÿO|„F/ëýL†�‰ ñ¿ÿ¯õ«×_m[íLŠ&9nÙ0 ð'à sŒÈlÂpoü› &)öº[øa0¶ŽÍA�ùØ©Ë)ä„G,DE9ˆöÞ’â/ÿ÷ÿ–âÏÿ¥ÿý¿Kÿ_éuå ,;ðOÃT”Ž?R´}㨇²l�žK¤}Ú[Ë"° ƒ:ËDб�Új¤¯“XAÕd küCK ¹ %eº—]ù 5þ) ý ºäK˜L{ýn‘J9‚QÊ4û˜ßêשÙÅ�ѳ_Òÿ#˜ée-ÃD–ôÐkÿôTƒJ › ¬‡V6’RÑ"Á´G¾ô¿.ÚþBo¾·]„é$ù86xÃ#Þ m,[KäJß(Ä{\›úÒ¥�Í%دÐKÈcw�5çu¬%ò{Óà ¤–VÅ£°n#íõE`=s /ðÂH‚aS•@_;¬…ö+\:â×ä°?àÁˆ"†v eȲYJƒ¨Ò £Ë(°wà�äßÐ CÂæEÁ.‡àˆvý„OPüË@Kh ÞYS‚n>Yt¢¸"¹|rÈ&àœì !Ax"¸ ~P:|·8æ|T�F‰ß¡æ/5i¿�ÃrÚTŸä+p±ûɱ(ÉÈè ÈÛªŸ>˜Oà¦/ý4þ½kz/ØÈ‹ù0„?éÒt¾!oúö°·ïòÝA’Ç¡H/E¥—ïä0Üá„ z—$�4´Ó iEá¸ø·üØæÆ�•’†� ¿üÍÄ'§ÛJxAv÷ýÕ¤´©è Coë2%2ƒ# WÒõ+ é &}/IßHUV¹Ø�š Ö4ÓOTëKè «ÿ¦Nls[›)EÞ‚µÂ™-«ii¦‹zN“ÓiIãôµP‚¥iZè¼su ßïáZDÁ„ŽxAJ-Šbºzn±ÅzASþÅx ¾Ó]¿Ã —þ×A«†acŽë‚LR_¨ˆˆA{ú†I]+ßaé+¶IÖÔ ­¢ íN©ZGF‹ÇPÂV�AX~’¢á¤ôèƒØÎLP@¨†rkI$„ŸöÐ ¸é%¶—O(pƒD/¤­O-¨ˆˆAN¨ÂÒKÒÿ©¢Mi ¯¦Õ´‚ ati" bŽq‚ ÕXkµ´S[6ƒ ä%Ÿ…l,0‚ ¦…ë´""P•°±‚­ƒ‚ -á³³aKt“sP` Z{OÔ ºº'ÚËp c'é´YVå Bë×ýAwÕþdz·jüÉ(ß‚õB¿ÿí5èŽ<í@ùDpÛ«‚I!æGˆüEwû“0Ù÷Y+òÏòRr £˜r°¢~IBnC!?”âËÞ»ƒ�iþô@ñ/µñ •¾GvClrœÂ[êQ�d¹{ ˆŽCA¦£ê—_&9[#ûÐ_ÈkŽT9CœOcç�!¤tÿ›uüì%i'_þö©µûñí%ÿÇÉÜ‚üÂ]¥÷X®?Ö×�0¿ˆâ3¨c…ë“Uï!_——éÛýûoÿþþÇým¿Ý¥ÛŒíTòoùØš;GcyØ•w<¯ìKµNû´žv7¦½ÿÂDß§ÿüPA¿ÿÿMßÿüܽÿÑF·ÿÿðuÿü2µ¯ÿÿÍÿÿÿ�Á×ÿýNÕ„šÁ>þÉ"6ˆâÀÐ5¤¸Ÿ ã�&  â ¿ h c”9C”9ìÖTåqFņ°Od4‡&糆S0OˆˆŒœç�>+ª"HÖ¶ úv•�’5kdib¦€�H`Œ)¬`ò «#Π’€yðx"ÔQ’j AGÿå›Hì �ŠòÈY�„gbP aY_3´„v�U˜Mi„ÂÓTHw' jƒµD᪠ �>‰ÝÍ(A°´ôÝUÚN]V×ZïºÓ…ýÑcý]XU¹1á¬Vº0ñ ü›þ>·_ ø^’]-RqÒ;V:õ„¾½i.– /úVµ_K¿Hi].]zAëÖv4iwé6½pÙÞHî�?ÒЃ™K;ð�éé?âô¿ô¾¿éN9Çúé“{ÇRý-NÌ>vžÒúÒþW·z µé´¿¤½Öˆ1´íiH1²vÂûö_b¼5]Š]§Ã/iXa<ˆÄ!ÿÿÿÿòÊR áï,ïAý÷$>Ùð§¢wôÛ×è ïÿî·Öë¬{þÒù˜#ÿ _ôE�_DþëÒ…ßµ^+¥ïÒ×ÆÃ µ…¦B?²°ƒUÒ¬Ö£€€ endstream endobj 20 0 obj<>/Height 1309/Type/XObject>>stream ËLJãFˆÉBÝfÑ1ût½ºVWÕÈèò6ˆè¼c.ˆè¾^#¢è¼]‘Å#‘Ž ¥faº @Ìén—°é<†�ä8åŽ@�ÉD¡Ê�åaÊãœrc”9Nw(saÎ9C”9Ç(r‡(rœ¡ÈÇ8æsŽqÊr ã”åw)ʡʂœ¡Ï[”çr §(sŽS”9à¨*ÊãŽS”9PS•”pMÒ&ÂôÆÅnöé{t¼7KÛ¤W%üÉB$#±ÍºGkfK‘¡“å;(ŠA ï2<0¥;(�g7H  5»?ôûÂaÐI§<:é‡úϽǷJl¢ò®·h ÿª¿|'Û¤“tßuu ¿Ö­+Òonýý{WÿÿÍ>Ý$›¯Òº>%WëéL;ÁHpÝ/ù�Úxþ‹uíëíÒõé-é?ô·T¿Dáût¾›_»›«úOmðƒût½b’Û­ÿéZ]¿ý‡AzA¬ÃÞÇÿ]„‘³ßÛ¯¤) û ¿éc§ÞN?n‚ô´Xý»<ÿK¤gíç‚û×ÂIS{Òä5üA­7úä;[~•WÝ¢+øõ¾Þ‰^ý+¤—}�û_õ_c@·] ¶¨*ýªÞ¿2<—ýwXJÝô¿Þ¶ÿ{ Ø]+m„‘ 9εڰV %û¥®ì[¥aÆzC[­¶6+ÿ´·ÚÐPí~ÇÓ"»kþ˜ý‘^ÖÛ Ò§vOâ­†A‚†ˆÐhÈ–Ú±­úVý ? [ô­úVýl  Á¦@Ì5&¡†ºV×JܶgÒ†ëAX~·“a5¥cX«õ~?WÚŽ7�-«ÿü› "DE]Óð�MSª.òÆn´ÝSËG ©}7YŸŽ<ì³: CátoR;êƒMGÂ!¥UOÐ»ê‹æ‹çòPåãJ�7ï Ât¡WI¿ñÒ¥þ;O„¨›¿§ÿK ÿõ1éF›K²nT»ïKv«¯kiW Wå¹óDGÄGËæ©ì0”g4A¯ô-‹=Ši~ò¯Iá ÂuòùúºÌ!"pÄDG¤ÛùV°¿ ý7ó �†ÀU¤’~¿ö(·ªãÿ¯ayë1ÿýG‹K~ײl‘wÅÿUæÆ”œ?iZ^ø¿?m[^ý¿oÅEz™æa‘~—öšÕ× „ÿ¯@ .EëÚyêªøˆõŠÎA¹ÍouÝ"SõuZÒ~õ¿õa?ß¾+(˜¯¯^=>×µýɲ„<‰¯ðÖí[7þþõÄDEˆýk¢C´¼0º¶ü6¾×õÇKÿ[î—ý[ý'ÂdàÇÿÒøòna_=éxF³ßèZ�cáÚ¥i?ÕUÚH&Ô•¯ù6•f.kí¬‚Yø4¿�–f£:žž¾“{ªÇ&F˜A …ZßanÂÇ• }0Ÿ¬Ï],Ë%7ðƒTN»zo E�Rï¶P,".¨ ÚOȺñë‹}Š;‰êÂ×O®º]ÞÑØ5P@ÃUu¾›.]»VŽÔ¶tL}BßýxAØÓ;N�_úXÛ¦v€ÏØ^sý+âɽ9œ3· uýɵKñ¤ &AŸúÿæ:!¥$h3þ/ñ:×§’¯Ê°Î2²r;ë¥ÖF|>�Á±—â�l’Fý¿ÿu¬sÁžËâáõÿøaa„J+/HklmïÿÌoHˆˆ± Ó²ƒâíÿþ-Helµ–ûýmA¾ÔÓþÿ; Ê%þë\›Ñ&v 5p›õõoôÝ@©§°’í®–¨ÐhgÁr Ã?v:Øi0Â[� d  ÕvìS[Î4"r5„ü‰�á¨[L,î™9"_Ó ÿ•_øˆƒZ„ôÉNNÊ §Q1ܱÚ_�@ÇñmUB Ô*6‚›dG3ïTl®©§k_yÍÍY![R!·#.ˆÚ9‘Ù#¬.ê«5¹±Ì(Xö±õOMd4×ÏB"!ëZ¨T�'¨Xõª.T\>C5tsÚª0€ƒî»sDëa/…]&ÿÚøˆþ‹ï‘O1ná…ÿ¢l…£Çb+~:Z!&½ëê÷µü%ô²í®N j+Òzm$ýפ¢á$ÿúÞ’4«-ÐC�»ìÂT¿Þ ¨(pIé‘Cx�¤–¿ “bþì0§ˆ9Öâ®/;N ÿý­mâ!¢2>vY‘Пóºg\‡š‚‚ûÂýVð@Îꦡ�uTÿÕWBC8àøA„ U¿¨ªª4“‚h>˜D(íUߤ\,}Ã�a…ÿp¨±ê¸A`Áô@ƒ U'ã…£˜~e@„D „‹C¤M‚c«¥È’ îzëúô´´ÁÁ‡éÄ`µþ¾µäႆøéyqv½-.l,?ú^ŸéuŽ „Tí"Qu¡xú¦»‚ 0Ã÷ú\�‚x‡ò.‚D€€`ûa/^žÇÿ H¨½ÊétÝíe©ÐAƒ÷õuÉŽXà³®C¿PDM‹ÿ¡ð„l$FÕá ¯Ýòoÿ縨yvC`�Çÿÿöƒ &ýõñkaÿ#×µ‚?ôëë‚ 6 d0o÷úf€À"$ƒN Sý† zÂ?þÅb�f‡‚ qö±¡Á?8D/�Ê� ë’ü ÉÊïíAã „Ù”·øé‘™ �+"z„yÚG5`ÁëË®wÁ™ì µHUHRX‰ˆˆgpÎø4þB‹U¬*gHa“@Ø`ø>‹£ÌéU4è¥ÏãÂæµT]¹­åT6ÇK ª“¤åd"Á£ùþ–ÂôÞù Ÿ_Òï™èÃÇ×*¿Í�×øZ]6¹¬46WöAö«ëo-b²@gßÍ?­¿®“Y°ÙóT“dR"2�üCþµNCSyÿëý_¥¤‹Ç ѳ¿Öª—�$ÿ]*nAFÐ@‰%}ê©ÿ¥èCJ¹7Sÿª¯ì0§é/µûP¿üR~é>~à *¯á®³¤•ཨ¤Lz,z,~"">‚´‚ñ BëKý{? qP´ºÿÕ @¾#®¿Öá„/”––—ˆˆˆ@¾C O×^"�õ"#ét´¹74"õÓõ׆/ɹ�¥¥à‚ü,ÿºædP }ÛÿB < IÿÿÿàÁ}[ÿ�Ÿ:ä<Ö0@…ÿ»Zª¦¿ÿ#"�ꚢᑼé3X…,ÿÿýp´êª©‚¶×ÿð©*Nºø ­Ú_ÿÌ=4Xñªͺ, qúÿÖ‹ UP´wAÚØ—x�ëª$XõE�ð‚‡kKÁah±õ©�;N ‚ #úWãÖ‚ zÿ×Ð/Ä=ô¼[ð@¦Ã+ÿ×ù�ä\˜ÿ:_þA‘PAuó­ëÿ Ì, ¯û /Ζ†É�S Biÿ?±çKm RMÁ” ¡ÿíj”�]/ªiÃùùŠDy[ØAxˆˆûí@™Ù¢—´Õ; ³ºÀˆA7ˆˆˆ _I�qR‹ŸBb°@Ÿ„¦ ƒÁO¤ª©á~‚– Ñ;x CÂTª‚ à‚è-WðDMša,*Óà‚zZÌ?¼%Èe$ËzXÖ+ðpµ×z ¸�/Êå!29×Ö¹Ú€`í80(ˆú]i¦(ë„·ÁKä1´åìhµMä ë-ðDF‰ÞHDšÖÖ³²a€‚ü0ºiM±¨L#"¯ì0— ¿ ÆÁ‚^–¸ ¾…º_!—%? ,Œigaˆ/8åg*ÊsÁÇ)ÊV ªø\ì­ëðOùùÝ(~¾Ir8mòŒüD|Ì#A’Zò‚¯�S þC1ÊÝÿ FëÿÿÿÎÔ?øÿùÚpcºfIK��ZüÿÿÎË"2!�Êð³±¼ìo;ÎÆú¦yÚ€`í^¿kuTôÖÖÿ­KÏßÿÕRo;uëü/O½ÿýŒ=ÿÿZýÿÿøZW_þÿÇ®ÿý/ú]?ÿõÿõõMzUö]GTGGò:#¢ùÙD|�‘â;#¢;#Äp%þ¯ä €ÝF•}uþC!TsÁ‡0åŽPç¡Ì9ð¡ÎЗ¦G äÜ©x½W÷ÿÿ‘�ëþ¿«ÿ¶“þ1ö×à "2ÑŸÿûÇËFÿïdñ ɸR¨A­Sê‹·ôƒõï­?˜zï_±¥ï¯éu“r¥_ÎÜU¥ù† ‰õú ú_á>¿Ò~ ï™Céþ›ß^BûЯÐAáNÅÖ“uízɰÅû®�rö§l.¿­ŠèµÿaÇ_ûÛèl?„C<€¿ì›¯ë}øÿÿå8¿´¹¸Øgß}ý¨ÿºÖv7ÞÚÄAa"l]SOcZ' ‡µÐOMír¶Ò}®tëý®^Ÿkã­á‚zKøŽ\éoéÛ _íÂ_“y¯·þ¿ïäÙ/üìUýÿÛÿíïóÿ^ÿ·ë½Ú;'×ãzOˆk[®-úäÞki6–¶)ŠûU¼� A¬a«aV�=iÕRÐ"?×ýUtLzü-#þ‹­ð´�÷×^ž�öÔj¾ásñÒþùVõZÇ®ÂZ_Ž–ÅiêŒõKc´»]-®»]­ã¢Ç®—ëÚéiép×ì¾.ÿX%®‹‡¥±ë¢íë±ÛI Ûd´Bý-zÐO]²1ýi>•²1öצƒô»Õ=½a…Zé¾!�†ý4ý,ƒzëñÿþ¬Wè¿h¼úïÿ´H×ÿ4Dt]�õ†¿§I¿ˆ6ò¿:÷çK¬E«á…~·¿þÖ¿i}¯ÚPÁ6*êþ‰ì4¯=1^Á…óÓb”>¿�%KÏQUíyíˆ_°­PûþÚþÕmíˆ` Â…ÿ稢o¨n"—ÿ†©W»´Â­øˆŒ©åD•rßÉ'$È• $—ÚiØ0’_¦œ0fb¥ó7Ô¼hÙ†!%O· _Õ×6ŠÓK_ÇÉì-=~–DÙb¿¼È&ʾ¼0Ñ9¥Ú§'Øö2"�ö¶F=¹Naa…å½@Á’¨/ ÄÇÌ�A„Îê-õÒ$zÈ€½÷�� Á,È(! -¥a$ê»�Á5ØÎLWÿ4àˆêLr‡ ­ªÿ‚!äU˜¸B!‚a}õT#ÄEär þU Ã>¥Ú‘Ï<–!�ƒ–��E (r C–9 ¥Uƒîä ×)ÈgÞ³ºÀ�» ’*Ë·.ØD Áó@~›§2( ¯ê .-‚_ÜÔù�5÷ò )Øžu?̉ƒœ/ùP5?Ì‹†=­¯§™tHèÉ8=ˆˆÈÀê‰ÃímLƒà‚ Ðo´­##ƒÔ $½ŒäÆe��Ÿ §ÚÚ21AöPHx`„0FF¡Œ-_&Þ ä¶ùn`"|ÿÙÔ�×åúÿ<wŠK¿ò:¢á…š0ƒþAÛÖA£aáŸ÷!•ºôÓþ¤6lˆ/o¾féyvŸü·Þ“Oë–õ@éýü·8j~þ²ßƒ€G®ír¹ hÿÓ~WZ öv­ì%•Õ?ÿجÉ("`ÇÿÚÔ¤ íÄ0»"8ÿÇΠBûú4 ïˆüÀhrm|ƒC@ÉCœr‡* ¨<…r Ú%RI,£q<æJ€cæAA›ó"Àr8ó"€{ù� 'ó 0zdL™ó"àã2¨\"¹J;GcyØ–v7PyØÔKA Fv7*v½wä ûÿÂA¿ÿI¿#@ÿÿéóµÁÿÿ¿5ÿ_Éÿÿ÷ó0O_ÿù°ÿò #¯þ½ËÝUÕJš.ˆèŽ‹£ÌÚ.ŽEÐDG)Ì9 ·-ÿÐdtGÈàJˆˆÿ_d2AqÌ9Ç&ç§8ærÇ;œr ªÊ‚µ(r°¡ÊÚC‰^v´ à÷ëÿÆÿºí¨í"nX¬}…Ã\üyhåÿÿÇËG/ÿþv”!NƃZô_µÓjMËUÖŒ?Ž¿)Þ—ÁLu_Xj¿[T±¢âéWKm%È�>·I.ÿ¤—“dµý(ƒ˜A æÂ_ézÿKàÿé}ûÕ"¡÷ßI÷àð¿ØØŠDÓȨÚÿ Ã_ï ×¶M‹¨ˆûò¿å/ßµÿØ_ý¥ïÛ ~6Ð_Û bö¿&¯ûúå½Y9‘…¿­Pi͆_ú¦Ÿÿ2 ÉÌŒ5FÊ/;ˆbúêƒ5Û§“£h�(OèUl-uqTýUm3DkzËÇé->Øë­R µ×‚WÈ~(›(HÏëõ�„L}gaæƒ)ÈuµÓµ­ú¦ƒÁ&+:¶:Âÿ…ªk«îÈÇáW¥Ö¨¼h»}§»YRÉȧ*&åÄ�…µëZz|êÑwì|&ž¶ÅpX_I÷¦óþHT¨4þè=¬ycÅñÝ/ZMBÍÔnl"HzÈ;&×1w¾Úú¤ßÿ0ôNñú<ÿÿ $sa„—é¾ú7 ŸÒ‹Õ-v;Šž#�„¦å›ù["²vööü0°ÐõûÄuëÒ„ü0‘ÎHDGU·õ¿éo±VÅj¸vûý*½ªkI+±__„¼DGI/”�³ÿÐWé%Ií¯éiXI(�Ú_ÓkT”2C‘¬Øaqѳø¬$”�Ž´>Åmh$='Ø[ô×I}&ÄC…“y¡x6L8^#ÿ¯ÿ馭kâ":ºùDØ_ìWŬa…–qp"9h°#�‹ît2o4¼)ïëçÿÚè�—ý|/¯l˜DtG28kïÎÕƒ�à±°¯ò³Çöw0ÈýB&`xl#äÀjÿôü…‚�Èg��¨oõDñôJƒLà1F€`…­þŸÈiy¬2‚ El?Õ&òo5šÃW²  pˆhð¿öx5o#A•ýy1õû Ê¥¢R?ÂÇôCTÏEL qáÈf£$�µÇK¹ íïz¢Ü0ÊõŽ[—:È; OÒµæÃ/ Ê@Æ”�Â&Æi?®‚˜ÞuúZ]¯{º]"mÊ:Òíþº Òô­èƒqJßédgéoôDro<%EìÓ¥®’ý¥ü ¤ ?IJ ·é}‡Š]B ÆÔéNW ®úZ›Í¬/JQb—"¹&´£at†;ë[‚› °È¸ v!"nò¹Ò\H ùÚ|—ÎçwæS™Û™NIZ#d“x ¦A„ÐiDL&všiªZ}\VÍmŽlh¼h*Ž‚tai´ž�.�¾ÜÏ_z÷ì ¦ Æ\u×õk}Ó¥¤úü}ÿëÕ*ÅûÿZïýéjGo^þÿµýPTLrC¨MÈ`ÓÚÿö¾Ã –ƒAºØÿö?Œ%­öÿý‘�ðÉKíüÛ"¬›ý_ /ÇK¿ÿ�ýã_I}ÿ¼£­þ‰Ý-/w×Õ¯ik}®¨/«ûk®f˜jÚØIµm$·Õ¯ÍŠÓŠŠ91QG(ÂV¯[]xi­ÚÚJìl0»XhDC ¦B$½1Y78všÐQaiDp—K¥" JfÐz ©á*§¥J^t°’oJ—ék}Òð—ý/ú_ó$ `î°`î°oÒóµGÂú�©‹ÿ�„GbHìK;÷éÿÒiÚÛI$ÿÿüaQ<~¿ÿh% ûÿûT­ùðÈ Rèÿáªþ"?øÂ§ÿøÿ ²RC>æ@¡Ër‡(r îPçòœ§(r‡)Ìÿÿòn¤wX0wXgÿ­ûÿÿýoð™ž}ò>GÈùÑvGF#äplý”ù„GEÁr8ÃWñþ¾È C•sqÊ‘2÷Q Éôv´ c†þ7ÿµý´¶¶*Ñ7-P¸ÿÿ¨òÑËÿõZ;ÿù¬Ì|,3½sQ�K­¨A êº¦.!½n]½n'IëëONMÊým…[[ÿÉ�§ßÿ úÿ¬/¾ýô?ÿ}u×÷¥ÿ�ˆÿò4×þ�¯ýa…ÿÈÇDØÉG}ù‹�Ì6ÿõü�ÿòB^êÿö×_ö»Ó×û v¶¼ŠÍÒÐ[ $þØKccû¶ í`�‚òlYØB?ßû͆_ÿ�Ë6QÿÿÿÿäSbÛ‰ƒÁ¯úÿ. ì˜|úXo_õ·þ?ÎÅœ²ŸÛÖ¿í×Èf³¿I|›íê¿ûê¿ðØj”…ýãÐݤ¯ò¹¬KÐÓ\Ÿ;#¡Ì�„ âISÈa�lê ¦™UPŠŽ8ùd@MjXôMÚ¦¤3¬ríú¬Äú®NHÓK™�!µ­StÜÕu“v‹‡ÿɼô•uÿ ª‚ ÓÕkýUKßô‹«ZMÎR�?ô[àˆüCÿZ×ß{ë_‘Ü-.÷ù<ÏF_ê¯ø†:\»kKKÿ”?_O[„߱ɻ×^×[[i|¼}P¿¼ ú]w¶½X¬Eô¿Ù!âßZ[qëõýGô“K߆ú{ÿ¡ pÉ=’ÿ%¿åÅG�A|›Ï;Eý¥i6¤.÷þõÈJÂPÖÂM¥�™ŽYE×í.˜Ø£ÜU¯úM¥‘0à½�?l&°ÓŸ½†§; Qr-í~Iˆµÿ±òý…ø†5á­…¢Z äÜH7Â�Â"ð~Ñ=l @Ã÷>MçÑ á_ãüíTÿ�˜<³”�ÓË ¨0v®Uº¢íêwXùu'þŽÔ":#þ©¿óºÁˆêýÿ8Kÿÿêÿúæ/ü”‚×r`!ÿ!’ Påâ°ÿ�[ƒêŸçb"D2º ¦ƒ5”y’É÷ä| a˜L&ˆgÝdÝDÒiþÓTÎÍr¡VC‰všvòh|[ûEÝÚ.ä@ˆµ `ƒ›³u˜/�Ö _ùæß ÚOM¦ši¦�7þý¿Í½·\ÙEÝ(¼Í™vúݬ÷ÿ„t›I´ž›I´�ê) ïÈÇ(rÌýz˜i}}×þ“‚ ¿ÄY –ÿÂ`�øÐŽ�¤;A @†šë~ºQk¤¾bÌ4–ÂN{)Â-+OéIÛ¿#�#�, xAª.Ø6!¤ÚÚZTÙÒ‹‹X¸´©Ü ¤…PÂL0–•8u“·'n¤ï'”’m°@°ÝŠcÂ_iStØJ›¦Â ð�Wi…¥úTôéSÖ—à‚ö aiyG¥þ—î—”X@»b:M÷A-ý/úmt�tA}©Ò´µA:¾“î©‘Ñ#¨iM¨@¬?�K{b’¿Ò¾øˆ¶)8 AQ äúºµV•¤•¥i+Xh \}…´ˆ%ŒæÇ –3sƒ( A|DGkkkhD _à aa„á„)Þ‹&å‚ʦ¸ °ÂØ@¥;  ¨P¦& ø¸@¡l1‚ ¶X@²ÞÙeld€ù75I·Aß„ T鯂 ÷'šÎÕƒiÁƒºÀˆ‚¥º ¹e;¾ýëþ ý_Õ»_Zý/T?þTÁ—vµ—¯\ƒÁ7¤±úˆÖù°€[TŸ!’ê{IIó�}èC$ oLJÓ܆}êC>ê ¢î¿�4—[ü‘¦—6Õÿê‚ÿÇéwüàe¤tºú´—[Gj_=U­ˆòsAœÈéºøj"ì/õb¾;UÄ0[Èg@c¯\›Ñk\ÖkÿÛúN÷ûzÿwÿÞßãÿÃm.Üy7þîv¦.[‹,ìM‰gcyØ•zAçcyØÜ�§kÄ0—_ÿã/ÿÿI¿ÿþr¯ÿÿÈä=ÿÿü…Ù–ÿÿ¿!�­ÿëšÿÿ÷È`ôÿÿüÖ ÿý©2Fó^G‚ ƒ�ƒ’%Âg‘ô]ÌŽ 1*Ëä €`¸/ÈÀ�rC”9C”9c˜s9C…öC Ç)Î9ð¬)ÏPåS)¡ÔRÒ@nóàÿ‡Ú_Ȳ5Ö ×v–BHÕ­�M™ ƒ ûZR aJpAƒr¬«"Í@’@$øbj‚É5çj �ÿåšFvgb¼›ÍŠçeÆv7“ ÖWèì˜ÎÉ„T ÓZ„jD‡h“µé¢NÖNÚ �áú¢yAÕØZm-kMÓ®ëO¶µ§§ ¶ëE�¯ö‰§“8õæx¨ðºá>’Ý~¡~:ªUKIGõPJºX*ÿÒIt´«ým}výÒ”í+¯kþ�ƒuT³±'_¨J×Öw0��ØP‘ݤè†} �¯ú_ú_ä3îíè/÷KïÂ#¬Rýv’øçií/]/;0ðDt´–Ýu}Jýµë®•öév×�_c Wl,ƒ'†Ób¿»í|5á®g8à�‚GdÑ-A¸ˆ�ÿÿÿÿ–P°c{Ë;á¾ßrEó0§;ö›¥ÝÐ mÿïiw¯ú�ÿ Ú_4 ÿª">Òú'ÿô‚ßëñ]-~ö±Ø_ �ð™¬&¸ˆú­)hÖ£À@ endstream endobj 21 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageB]/ExtGState<>>>/Type/Page>> endobj 24 0 obj<>/Height 1304/Type/XObject>>stream •ÆÎµ,Ì*Ýû¤³8p“ï¥Øt™0Ì �˜ŽXåS•e9CÛ„®@Ì4ùÒöéa72ê¥9F ¬)Î9Qn“䨭Òöé{t½º Û¥íÒ;4"0SC4ŠvQb~d$‰íæé ÓOôçdƒ#i”ì¢ Ón’i£E+Óý0ƒM/=ºH¼ËÇWÞ‹÷ú&;D‡hÐûÑ({t©´�t½'ý„´¯Aö$ºýo§þžŸá:·KÇú˜wŸ'_^ŸÒ½[vém亮„ñþ›ù‡yá)„­ÒÿÿïÿÅ}/ÓQvá/Xi%·¢óÿý¯·¯·KÒb«~ŸÿÒm$·æç[t½&”ÛïÿÖ+ïßVõé '·…ÿôƒ #·�íïÒTaÞùà¿þ�Ò{x/½¾’¤ƒ}ë�×þ’ÌïóÁ·¨IoDqáÿéRO·«d5­¿I/ØÑµÿÂKÞÞˆãÃÐVÛÒÿëzÿJª«�}p•»ZK÷Ö×öô–ï}n´¡» ÑGþVKûT«­ý°®•†Åv“inű_±G$AÏÿ°VIR¶Òü{²+Ú®éµÝ�ŠÒ¶")ƒ†ƒ à ð׬VìŠ;k+dزÄFš ¡Á2öf­øˆˆ¥ ê•¿AX{¥oP•³Rô­š˜f²`ã’²‡*µ ¬�˜iÑX~‚·1°ÙMÅŠ§(s¹Cœr‡0ç§„­ù6’·úVÿ Xý(~!_«Œ+Ô{ Z-ÿÿãÊâbejŸ;-ά§¾¡êšiõDá¢pþ¨ Ü'¾¾­¯ ]>4H~ë¢(ï ׿Âﮜ›Qõõ¿°Á-ÿìBúß­ü"Nü�ƒÿá¤ÿKÿ±ûzÌý×þý[ÿ×äÚµýýßkÅäØ[4DtGfˆ�‘ÑîÚZ_ñÂAøaXk®tûÅw¬Á˜Avøa5úô“q ÂÔ´Í320×Zâ<‹£Ó „ç�{ý×´ë‘:G?éaf ØæÆ:q_¶MƒKÖ­ònäÇÿý#éo_:mzW ¼W|[?øòOû°Dïö køa/û[ÿüÝ·\õ—²GñŲ‡ÚZª_Ý‚#ýí«kýÁ„»sŠÿ�´Ö×&ü³Ö^Ê/ ÂÃS²ÜÔÍOöÒ×HDDdÌÔaý« [YZTÐ~dŠ¥±QG8¨Aª$íwçeIN¹= ÖÔ"&¨&ÐAüíÒ Ö5MSÂaa…�A­>ߪ¦ših»b"4l*O^*¨¸h¸a$ÖŸ6‰¾µ}V�Úª¥q^=áz}æ|Ã¥Þ0¾¼ìèÔŠ"ö¥�QÚái\Ãþ:˜é¦wÁhÏQÇKKÿ„÷ÕS\uÒõÒõñª¢á¯Ö %Ö»k+!Ÿ‘ÛýV…ô»]-.<>ƒüƒ­uuô°m-zØ"?¾›þg¯h±ã®KˆhC .Ëâã×ü-ÿ âÝ-qS!¼žH6ßúͺW¬~í-òG•0a`�Öÿÿ×ù•2vfÔüÂÂYÖ$KI½=¿~ÿK_Pƒ°ƒÎ’u ö× *z_ýz[ú§¦J²r'¬~Ú¥ùî(­´òvÿïÿ]}f¶C‘wPƒM?†8‘U¯iî‚{ýé×âøT�*me½ôLwìpàýö�½½Rím/ïÑcý*ÓAÐA´?L*ÄDEëb—l$Úÿù*ÍuÍeXøáé±M~ÕlSçKKTÔ ÇI$¦t:M,%;8îP¶šý¿TMÚ¢oÁpJãŠd,¾" Á ø£Þ°�aúK%‘Ê‹•‘ˆŽ‡ø�í.�Wáéá(‡óxCÇúvŸE�i¬ë$IÝÉ>F;DÄ¿ `ßZ¢Çã··ƒpƒpAä6Ç9'þ:×EËÿz鲺�eBÿü^/Òí½¿+–`×_ô»Ï~SýuÖW°ÖC(Û2á´´O}Ÿ]þW àƒßàÚ]?a.Ò¥ú¼®`u×ïÚ}ŽŠ&+´›VÒ+„ÿ÷µípÂØJ™ h1OÏ®¾ƒ´[Ærb².‡útQZˆˆŽÓTÑ% dH ö×u2B!3°‘ùIa.Ca @¹*!cÏLmÈ0a8_ØOL"ÜÕ¦j‚ä"3­ˆˆŠi“‚ã ÕA�„Í‚ð@µTšhƒZô j¨œ}9 Åô…UÞvÓ;84B"=}½ò¦ °@°ª—„e8 ÐV‰�E�ßAÈ™Áu×øM=�/DT—W¦M”�QðxQ×ýI±`4Õ‡ú_öd«—3ŽŒ†ÃYàÁòÁuÿ¡ î  ’sÀ»PÅÖ¿ëÙ-û é û@m4J»@†Ò×ä3$X2Pƒp? ?÷ù ) ´È7aˆ!‡z§èž½HmHÅ2 µÁÛâÚA�!”°^Â4È`\0¸; âú5€ƒóÀ£uþ·!Á èƒW¶C]l� ÖÅr�Ú«Dl2²d²è°«¿´JÃ+%�� -´°Â*hŽØDiÀôGEx°ÊýµÃ™RepuøÈࣿÅgjf xgsºÀ�ûXA�Ø3Ó]¶°×�†�y R íNÐ2le¬?> øaA‘$Q}¨aé™)`þàÁíT2 ™Œ`áqºðTOfx-p@¾Á~“|à�0È,H†/à™ Óü‚På9NPå$ª$=?ÄDEê‚Ñ|ÿ¢ËtßÿÂÖ“Wüo-ᮟõ�õl¾ˆ¾P�%ì›ç�_ÿ¥ÿ¾AÍ’¼%÷ô¿úOË7Ì©åG¥øì.—]ƒ i}C#˜ZV¶MùX­/Ö M¥ðdeAŽk\}Š¿í}ª /ˆ�|Þ‰¿ÿÿýúù7õ;,Žƒ:µ „ôÓÎÆ£±¨ìmgcj¶‰Ûý5Lìj;ÎÆúÂxOÿý­Uµÿþûÿý|·ÓÓÿþþ¿ÿÿÿ þÿÿøë¯ÿÿÿÿÿ×ýýÿûÿþC$6Ç8ä‡*ʬ(Kúÿþ@”ã”9à±É9NV9VQ'ÿ²À ÇוôFüÄG"è¾Gdp6Ï}è›”epDyÈè».ˆè�—ÈùÆGÁ³ÿ–�a¿ÿõµ÷ôMÊ~ÚM¯ím~Å1_i®Â &¸ˆ÷�-ÿÿñòÑÿÿ¨ó²ÈŒ‰“rÅU ÝU>«/Ÿ]/…]ú¯}z,C…×ñ×mz\0—­Š+`Ü›ú_õÓ"@�þ–‰óNÿ]7ßÓM.`oñÿß"‡ÿ†ùNúÿî¿þÿɵÛ }b½µëÄC Šã×ëøø~ýùI6¯ûßÿÿÿÿÿ¨ýge™�_¥)B&˜Añ“jÔ§�ÕÕÁ¦®‰¿®ŒíUë¦:à ©7×D½ ƒkÿááDǪU�§KE�Çép´¿ã×Fü”ZøOÚú\^Mù_ê´E·ÞÒí.rl•°`¾½=äØ]‘=D2†ú_úi„ † ¿ˆ7y�úª�ëúýUlˆÿè*ÓÔzïË(&uÌÈŒ2Z�H�‘ t�/e;×UL&šas=xü©ŒŽ0_oÕSMU4ákªT#ý,›òUšÚ/ª.è»c¥üÀi~Ã^ªONiº~µK²�VÅzõÖ‹×úZ_½…óÅxëu£ô´’ËСʳÄD0¼t´¾–“ik¥èDC’þ¸$øë„£â_àÿ¯µÒÕ­RKá�›2Ö—×­4÷AqÁã¥�–Ch¼tu’åh'®ìŒ~–¿J¤ÈOˆxa|C´›½L*™Õƒ;¦uͧ2Þ×ãZÿúü©=S „àæ,£]ÌÕÁõI§çKïΕӤ""‹³_ú]zeAN�¸ä6‚":Ά‚Ò@Èýÿoþ âfáÚJ×…WÈ3ŽT ëoûÿÖÂúM…�<#ÿþ¿ù³p¯�K? ‹ûÿÿ×Ó × ) ÿò1šÞMŤŽÈ ¿ßÿø…;N;ÿøJC7dwÿÿ„GAw ûŸ Ž#ÿ,”Α#5„A‚wÿóµ ã]T$® i¯i­ ؾW@ÁðíPˆêªe€š " ˆŽáuÂC?��µU ‚; °„ÏF�%dÀ'Âc®:"‚ÈØ?+A�=/†2*æ-tÎÆ|›°‚2 õÓ]/„ Œ‰A?/f�Îê4¼[ d r„h%v$ÎÁž¿ Šî‹ ä3w~Ey‚ á/DYØ2 ÿ„2ú_ x HL y:.Y×ÂEq€‰Â ½�#Š� ÓÅ…ÚAWV”˜}Ž‹�à„t›ÿjEq /) mO•”GÍkóóEq`ÑIHœF2�6ŽÓ�ågd�ö‚< ’Ô'¼†x z"ELŽ ""ÐaJX/Oi¢£#†@m„ •)}ØY €0‚éaSI¼ö1ØEÀAT µ]ôèí8!›µ ž“af_½"à‡Ù`UD2’97®Ã* ¨7pdbÉ­¢ ˜ KðÁÁÂ5ìz×vƒˆ ÁKñi„ ƒí8O×KhìÈ ¾––FV‚ýk íÁ£±´JA •$R-t²Þ "Éhp—10ºZ_@È! /öý)›˜ÙT  KB %��BLÂãdL Òò–jÂ_ Vè/;5BÁ‚ÈÆ–Y‚ùVþ²ÉP# ˆúX1 üƒrÈ  ~—&ü�ÿ�¨<*¯øˆÿû×ý¯ŠOïòÈ,_&ü‡ù64þŸëãÿñ�•ÄdCÓ õÓÎÀã±¼ìo;ÎÄ•V^?U´ÎÀ㱸ìk…T›ÿÿºõ¯ÿ ’»õÿù1è±ßÿÿøZUW÷ÿñêïúÿþ—_ÿÿ×ÿÿÿ¥_÷ÿþ¯äÀÜr‡8äÇ/ ¡ÊöWU_úUòÃÖþ>’ù\I™„GD|ÞGÈùtGDtaÑtGDtG2>Gˆù �¿ˆ;ɹB&Á7‘òù#æ">³Ò28¿ü›‹ÿ×ÈÆÿêÔ×Û°ÚñDÜ­°Â°ìµ†¸ˆÿÿ´Ü!ÿþ<´Bõ™²A?>©­)vúiÇÖwʪçc…¢Çø éuaM”/úkKôý~ŸK]>¿¢ßKò?¯Õ&Þ»ýcBåŒMÿú�Aûú&ÅŠ ¿^µ;zÿ]¿üžÔ–•W­†¶¾¸¯þ­ø† Ç�ví÷Y6,V¬"$“f±ëýë�kûþÚOØa!Üs°ÏM{Ú&À×í¥�¥ÄgA…ÁDµÐiØ0]v‰»¡ðƒ ƒüè ¤ÞÞ0¾—Òkߤ=~\éw“~ôî¿õ¶Á%ïµ¶—×_‡÷ßÎÄËä0l·ß‡ÿþßï¶×ùlÒÖ¯Õ^+»Gdîü›öd§#3 y>´¡»A«õÿU<8�OùÙxÐf²]2K”21¯vÖÒÇL Â�mB Ôë#cØI°–¨˜ïUUM0½=Š� ‚‹Æ‹J¨»ríª[Íà�µ¦ë…¤‹�&æzCÂv ah±û^=V©=cë dIˆäÙk'ÂèT¹ŸŽú_È&©¨ê\˜`—¥�˜¿Ò ¦Æ;T\5ôØ­%úé--Â"Xt©:ñwé|^¾–·–� Mü¾¢Ýéay8m®’Zí >aé ûh ÿøAãô«èo§Ñ‡õÓû¿¥þšÇÈãWý~Š·Öqé÷ø´½ÿÕ¯±]RÐÿ'¿ßòB¿H‘þ—þƒ¥ö•¥ë]ê—”r –¿M¥ì0°×¯ÛV×Õ/•`Gúö(öňñG8ª§ïH?ûÚÃXjÚÚ·ÿˆ`„0M0½2vN¾SÄÞ�»j‚ ¹#SûIö´í„Aû %Ø0’^šØÎ]Šý¶‹¿°¾Õú6“yn]21ˆÃ ÿéôó¨$+T©Öõ^,R¯¾¡J‡i!ë­ï—í4¿ª¤ˆº°`‡þgÏ2S"’ß ­#! #;¬ëøã¥�„“ä/$Ò_þv ØaRù 7ŸHÈ®ÎÆ�Xa$¿ÿß°eKÿ_øb]LÜG£¸?á„“ÿëÿ0�‚Kÿü?ÁŠWþ�2pˆëOAä]–­ÎÏ„ 0˜Aä>Ê׿~ƒ ¦iØ:µýpƒNÓNfDðÂ]oIÚ¦œ�±â")§§Í@› O;u’âˆazg 4&J²>GDt\aÇL…˜‘�9 €$Ô†|(r‡8å‚òf¨’"8D4H$€|ġȘW”9 ûªwX<Ì&Ë`DE¦·›ɲ˜f»MU²,“`PràÅ5¾ &Å »»M5—%96Úh0M0°y‘”C2À] Âv�…�²,®dj ´XaT2 "Žçn�p­® ƒÈR¤R*a{ðaëNFÃüê é�‘@\‹ƒÚ°B:ø7£Ó a…Їò gbq ]- ƒ!U»ªzúf°Á�@]Îëê$`EO­$ÉéŠó :¢vôº³€¿òpu„úZ¢ LŠGƒUõù ¶BPDeø‡R Ñ ²ÂßOêˆgd4‘ì)kÿY¶µüÈÊÂÇÿ _ßžð‘Ù>D_ú©2 \1Ϙ R%;à�W §ý•Ì‚µÓ¿ð@ƒ^Axÿ-»‚ .‰ØA¿è"œ0øOÿ‚! †>Ÿ+­Z¿Úà�5ÿü#)ÿöÒÊáAý¥„ ÿ±år ¿úk ÿ†d” ÿÔ/¯Ø"£¢<ÈÌ _£¨_¦NÖ˜@Œ‹xé— ô ¿ø/ÂúüÉP 2 ÞdT\ÈT<™TY�Ð/™%ðƒÌ‰‚ít󱬒í¤ó±µDïÙÁ#a¦v5�‰gc~›òT Ý­'ò, ÿÿ«Âd  ¯ÿÿ„ ?úõ}2œÿÿúd€_ÿÿéœ?×ÿÈioÿÿýÍØÿüDC#™´GÈè¿ÿþ@”cœrC”æ®)+ù`góµ€ÎUsÙƒ’IÙ'IIæO#åäg„ÓNiqLV”»i$– —Ž”&á7Q ,ª f2_—¢á¢nþÓZÐm-t’òT¿Ö× ¦¨ ôðŸ¶kHt’Jí-Bé¥.Ú\¸¢á¯Ói7ñ,(J¨„’omRÖn´nœ+ZøùÒ©h$’¶ä=†ßa$¾�é~“jIrs" JÃDÚœ ´’ˆzlBؤ­+H%ªm0ý÷Ë–@…}"w¤’¾ÖÒ¶­ª ˆcü,*i¥ñu c#Ý:I$刈È& 9E$OõÓŽ¨¼h»i|“¾#¬5Ò#;ö°ÒZGTbKõ§§_„ò bŽHƒ•ÚB! ^:_ D}-'Ké¸ê×È"'¦(EH <�A}â–¿!Y'çu¢è0„2‡+ýö4ô¯Çü» {øa,ȬpÂà ҥ÷ô þS Á‚Ye%wý¬ZMÿ:�‘h´¿ídíÖ•¥ aˆZO^Ç ´A,0§6Z¦]Zû#¾ÅlU[ b•¿-Å –(÷àÂÿ mQws³aßñ¯ÖÚÂxaoŸ—þè“¿LDG÷J— ƒú}„¡¯únbª ì¸ö3“þµðƒ;1l-«~¯ç`BÒ`ƒA…õý3³  -ãAˆŽô…}0A�Ø-§o]"8ôÓ+xi¦ž"–!é¦Kdøj�¤¯M2Ç@ÎF€ðÎ`ˢ莮JJý Î¡®GÚ!hŽ¢\ ܃ì2Ve¶\5…„vp<â�÷!�Õgc9 ¢Þ§)Iù �vj¸šŠ9¦šW/agÐ�ᕽ§ ™ÚIµAuGuqiÎr C”.ÁOé{VӔᤚiˆZGJ½§a4G $A­¤—Ú„Âh‚^ƒïM®Ó† ¢° ëá%ûM4Â&`ÊGDsrJsJA~ia„Ö #²$ôœV-fKA’㵃ƒ!� ®Pç­z cȱÎ9;!—³â/ÄA�#ud€\wk Bâ×ý¦T¶œ0²à×É¿ Á4:ßQaUÛð`µoãûÿÿýþûmq°â¿�ª¾íMýE„yØÞv$–2oÕ3±®ÎÆó±¸ìo;è ßz÷­Ëôÿßÿ@ÖúÿþÈM™§þ¿ÒÈ>Öÿ÷þÜ0ß_ë4_ûÿ© ¿ëþæ°¿ÿþò\zßúÿ�%ÎW•»Ía~"9 ÞhÑhEò:<ˆè�E̼Gd|¸9#™2‚ ›%奨n\ü´G'}®¨„‘«[ %A6¶9 # CÖd¸ï)ÂN€òpyàypzdmA´[PTÿÊñ�˜êÙ1Àã²ã;ÎÌØ;ªƒAá˜@ÁZ¢nÑ!ÚªI§ÕÖ^4Ñ;ÉÃ_·N&ÒAÐNµ­]k]éµ¢ÇïáU°µkúÅG“É�ðÖ´¿…ü,qÑc뤰¿…i$—K;05qõ¯]W]($½xa/ô©.—)ê¿i 륈m'ý#±¢K™…¬ïÂ6wa;˜Oé ëô ïÒÿÒm/Þú ít¸ƒŽ8¥¯é?ÎëzBÿ¥ò»½RúÒ;H××¥ºéyÚGÛJ–ý.¿jˆµvÒòéµû\w ÆÓ†ûKµ«ú 'à °×-"˜cÿÿÿÿË(°z Áº¬=å£Ã~û“—Á8ÉîÚm¯Ñ<ÿ龿NÚÿÿã½|_Ÿ¿á].’"Fÿ¢sÿëtºUÇ×_„­ZÅX_Lo„È‘¨†ñéxJ { <@ endstream endobj 25 0 obj<>/Height 1355/Type/XObject>>stream å¨ Êå}Öán�ÖaÝvè˜ü0é{t²È!Èèº#¢>mÈá’ íÒÎÃE:#æ‘Å. ÈN`nÝ)0R�º\†H5ŽaÎä åŽ{(r°«+jN“!� C�"9G*HÌld鈋íÒöè/nöé{t¼7KÌ•bˆíÅ'Øt’®CÉtCDhdÿ™xÈ�B)Ì¡„mÒ2˜È�B¡4Á~ƒNÒoOn’ &©^Ÿêš4{Ñ>{t–æ‡ú'Ïô^4_=´—A>Ý$^4_:t®Ò ÿM¤ÿÞ“{t©éÖûëÿ~ëJóG¾Ý-µý/'’oõÃ]û0ü4‡nK Þx&?Õ�é+z~Þ¼JaÞ�õûÿíÒýÿ~ÿýt’ÛÑxýº^•¤–Þ‹ïÿÓ«}=mÂ]¬WõN¿ú´“ø¿·KtšKnÇÿô‡0[n¾ôºHs·…ÿô’OmO…½uª¤Ÿthÿð—3ÿ è-í¥Ï}ìÿÒI&öõrÒ·¤‚Ion—:_ô‚ÿc—ÿÂPÃô—ø¹>ÚþÞ’_é-Ö•»Ò¯Ý½ª_ï[k¥mÕ%ýémºI/ÞÕ°–•»¤«÷µa¯ì0§¹G¯cŠÒ·aO):ÿ‹b¿ŠTÒmwÚÒ¶Å&»iní~þ=ÙØah+ ¯J=Ù,/ØOI4" ˆ„¡°ÂhD!òogl›�i[ô¬?Jß„7é[ô­ùJGD]dp[ Ä­™#ðd„ˆˆ�(lœ Á—JÃä2BŽIÊ¡Î9Ç8åqÍ9RzVÑ �Ó†&䬱Î9NPçþU•g9Fë4­ËfB ߥoІòl¤ªÇu~¯Â¿WÆ�G–€5¿ÿþ9Ø.uÔZ„Nši“sETO¼wZtœï‚u¦öï…]-z&ÿßõ¿Ýø]¥_QÿÔ{ %÷دÿëÓò6"ŽÉ±_Ñ<~©H7þßëù€ÿé¿Òþ¿ýÿï÷ûýicî�~þ·ûöÖÒÒü0“ /Ù6ûÅ{ü0˜ZüC.¯ˆñý?ÿë¦?ÿDMY6^µûýoõÿ­þ¿ˆŒì5 è>L‰0š• Æšyf‰"S Q;h�¼›“ɱ. Á„°Â¤Ú ¿TÓAÑ=ZÓïê‹v‰»Dß a…K§õH< Ü ÝÚ$?ioÂÕ¯øA¨]úµTØñ×þg�ü|Àÿ×ÒøNŸ,Áó®BN x%âæKC!™Ë!¬0@ {[•¤GäXÿ„A„L'ÛktC`Þoä1"ºi¦J²†H20!2ˆ‰ÃDáæ§.÷Óý¬ÖåÛEÛ º¤ðž{†F=÷íýIÐON©§ëO^ûl/³L¸õë4”ýýk5´]¹·”XñïH_™êÛÿ~‹xÒB8TžŸÌ‰A“„5-SýÒ$\­;þvh2qšÂB_×zñL Ô ÇV+.]ª}ôÿßýPa5 dq‚H±ãßJžž 5A7ÕÒt©¯÷½k,|·u…‹J¾¤sY³1ssôâö*3ÜtJÿ¥kªH<ÊžIÝŽb¢]¿~Ñ7rùí5maµ]¿õúü„ð­Z×ךœ ôûMPaRnÒK´›K˜úéü7NôåÞgŽ�û¤ßˆ0B#ö?a…ƒ p±ÅRÛïå;EÛ„…¥‘ÏÛúÇí%±L{Z\„þø·N9Øbÿÿû ¶šÇ _í{¤ÞE²qš k ZYÿûûƒh0ƒ ÒJóÿ©#]¿Õ0šz˶ºiüDGîÜûI¾ÿýQ1ܸhœ2‰ ÉwÊ:m-½µm/ø6Cbý­¥kŸÿ$z ƒ¤¦axƒ‹¥¶†”0¿ðÛûÆsb»KÓÂÕ×êƒM=½.)Š=±_#`£þöš¶»VÒm$XöºT\QwEÛ÷K 5†¿þï´ÖÖà Frޱ¡ýiº ¤þ©a!‚ê¾ͬ‘¤""?^ù 8Z'ŒîÑp"Ù;Lš\ƒPçrnQ[àÁ·¢.³lR�l‚܃í=¤NÙD^ÄxvüŽ¿þœ«ÃyûœìVA#@®im¬#ÿÓ«3Ãr:#£7 Ñ·ûe:#†ÑuiC A×wðƒV@ÜQ¢èC4� &AL¡«¹í-3²y¥–‘©‚¤5•C# “Q™Oþ™Y 970”�šLí‰qÿk¢~Éh+M°‚ˆ 4"VÑvLÃ.Bm: /»itÙH FmZ €Ñ7/Ù,Y{HR8fz±ZY ·A„VA¡'H9V tGtÂÿ»^È)5 #·‹«$"8) ¯öøDt]H4¥ÎÈ ƒP3ÙR†‘Ú€_È�Xæ"ŽqËÚÏ�_h�— Èi,¡3²àÆ„P�åíBÎÌ>CfìU­‡ýÚ@#�h/a"ŽPëžíC 7EìFƒDxaŽßÕÓ«`Áö–:Ýpd$ЬVÃJÂðaíll0— �6¶˜®pa˜Mw^“ap²åŸ Â; µïé ñÎÀ€Ž¦]ið@¼ìÀg-ÅAŒ`‚ý6¡…l©Ä1‚úŒ&C´Ðx�é¯�Ì1TO/ŸÑà‚¤I¿Ì ¯ÿ…Û§ã¢Cë[ü,kûÂ×cÿàô¾Éº¾ˆ0+_¯é}—¾—ÅñÒûú__Kæ7'•4RzZï†Kñà i  ´ŸáŠÒ´¬›“V—ë �cÚ_ØþëU× |Doþ‡òn¯×¿ú÷ÿO±ü³4Gbêvš™Ny7W�ŠÇbºiÔ0Açb¨ìZ;—¿ªiÒÿÕ¶‰ÛÿÿëOA»ÿÿªM¥ÿÿð»íýÿýW_×ÿÒ×_ÿÿÂÿÿþ×ÿ_ÿ|ûïõÎÔfð¿ÿþÓ hº#¢:.ˆñÌŽ Íÿ¿)Hº0ˆèŽdp%þ¤ €VÿÈ¡Èh¡ÎåP®*eHkÿ�[ã˜sŽBqÌ9C�Êr¸­˜9ºßý²ƒ�ÍTQÿ蛥ÿýÿê=÷ÿßí.»{jMÌ¿iZýŠb¾íwa0¸ƒ)‘&/-J·¯þñå iëãÎÁb"!‹íY UU>ª‰ãê´ýtŸ…^ú&=?ýiá~ê1ÒîŠÀélT­«&Å‹¯ßÒÂ#‘0Åý-Öÿôßý/åŒ"ÿi?Aÿ÷ïÿÿÿüˆ}ö×ÿÚúDØ¥}´½±\WöºïA…×ü?ßì|‹§á¿¿òl.¿ÿÿÿÿëýaZ‘%¦]šŸI�c¤9Ø,˜@úÕS”ñ)T'Ñ6+AuDß:#`¿§Öª°ƒpƒ5TOŸ…U®˜DY†iñå�\z"Û@ޤª—ð´XôaþZ ïØék„©:Lz,}þ•»ÂZZõ ºÓÖ0´¼Ù㮕·ñëÂÒ×!õâý--íäªÒï&ä×qÚK×%îCúÿí¯¯OYEÐ28gô¾ÿ:Ä7} ôºyfäßî•÷ˆ?ÿsÜïÿÕ6¢«ÿ^ÓA…wÿ-"áºäCn¿úþö×— B@®Òɹ4M–s®hD`ÿìWª¦õívªƒO�A…êš.ósÌ TÝ?ɢǭø?­1¡ûRY;¯&" ÑnZ Bæ¼E‡çX Âb˜ë¯+5ÓOÒ )J ª¦‰»ô»YÖU›0›,¦wX6—T›§&ÀY«4"ô¶ÒåPõWÖíP®ér°¹�L×ÒÎ�×M6´µT&ƒ±G)Œ2ø½­uÛõT]Ñw°–¼˜ívƒö¾›ø†þiºoKKUAáMÚiÞu’ ‘l—ˆËïõ_Kׇ…XOèž1éiªþ^ýõ},êõ_ôÒUèë{jÂæú[ó=<§þª¿ÚV�éa.È®jÌÅ!. Ûáuö’¿µMWö3›®­U5ÿ-XêûÒÿ{]iwꩯ˜ÿ^šÿ (IWö¶‰VuŒÅ5�¬õY»çGuéiÿ±H�í=üDDWM¥†ü.“kµkõ¬ØÖEÚȵ ®½U9c½Sî•}}°§¥¤“`œ‡Ú¨aB×_U›©ñù¢�ñÑcþ)?BKp¨ƒ ÒÒðª“uýøéz_†ú ÉXb\ÆËëK×úù‡0èßZéiV" �¥àˆ[a#0y ÒëæŠ0ñÇÄC öþµ\s¬—‚t&LŽˆæGP¤DSÚëÃ#‹ K×ì%a-.’ý&Ò  d0°"!×?zZ\Xë¤ {ÉŠ× Wò ‡à‚EX?¯úÒþ¿ö×ZIjÅDh˃Zÿ_ý-+ ! -4�ƒõÚB‘@r¦é8oýmS—"ZXH¨b>–"@@‰0ù( ~ïþ â×Iý,D 7% þ·ÿÿˆi^j’& @²ÿÿÿÚOÒX YUÿÿ‘Œ§?Ò#?ѳé +!�ÿþÖv`3çY+KûÁ"ÀAU »ÿÿ_J×úÁR²>ÿÿïèƒÙý‚B""Rà áÚÿþv(ÿ¶(·À #!ÁÑ>vãÿÿÿi0@��ÀéîÔGÿˆˆ�ËPÃw|Du+ÌVKÚPS ‚õ9ºÖ—äÝ/êŸþ ÿÿÿÿµÿ#iÿí¯ì%ö(›škˆƒÇÿøùhÿÿøùhÿ™s$ ÕôúH¾ôÒmëçtÇîw”Xô¬ é~dØ­Rý5þè>—Ú}/Ñëò6ˆá G×ô!¤¥úÓ}/ê±Ä”ÅÓÿÿÐΡ�õ&Æ\쥿ý{Kúíÿäö±´ºõ±ë“e‘“Œ§[_ ÓOì/uDÇh˜þ!¯^4xA¾;tôÚOþµ÷·âÝ ¿&ÆZY‰Mðˆh�­ÈÁ<µÒ‹ˆ{ÿY'rPõÚZPƒpƒÇoËp25e9%O_´°ƒT_¿l(¦š¥ýö*nz/_פ�kIöÖb67õÛAZÿ½¢lR‡T´uiL0—턺,uòb“côv(F¢ Öµµ°¢!v.’üA„#M‘1é/ãDá¢wÇT¿¤ƒ~•WȦÒéÂHAü†W½Š øKûË@A�2KŽ—Iª¤F;ª^Ý“ri5T»\»5ÒýQ¹ªÈ"'¶ÂëlÿÜ(Utâ¾á/úÑc×ö»·ã×4DD}÷ò7ÓÂÇ2?�”Ÿß�…þýÒÿÿòÚ /g,;Wý|ȶ¶ÚýizqV넼 îç`N¿&êô§ 4Úßéz$î!…ú^— @Üm&Ö³³@ÍAkÒnà 0ÂW¦Ñ<ÏþÅEz¢pà¿éæ°�¼,'˜“úóM0`ƒº«tdRÎÈ ÁqQcêçxu²6'^9{&A•Ö^A_k1¥.q È eh3Lám„MÉ«ˆv*Ašý/ŒáëÜ»h2.�¥­´Éå&Ñ(e 4±_ ïÐl]ˆ ÖµôúlЯÂý&A¬È/¸�ÿÈeok÷Ê.¤Ý0íu2P$–Óúûi6‘’p^òL3ûÎ(­�Ð c~Ú°Òe` in¯vª²¦mý_ÊÚ„JÃ2Ò·Ë™pÊ“)Ïd)A ¥a…ÚTîAé‘ Êb­…KÓ=†K†[V %·¢Näã“}2r!8A²@e†+ômÔ&©9ÀËjZôÝz¦´Èe™Ï´¶®ºuoY±ªÈ¾Á„ØU_ð©:ì…Ù±Iÿ]°«-q6¨tŸE¼yžd4¬*ûØ]B̉†"—ã¨æ@ÃEWýs*�sÍi¥™ °Ò•L“Òù 70s‘„2Õ,ËÁv=…_µMt³'Ú°a$¿T\?K&€A-*0A ¾[qJNºZd @…Ť¿Zmtº"`ÂpÂKôXÿ],ï Žˆ .Ô$žºéæ¥ähŒRµqý/KP d¶ª½uµù³‘A‚ »r¹ °¤Ý{éé’ŒjúõˆˆËùð^ l �IKI²à¼Ð1±O¾ºL‚íÌ΀û¯t„!M §„OëÓ$mä‚+ûKþDF@Br /¶–d¬f ÇÆrÌ„z‚ ò)íy– ¹Æ°@•à s#ƒ”ð&Y ‚ì0°D<•%�@0Å`²ÉP.Ö Ë%…#ûË&…ä,‰%zda•À€‹°z„‘hT A�Ä�)¦™N  æËG@buÕ&Ù<œ‘�ÎÊ3©i}6l�‚¦ƒ×Òd6‰PƒæwôÈ`Ü\—²qÒÒsºÈCrÃX" ƒz_�Ø0wàÄ™¸Y võý2–u3 *_Uò8�PmæÁp‰ßJû Ñ2ï¢ °U÷ª½4æ´\[K"mL.¾!Ú¤æÁ^×'²Pµûý�m '‚öW…õ!––.?âÕ¯ ›?_Ói›dÈÍÖ‚¿�ÄŒ™éŠÔfm?ÿÂðƒOþ°Â)a„©§ýˆ"Z C¿æn¬òpòܸ~‚i½ü/¿Ýe¾�ÈGëõÁï·å¿‡Ö¾–ßmp@¾¼VW2eZûí`ˆYè0²¹(ê#‚ÿÁ²àˆŒ®ZÇ‚ü®s Ã×ÁëL� ‚!Ú4óBÉ`£u­& ¯ÓþF¸ÿP__æFB?Ì–C äÝGÌ”Ãf[•#±|ìV¹�As"ÀÎy ŽÀ³±Y5ÖÎÅs±Ã=¥þõ+a¡ƒ_þ‹ÇåT41]ÿÒ~È(hkÿôß’€Ð ÿõ| ÈØh¥ÿýáU†ÿÿ¦S†�ïÿèŸIŸÿÿôÙàÑõZ}/I�Qº{;tGË¢>Gˆàfý2 ,•gÃ’�´¾8ˆˆ¯ò¡”9!ÉT9ˆ+Š\Sù €j”Ê‚¶”suŸdG;”9C–åYPT®få»yÙ›__ûÛKü0—é�¶¡„?ia„¬Qd5ís$‹�ÿñòÐ7ÿÿñòÐ7ÿüÉÈ—¸ 念D­®kI×¾MÍ?¢ÇðÖ–VA¿#!T´‚˜ºáð¶«ß[¤»è›ÛZ兩Ir(ØëzKNE#®ÂIu†þék-=ºúHAÖäØ_þ—ÿ}P_·ÿHטEÏÿzI¿ýõ¯ÿa$Ì×ïØŠˆ?ñµÿÃKÿ"!ãù6ä Êÿì/¯µÿÚÿì%év ÷¶—ãb½+ µµéZðRlSߊç‘Ãf×#ëçe(Öúö˜ }vE·(r‡(r¶YO‚æVh“¾CË: â5Iø_çPai¼›“áQ7ßô«×ë ºü›–á ƒ¶—éÁ²`Ø¯ÖØAïõôIéÈ`ßO¶ÂSž‰ãǾ‚ è'»ü ú·!Ç_Äzæi½}ònOÝÿa±__kõû´Lþ,/m/�Ã_†^J±XÊ#¬�okꓸa«ç/ònOÿúëíZü¢a¥ýŠþ×Ä0·Ž>t:dDkºçÿ&äúZäÅø_ý)hÔ_Ó=ÿê×þ²Nñ·ú ƒ}¿Õ þðµ|"}&éþLëâ:Çýp¿ãŽ¿�_cÒøý¿KúR ´¼ê�ä sa˜@�ô«®”¶�Ít²nMiÞRÖ0´ëJ¿¥oúûz @×ß×d0·\vïÒ蜭“rk ÿÿÿ S(¶ÿÚ ¾Ö~Õqœ ¿ãÚì(¾EòOãajà ø·`ÂA>l3¯á„‰Ûø0H&ü‚�ФüGò͈KMe¡#%ÙÙȧ:Ž[”D»;AäwL„aa4Âwðƒ0š aši¢nå»EÃ�?0<í["ïS�4í4ÓšÚ.Ü»pƒiIç@#< ÓM‹†‰ÛFÊ/(¸h»¤ôôëÓÓu‹ÓMíxMíÓtôÞé6—OWOYy­¢ñ¤ƒi7é{¤Ýi_íö¿áSr î‰ë­/Òoz¿¿ÿÿõ¢ìÙ§÷ý¿ÿûÿ_ÿÿ»ûtßWémôÿßÓÃKîÿ_ý]ü½ˆö¯ØK¶×õ[b½×Û_†½ßÿb—b—µû_¿Šøý�÷ÿµÿ¶Øýûû"�öF:ÿÿ§é¿²(þ� þÉ?Ã_†¿ïþ‹·è¼}27û_Ó~?�ãîûKô›ú{R�/CMÿÿI7’.Ûÿý;û~5ªëíÑ"]I¥¥½[Kÿúü‘þH¿ý[¦ûïýÅZÿÿÿ{_÷éXI°“k aÚb¶ÿ¾öÒ´­+ ÚÚLg8ØÎQQG¦*ô×¥úZPÂžØØÏlT4�lV­¦¶šØQ  ½´˜jà Å-R´Å+ ÂiÃ@Á0¢;{ŠŠ=1Ma„pÂkh·4 ö·kh´†ûXaA… ÞZCr| ø*}Sê‰;ð¨?ASKõ·×þ»–�c;ØÐ¾µ-Ôó±B0˜Aÿp@ ì D ?ùØ™�Šh0š$;D¡¢x‹„ 4IÚh mA÷XOL&‰e‰ûA:¶“}RMQ;rxá7MÓ{tôöK/‚mÚM¤é=gd"ø,~0I'Ò“úßd #ŒŽ ÌDWÚJ›~öÉb8ˆè¸5±QQÿk_§%¨ŽÈùs#†\DGÿ x9CøaBÝxˆˆÿ�+1Eì¾m—ñuä¦S•®m—rö#/b=öº½ùr¶W««¦ÖÒÿ¢ö]ËØ�k­…+Ž‹¢:.ˆèº1‘à ZýúV‘ÝäC´-aÉ ÿÔï\"‡hCDD0A¡WâЈ†ˆLrsqÊøPåaø¡�~@Ô Á‡+ŠCì�b†“ü‚ÚŠåpd]�’ØØB5Ȧs.Œ#½B�ŠYà7|DD0Cñþë­ý¥mqDÜÑZ¸apÊdìü|´ sYø[;u­ªiõ½4ü¸¶¨œ4NßKp¨ ÚOëm~›ëëMÖ:Ü*êÿäßýýatÝd”3ÂÿòlUÛñÿÿzZÿûÂ_ÿØ�ÿ#`ÿkÿ_µÿò)±ž -ÿ˜F£ýþ>ÿù¿ÿ’ú]y63[]÷_½…î¯ÿh/[KÈhŽý„¶V׈ûh.)ŠþØK &¿±TÐaa��¯¿ÛäVjÁ°Íòlgÿÿúþ?ÿÿñ‘q>t üƒC4I~—“bŸìh>þ\oÿ¤ïÿý½×geNYdº_öõþßÒXýRýúYsì8axƒû•äÜŸzÿ‡ $‰s²ÿØMÈ`ßMEï�:ºä‰~crï¿Òñœ Ìê—¾ý%ý…ÚY7'Éëÿ†ýlWƃ_Á|~u1…ÿDrRà²nOÑSÈ('ð@ÿ„C¸Ñ-Ûaý¸@Þ4C9pŸ¦#óµ§ó± p�Üp�I (Ñ'}R„ï.´ü3ŽPç«*{ó³GWÎf¿_þ¤rû,Š‘ ȃ+’™ðr_äÀb!ïDÜ<”`�„A’A“Œ„Š¡Q„±[ü3€à�¦š ÓÐa©ë[ûOM�™±ªjšj‹ÆC—,П~C™g!•!¢Ã,A5’á�ܸtôÚZ/š/¢ï.ÚÓ¤º„ߨAé„A ÒIKýºéÖ›§Zõâÿ íSM:´ªÇÿÛõIë :SÿËÞ¥Þbt]´]´]é­'í*ÇHf=ó?T¿ý$ÚJ“i=6:_±î–a¯ë é{Ý?”¬éu=:Zþ“KøA¥ìPé-výh}JÀ€ƒ7ñIµUí(´´šÖ’òR,÷ÿ#´XôÓ �I%úHœ>–NÝi'¥¥×ïô!¥Ë†‹·.ß—%T¡„Ò„ô¨:Z¢íé$½^´´®´zt›I %±I.úU®’Mépiåš5oÖ^4¿Þµ†šI27¥WéoÒ§Ò¤!êV´©×¦Ú÷J_Iv–T¿T½0—é/$[ÅRBécB¾–îÇK«ÒÕÐ_¥’o{O¥x"ž«ÚTÛiQh+õA>DI~–úÃL--ƒPKTŸÐKêÚ°ÒJý+]*ûb8Këô¿®Ò�Lr�L $ytÚ\‚{(¾Ý¤O$ÒÛ * ò‹D¥­m[žˆ=Š9i¥ûƒYÂò"HÕF–•ÿ{† kö½§°úJ× l�é6­„ºÃ·5G@ÂÈh'ѱG-&Á­|{c,†�º�ízX¥µ°¿µº£É é_â"*š§ˆˆÇ„ÝZRHŠODà q1á…íŠM«ðÂÚ‘ŒÚ`ʈˆÁPaŠË3Z¶,²š˜ uÁ„R¼›¨0@Ðg`BÑ7¶v$! 4„-´ Ñ'gf—á„·OËp±„J„0Âa&Ñ.zÝçáAºm:m'ÿO1dìVNžšDñôÓÿIµÁDí»^�a�â#ƒ C�†ÿÿ ÐzÈ,²ijÉhm1ÿý3°2I³¼ r†á�@ñÿÔ—Ì é²c#¢>GN6@ðn;DÉ�ãýê’‘ËI´ÖÍ�áž@œs4]2 |ìcíéqI°DXv€ò†Áè½—ÙU 9 Ħ¯ØŠ[÷@›$ Õ!¶9‡(§v§u¢;—± ki+ùÚr* Rz5´‡VI5´”Ÿ9 n¼�¸æTF1‡'± Ä+Ø Ã C h=ñ xnA†M:M1QHä ZQA„à  “ÉqÊ,_ ]Ê3i�„Å0¤ˆë%p„E´ŽÃFÇ/eÆ!h~‚ûHAé¡ .©VØ]0ÂàËHë{x0ŽÅ>’®Âl$?I¿ !vibÓÉ G5Ú_Å`Âïµ�0±ˆò]|êuɹ5]h/ÉÁ¯¾°Þº{ÿo¿ÿýãÿß]»\›“DÜ a¶½�‹£±|ìVNñ�¬�-ÕšýÚ<ìW;ÓOþÓIöŸ_ñ $OýÿÆŸÿÿÓÿüã_ÿÿÁïÿÿàÿÿÿÈ<‡WÿÿÁ�ÆÒÿÿÁƒÿÿ²‘DtG €ÚšÁ?ü…">GPbK‡üî´` a«*ÅùP3LrÇ+Ê”?È`å9C”ç¡Ê7 Âû!�aVS:È/ˆŒêü ø" ³MAò�‚×'$|;K!eÁ„°qÍ©Ð0 È;Q(—*Ň��$`$ê(ž P,ˆÕ" ;T`ÿùjÅ,ÀÑØØÎÆÆ²ËyÙ1¦a²ÝLÎÄ…L&©§Êú°ƒ=5D­¢xÖ©¦¨�µ„§^‰ÃDù… Ú¥¤ßTn�RÂíúÕ-&×p¾Ñcþß„H}\›Ç.¿õü-RK¢Ç� ^Kôµá~:�� —­R~©.¸IÖÒéa/ý+ýz^ºGbÆ—^Ò÷Òm.–v*Izé>/Font<>/ProcSet[/PDF/Text/ImageB]/ExtGState<>>>/Type/Page>> endobj 29 0 obj<>/Height 1304/Type/XObject>>stream Êãqfu u‡^°ë0n‚ðÝ/n”�˜4ÒÝ+Vé{t‰°½1±c¥íÂ^Ý/n—·KØtŠéh޽éD@Í Ò)âDA™ÞdC(ÊtGD4L ŸaÒA„Ó«Âó!äń [¤šhÐÖôIÝúª^žÝ‹Ì»u× @ÿóCïDñíÒ¦ÐOºßMþ´é^‚·_ßêõ×ÿ«Û¤—þ¾|uÿúW«íÐ[cýL;ÂôaÿÌ?>-ÝÕvôÖýK¼'íÐ^•Õ/5ú]¯·¦–Ý/V5ÛéÿÒâ’þnøn—¤ÒG=¼úÚöýýº^�áúÿ®HÛÛÇöëé$žÞ|%×¥Žš¾ ý¿KžûxWþ´‘�½ç‚úÛé$—ýä‡~„O·«d?A[Õ/ö9¿×úK{'žð”6Þ’_º[kÿÿ ]¥¥oT«ÿ[_̇’ýõuÒ· $—÷††•_¾¬4´¬63”ƒžß»þ¯_ ,.•¶½(÷‘µÿÚîÆÅi[ !fSBƒ?¤ÅnÈᆂ¶"4!ñ¦‰b¡±•¿Jߥaú ߥoÒ·á(lÐ Áª@Ì5f­úVé[™™Ô¿JÞM†Ö†Öô¬|Uú¿Wá_¨ˆùh�ÿþ£ÎÊâ¤1jƒL›–*¦�ÕÍÏ­>çx…^¯ëº½Ö[ÿÖð·Z»ö—ý�×°—¾ŸäØ'Ñ'o�0uü ߬Š;úA¿ëý0Õþ¿ýÿ{­.¾¿î?Ýz¾ßþÒÒÕ²l1vÂL5ë¾Å1_ý¦µoˆ0ƒ þ#¥þ/ýué“mWïȺë¥Þÿ×Jïï_±�–f¦j}0¤É¨ ˆÊÈ" ÓÉ¿¨@ÕŠ&ïáx5AÐAû„K@Â¥íý]ëü ÚÖ¯øAå¿øŒ-jú�˜/ÇÐAÿâ×å`äXdß–„ä0l”÷Óoý—„Ýõ¯ôƒ‡ýùfýž›¿þºu¿÷ý¿ÿ]÷Ýq¢ù¶«ÝÞëÛ[KÓ°Â¥ØI†¹7õö)-ŠŠïì*Ú Á‚a0¿â"?ÿÿ^È7ÿ^?ü†P¶—ß“^»ÕõõßùI}A|a~² ‘ÑðA*¨@ø@аnªžMýAª¢qîÕPMüâ«Mü X_ú„‰�E�WüZ_÷¬ŠƒÂ믣¥÷àõ×þ >X.µøcK_òoê´¿�Á²Sƒ ú¿ê~—ÿB“z‚ ùfüàÛ|_U“tŠ�q?ýalé�#Pàë÷úª§ÈÆëН4:,+WêR}~–V›˜ §ö×&þ¦z,zþÿŠî E�_߆¼qëß¶"ÂÿKüŒ1ûÒÿh‚ûSõ¯ðÁÿõü0ru�­ü Aâõ†YUrC‰ÿƒ¯¯�'àÁ�0L›úP¡WûJ 0½…U_ÏlÝzP¡B‘Lœ‰Ì§/î*^ÌüÃå�–>gªaƒÿj %�‘“‘àBŸ\. TÕ1‚Z„£Ž8Ú¢ï64nÁ}e¼ǯøZm&öá½R ˆ4¤¥"tGDtGDEþµï\ð\©#\SØZÒ ˜A¡2ºÚþ¦z½cÂÃL� ôXôŸE½$ôÉNN3€æ¸‹äã3H"¸ Ï‚çüþ�2'A ø_i0´Ñpæ\5OôýP~¿ýÞ–C)%Q'h›ñþ‡XOÐuE¼†Âª-Ú-%4[Èl+ÿþ«µT6‚ ÿ®[¤µ„¥ A館7ªÿûaRó÷ÛÿùŸëˆUõ ¥zJ—Kÿüit‚¤õÿ¥ÂëÈ瘠ˆý6’,|±ÖúHÛI?ÿ鑽,-}_ÿÇøº8Zõ …×F>]Bÿ?ÿƒ¥–ñÿþºû‹Ôqþ!¤?¨ïÿøª[…­_ú÷ós“‡úúéÿÿ×î¦, ­�ÿõÿ´ðƒÿ^ü»i~–""=úUD¯ûkÿ�ÿõëÓ}¯ý„›Uýýôÿ¯¾.•z^Ç{�M�ú_{ $¿ÿÿÿþÿì&µŽ’ò4Ç”yޝþ¿ÿúÄ@Áð—îUÿVºï¯ÞcÒïñ¯â!Û_m{¯þþú\®¶ tÍ"ÜSsŠõý´´ºm•,¨´º÷­­ƒ Q!|0“â®J‰ }…Öÿh5µÇ§ìqWìzyn;°ÒÐ_ˆˆŽ×^Ó_×õ`Ê¥ø†DD0A„" †!t눈¬0´®»”¡t@Žk¬~+-_Úõ½»2RˆŽZ&fA`_ÙØÒ;°Óê™Z’8?³°`Á, ߪdlá]Í´IpiùØÚ2J –óºÁ”™ŒŒ�§¦wx4&|SçjŽÉ d·Ó2Y#°<í@EhØ`—Á¢¾wPÝ•«•\¸2|ìÀ–§aŒ 5¬î°_õI¦v0 }�¤ D­ë;Ð->ˆkZÜ­�ᜅŠT€÷�f¡ÊdL2 È€<6h9Ù\tÐz xe�šØ4 ð˜O�A„2�„Y‡ x3ŽR¶vMga:¦ž™+ÃI2°‘Ó®¨�¹vðƒ;ÄGDpÓÎÄŠ;5­Ò;?ÚáRé¿OA×ð»«ô©§ÿ“Wÿÿ…ý^v5 ÚÎÁ¿ðµÿó°uÇÿúÿÿëûYØÝÿÿõ;v¾¿ÿ�&p/ÿÿïýñÿýþ¿WûÿêëÛkب¢nW÷zí0®!„\G×�–ˆ[Öþ¿�-¾ÿò¸€1Xe�/:£1¢NÊâ2!ŽÕ;¿„íUVª�ªÌ\ÇUDñäÚ´¿Â­<ˆC2ì*ÕUjè9ÚÄtˆx ùžŒ=xU_õTèuä&„%É�–=ýÂꉻ½.ï KÿIVnºåÓw…¥v—„×§½.ƒÂª×YcÕW,[úáŠÒ…¢Ç Dõÿ¥Öt´¾ø‡ý-2$ Ö–éúÑ;iÖ—]Ù’OÌyG]m ßZéq^t­+^—O, t–»ÚÚøƒ««¸†„0ɺ¯b�lW×Ûûý­¯ÿ#Óúâ!…A…ÊsÃyÒ!Ä?¡í]õiõ÷þ×íÿž˜¯Ã þר¯ÄDCd'ü5é þ>¿°_ÅgtιÓ5—¯UOЪªfTΨêŽ�ýôljšß¥UÝU�åTšULƒ¹7õ �">¸…UKØõÌ>Œ,~¿ô´ž.´aóK™%–’Øéii€_§ZêòñékëûëK§×KKåqÙV·§¿Z^LÜì³##¡øŽ„4!×¥×U\ ÿÿ%(듲 õÖ—�D"AÕSý¦¯U0ŸЃøA‚ U‡ÖuΛjº§ýtDK Uò¼/[IUmoÝz#º&aWþýÏLaVžŸ:D;èl �†ºOÿû V´¿ÿ< Ú&=>‡ºŸ��ç¿«p�ëKó²3®tΡ>ŒõÌK^±ZZê«ÐŽ– P u[ÿǯ..ª«zZňˆ�¿_O]fØó"ÌëšNZ÷/|‹Ú\^ª½jOK::a/®G™JªùÙÕ™™AVLv‹wÒ½?a¯¯MÜÏ@ˆüÃëL* 5Ð ÚA½6ÿ¢c].Ÿ…¥¥È‰UTÓUúÿþ•×#­å--=t]ѹ D}GKòõ_ÿˆ>æÚ5ü�ï ´ßÂÑŸþuÛW_ÿþ–—ÑcÕ¯Ç\%ßÚÚWÿÒÒÅî´Xñÿ¬$ßìQÉ�þõê«ô=i6–—êU�ki?‘Žÿˆ8‡Þ– 1V¼¡Ã†? * /õ¯ÿéIbŽŒ•…˜ "@7öÒúÊ?׆Ÿ¦Û#Všwרa|éëKë:HÜô!ã^½ýŠ÷í}-º1ë•ÍXO�°¿ÏlUq[Î�Ê?s±Fp(ˆ0¿ö¿ÿjÖÒó°ÀÇÉâ" ÂöqÊÿöH↾w0iüJ@��QéçaŒ‰†rTø?ú“ž¸ëöK†æKÆv)¨3ü‹|ìk;85¯f€G[ìš½é—9ð#Ó* ´¼�}‘ìƒíRv"`ÖGD0ͽÏ´ûÍ?d¸iŒ‚öAÛÿA�„Î�&ȤDe=åŽ y˜!�Ð1yÙpÏßõ\ìÀ…ÃU0d1%lï@#;¬}-Wä5–gPr¨ g| Øa™ÿU]ÍÛ¢ ÎÔGsÌî€æoU^@�ˆ, ƒ–s· …Ã3;ÀEý¤«è‚lœŠW•°Øˆ/1¾�Ž °¡uü+YUùð|¥ƒ¯Ø¤Lz,z,~K<‚†ÄÊYøµ KKú*@žEÁ¾u eT�;† ´ºþʨ>¤l6d@c!`Žv ˆõ¯ÕÙP È)‘â`%€úÍHÑë¥þL�õ)Ãc‘`|”ü�…¥×ùÛ‡NÉÃFJÁò&�HÍ>´»A©€ØGYÁE],ýë¯!‰#º¦ˆeìò¦Ê@þ—ô´¿;Ð*€W•€ÆAƒù¬Ùë®°bÊ"8ò”LÖµÛ_Ñ îC8—v\LìÔ1d€Bfißÿû;VŒ¤Îð0¦`ëîÿÿ©™”·Á�^Ù€wÿÿ¿È&Ä<ì0ÓÿädSÞ¾vœ2­ÿÿý§�ƒ ÿßÿís´áƒ±ðÛ ¿ÿW„ÖÜSÿý©Ú‡wwB?úwdc¥»XˆødGGX�Å‚;„uˆÿÿÎÕƒý?çjÁ|Éf˜ ²`?i�Â~¿\É(úcÈ1¢öiøJ±è/á'ú þ‚oá&EšQZ”/è$2)(á%UAý$åõÉ¿®@…B¢ý÷ÐT¾ßð–kë¤Ú&==_¿!–¯ZX¯ý‡ ¯èÉlè‚ât¿øfŒrC”×K"#õ®1ÒÒ¾ºR6J(ÜXÆ@­-.þHDŸÖ—þ]ÏE1¿÷à z_Œ0`‚ô¿†!z_à #]C;•…AT)ÁIc;*}DÿÉ¿ÿþ"Ê |Gýüü›ÿÿÿÿÿ©Ù\FD2Çá��£±,ìo;GcyØÚ;ÎÆúªzz¦švµYvýþR¿ÿªÓÿü.¿ÿÿ“‹¿ÿÿ…¥×ÿÿáiÿÿǯ¿ÿÿ¥¯ÿÿõþÿS½BˣȧFh¡ç‘N“5#4yFˆò<�¥!¢:1›FˆÂ(EÑ¢5 GÒþ@˜Àºÿëûô­è›”þ ÿÿÿúå9Úßiñý×Û_Å}¢nYß ."?ÿQòÑ·ÿÔ|´BÜìÓ:>uÓºË‡Õ ÝU';ö?Îàµ`ƒ¢Çú^é“`j—éÝu´ú_¢kô=Òü�‚Bn«úi?¯ªìh†{óOÿ_ÿC$¾M‹:��;ÿ®õõ“ò‡+b»]zG`Â]_â¿Ó†¾¸ƒ¶6ÇÿÛòlX°þ膉+Ù¬_î—ûøúý´¿ k²:ÅLFÃF×ö‰°Eý«Â#¦ŽÌ԰טAá‚è4ñè�¹wú Òoä0cz~«V·�~¾�ûúKòoEšÍ•ÿ®ÙØ«}éÞ¿ýÝÿ_åCù63wñ ýûöþ«ß½LÍ †ÚÿÛŠÿ»�„¿É½¦¾×â+Iëãö½Øa&Â_b¢¾jÐk©úÃ_NÄq®@ƒô¦Æ}®<›Ñið‰†ûÖØAëðƒÕáþŸë×üþ;R¬ïÃö•äÞ‹ì¼'»i$²XGRëkMàƒ:ål6dœèF%Kƒáo®»I.ú&éµ^ú t’Ș%¾¶Ò­99XúîKà„uzKË/ ÿADô¯Û&Õ«~—úýR*»ïJ¿ÖÞ/ﱈ1§÷µþþ·ÿƒ _Æ"?ÿ“òtÔ›T¶ëÚ_®Â_öÒõí„uØ…êæK:);_Š„B§Ø^’ë ³(Û≰„¸Y€ËéB¤¿®gó?��GBë…È•á(Aõ� rJŠ.â©ðOÞš ê‰ÛÙ͆üÝÕ4ëO�‹z£[EÞ©>?ªOMÈ`À^ÿÂö— ‰ÿùž5�…þMýg¯…ôo ˜[i¥ŽÁ˃D�…ýv×ÂQzÃ`ƒØ¯âŽ_ ‰*Ít«¸Aí~×çV ¨OÕ¶"Ó�sd«Aªk}ÖLwÿ@�‡¢vïîµA%ïè Þ‚o}ü-6•þy6sÒÞ‹_¿éá@,é�Ö°±ÒÛk­ê•í«i]‡kþMý*kÅØõK±[רUÚ¶µï’`£ýBªá…L-$¢Âû]ÑcÑcÔDGK�¶¿\.aúUdì™.KÇ/IdùÖ„bµô½/é7†þ¹Ýú ºø†Pácõ®’͆RX�Ò]ëÿû]>A,óé¿&þ¾!¦G_ö­ò¶ˆÍ—ÿwb¿È;Ó_ø5Âÿ?áÊ^¡ÿðD4—GõÑXRh¤0cD2ð†`Y6°ŒÍvYV¨�‹\ýàˆ{Dº#†_“þMý‡¢$…Xð¿ó!PöJC/¯þ…ªTÃ6ÿåc:™; 3°5Ô ü#²°Ò_ú§æ@Ã�¬¹'ÿTNß™VdàÉÛýPOà�H-<ái¼Aò¡¬‚¡=Ð3ëùeÔ:‘ U¿~‰�_BʦKAKÄp±òoèÈÔ*el5#×ùÙ0`Ö;8lã¥é‚�ŒüÐ+Iô¼ìheÇë~|=ô¤0l•ÌY€ËÒô ¯”€úT0K×JfAbÜ¿®—1EíédßÒý/½izßAz{ÿ[z ÀNÈ9'ôëþ¢8¢còö—Hia-dßÒ þ–ý)>uŸÒß ª ¾ÂúS—úWý+CˆK]Iì ´E‘H²oé(à élô¬Hìq< ¦,2%„Ÿ¥Ã“ô¸0H¾ú :!¦ü%_´ú\p‚®”è åÇ•ÄiBéç`ÆkÝŠ4« Ði¦•)½]ÑqEÃ&†j,¸4*nCš Ótƒ òH2œ’Ö§ëô®­=0ƒ UÞ›Õÿ{©®AÈ·¢cÒÕ·ólfô¿T›Jƒh Ú ÿþÇìUi$ôéÿÚ­öþö‚ ÿÿ§éú^�¥¿zýoѲ¿ùrKmö¿ÂI¿J¸´¬; Úþ¯ÿö^*ÒúÿßÒùBž*:Ek4"œ“M¢Z ¢Çé*iÍ”_aø@ô²rÕí:z´žØDQÊpúê´ƒs\}ÇáÐ<›ÓKµZÒmk[ho×:T´õ­ØKpƒýmªG»ÜÔ%D3ˆCèCú¯ï¾øþúVºàÛ çjOó¤—þbƒ|í@8@üìe~¿ûl“ò-Ç ãÚZUÿŽà��â^•0oË¿±œëOÿ]5_.¤ß´¼C}è‚Y{(–kÿJŸØ_ÿ¶–•é6«o&ôÄDjêÖVS›`—ªÍ†W¿™úûÅlPêµÿí´›I„ÖÒS˜£¯ê3”` ­å-/”�ˆ‡ÿµ´"’Z\Vçc2P±ƒ*A´µú‚p†<›K¥ÑkDûò æÞ=2¤DäS˜·Z_§øµ«M4ôE88zþæÆHhÙM4øâÿúO[h»s[EÛ*¢™Šj‘F[ÂþÿͰí¥]:OXM4í<ž%íÿŠëÓMËŠ'\5Òû뤷Æ¡á7Nd 0Âç¾È9i�¿ëÆ›U]'¦É,Cйb¿¯ë¤¾¬PH|W ΀–}ëtþ—ëKæ× ÓÁ”9f !`B#E­VÒÒKé4ü=åÅl—Ÿ0Òmp—á$^2!¤…ú ºÈgØdÚƒlȢب­*Õ*mÖJ?OV’!¬¶î®ÓZKé%ºPƒ~8é °9Åçua„Z[é~–ÿøDL¡Âûˆéw¥å—ê’I ]9t{¢ ì+Ua$}¨Iÿü)¢>aè.¢Ò‰Š[Kᤒ@ˆŽ‰(‰Ù ÿÚ�K¹ŠKVô’ÁS¼EÀðZ¨â"*ÖÒM®’IQ, �ŒÁhì?îÂv‘°ÂG6P¡% €…aC”ä1Ê2ÃÅ ’Á)�ˆ;�µ†IP H4A„ÖÊžTXˆŠI(@•2 SØKJ°@Ÿ#@Øh HÍ’Ñr Ï8 KD 'R1Eà¿ðA5” ×…¶!Ð C�ðö ,DD"º¢; Q1í‘¢$¤C•á7An!ºaõ¶û ªï'oÎÆõ × ƒrÊi¦v‚éë;V ÖX Kÿ×OPA{ÿÿ;¨CœsŽaÕõÎÀ…)`Qaé.]ù@dv­¼/ù €W.Bl ‚ ÄR§¢†5!¢Æv  ÒW¢ [5DMÀðDÁ´”Ÿ;�MˆEl  Á+O!�èóºÑ ÊRðƒQ�zˆ,è�iuØA“Ž”£T6Ô%² Ÿ ~4wÁ•Mküì@$Øe„ÖúûUÖ:}mqíV–ƒ”h�ëö+ãµñ ,›Î�$8΀¿ ×ÖMéåÁ¯ô°ßëÿ»ÿ»ÿÿoñÿá¶½¸¯çae“zpív7�‰gcz��çcqØÞv7D0“õ¾õã.ÞŸÿôƒõÿüëïÿü¿_ÿä.Ò¿ÿÙÚ¿ÿþ †6©ÿÿù ÿÿù¨ÿÿ¾Dÿµ$#ùŒò.ˆäGF2:#²:.G@k•òÀ.Lø/²¡±Ë¡Ê¡ÌçƒaÊã”9‡=•ÅqXQ9\VºÙÐËKPÜœàˆ&ÉCíkTDÙ•pOáÚX6ÖÚШ2²U!ƒ†1‘ öä@I¨H™ƒÍƒÐ,�¨5ÿå¸Üv4gbYØC;ŽÉŠv�gbNWA¦xA ×a0žƒTÓê‰Ñ(aQ;¬¾h¾kJ76¨&¤é:ÓKI×p´ý¯ß°©Z÷\ÃèÃë®L¢CüuëCŽ‚÷…�Itµ¨_°´–½ZJ=cà’],_½BK×T¿Ò´º]×úW^¹PÂÿ¤v&Òë‹i„�y‘PT³¿çvŽèëJí|0O|%ÿ¥¡âz ïÒ~Ö8¤>ºìÅñÎÓÚ_éjvLåqßIoõtþÖ»KK_Þ»kÈ1±�¥öÂR lž+V+Ó»_ý¯kà ì"܈�ÿÿÿÿ,¢Àø=åûÑ û}þh!ø�öÐwü'×Ñ>ºþžÿ÷ÿÝÒø÷üÿ™‚i|-ÿ‰~ºRsºý·õö+¥þÂV¾)† Ö™ ?§yh¼R�éBÂZÔp endstream endobj 30 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageB]/ExtGState<>>>/Type/Page>> endobj 33 0 obj<>/Height 742/Type/XObject>>stream Σ¨Ícª 'Âa:¢Vä¡Öh&áRzzí¥ÂþÞMÿø[i+á~×I~ÅwÃ_Óò¶ 3ˆ¤xº8‹¢ ìº5�r8ÈèÞGÈèÚ.ŠP£4B>]FHŽ2>_6ˆèâ.�a2CgDáù`2ô7ÿJý~ýKÔ¡ÊÙ©LÀž“ˆ�ý×ÿßÿÿý×ÿum/öºÿm&_ب¯í5÷ Âøˆÿÿÿÿÿÿÿÿÿÿÿÿÿÿþ½ÿÿÿ;3Œ”GXÕoà�š�s¹'`�‚3@ÿOÔ&M«õõNMÚ$퉻ÿ/)Î=ù}A<'@�´n¾“eC:µJé´›ïæ72úÒIw^ºzêÕ$­~ÿ_“(Ò!‚ø®‹*mŸoŽ=ÿïºI*ûJú]h¹ýÕrãô´Ÿm ´ÚQýˆº#²:Ði$¹ m¤ÅJÅ_ï‹ô¾Ò­'“·÷ä²’UÃcAÚA4›ïkMúY¬ÚEã:ºDñ‹ÿ£¨/OUîÑN"NØJo÷[íUwïmÒ^úÝuõwôö•?Ýú¾¿LKþº�J¹‡§æ*KÌUø§üˆ}"címR¾þïkUëMÿÖ®½wKöÒI¶Òm%5":m+Kõ )ëøi%pÁ(`”‚ø-Šb¾ìW®ÅnÅ+ݯá…îᤛ &Ó …ú,ÁWÿ¯ëäÌ|ì*%/®¦� >¿§�]‡ð¤!¤úÕ?¤“T¿òoÿð´·ü-køõÿÒ[ÿþvJ2 dáþ¿¦ëäÙI1Ú$ïúý ƒp�Ï_Ó¤õÿ©=©o¿é?GqS×ÿü™È2€c»¥ÿkÅkþG?ÿÁÿÛX‡ô¿„3$ìUÿ´¼}©;ßëÂp›ÿ /ôO¿Òcò 'Óoý¯)Á�IïÓ† ÿÿˆ�ïU×ñÿ1ío¿ÿN®¿ÛSÕ¥il%°Â±_â¶)¯á­„Âøˆˆÿÿÿÿþÿÿú–P ÏÝÿü°ÿþ¿ßÿý¿ÿúÿÿÿÿï_ÿßãÿÿ‘‡ó /ðˆ7�¯‚á‡á—AÐA¿ÂøCñÿÿÿ’¿Ðgt�C5,Ú—µ0ž ûTÐx^/'�Qù~ùeU¬/ü ¿ ÈâÕáÔx¿ÁÑ=�Ó_#á£×#·ø@¿ðƒaÿiþAvU¥£ü[üTýÿð‚ÿ~ü¶P _ßþ‚ üÝaýÙ°ä…þ^Fø_\óá£ý¥ø@¿ò1ÿ¶–_ñÒü_. ߰°ÂX@¾‡ûÅaÿöŸ(ÿ˜È¦á„ÂP@¿öD\ ¿ðÂJL¡×ðÁ„°‚þÁ‚  ød>, ¿†!aü0°‚þ ü-,Ì^8AGð‚þ*øAË&¡ _ ñùdýü ¿„ð¿ÂþA#ø_(ø_>/§‚ý›Kÿú×ûÿÿ…Š÷ÿþ_þ¿ÿ÷ï¥_úõ×ÿÿé~FÂd4E ¼GF,“ |¹0Ðy)È”ƒI2<™Ð6òè�¢Háæã²ù5ÈäGFÑ›EÑ2K¥òÀeÕ¤ÿÒöPäEŠr‡(r�d‹å9à¥q aÈal£2ÜæÅšW–’¨o ¿¥ý.ºZô›úZ^Az5è0—د†¢!‚�ÿÿÿæJ™-ÎÂd ŽÕä¤ÎÕä;�hèv2 ó¨ÎÁÄfé’òvK°�¦KÁ¤ªƒMS;[ªªªz„ÕuõTתª®‰; ¨�µUUUTO¯UÕP@ÚªAµUU“Ú¾“j¤®*Ó¯VºªÒ­8UXUUUl*îp¾RªUP�^µTµU º®ÒõDŸ0ôH|›Ñcýz&–—K­-'Koõÿô¿ÿé~–––úZ^—étÞ–—LNï†GÔ%ÈAß d}D6nª!°g�ÙD6â Úâ ÒЃø‹ÿ×ê×ëéÿÿ÷ÕÒW6ÿüÛö›ªdAÈÝw"ò Òr ÿ%Ùò]þK½lCCú­ÐJÕ¯ÿi}õÿþšÞ¿÷ýÒÿ]ê�šwÃ_þKá­éo­ã¥b¿ö+تýöíᯠÿÕ-…ïì*¦5,€ˆ²–†ãÿÿÿÿÿÿÿÿ–BX­¢’œÆGEјÃ#9d.)²Rª*„A¸žïߥôßý-+¼¹¼¬µ“«*ÏŸÿXˆ�mûȵ®µ~ûë­ÿ’Èvkfo kÿ&;ÁõsŒ jfÂa’b—½>´ëA ðž–ÿ}‡Üˆ;X�Cûûz? ò<"ãÑ>ÿû鿦úar9?ÿ}\àgéê·÷KþÞ=Õk×¥ûþõý¿ÿÿû൵¼™{¯}ÛÉÁÈn¿õþ¿íáûßþÿöˆH÷ÿÿÿöôNŸÿÿ×þÆ—þßÿ×ÿ¯ýÛÿûëö“ÿëéúÿÿô¿ï…ÒÿÛ_þì^$þ² 80¼†zÅñþïõ÷d,yc…¨dAõ¯|0œDD0¼~>68×ÿ_ï×öõßý`ÎêoKÿ÷–é¦Å)j“ à endstream endobj 34 0 obj<>/Font<>/ProcSet[/PDF/Text/ImageB]/ExtGState<>>>/Type/Page>> endobj 37 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>>/Type/Page>> endobj 40 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>>/Type/Page>> endobj 44 0 obj<> endobj 45 0 obj<>stream H‰œT TSgþïKÁ… „ $q�ê˜q²�¼¤×Ø© ÐV+¨€¨¸"¤Š­G=*n3U+ " …© 8Ô€(EÇj±­ŠŽZ"L�iµjëèÿž/Ôùÿ÷ÐãéÔž9sNò–»|÷»ß}ÿ¤dhþ�âš™>7Å•‘–2'.ã·ãç¥S³‘÷GüVà·1ü‡ ¾—’ßÞ=h®8ýÉa7ûäi�å:ÿvYÏ’�¡ÝÐR‚„|‘Ò `¤GaȈ̈CÃÑ(ƒâЛhJAÓÑ\”�rÐR´­E›Ð”�v£2´U¡jäFÇÑ)ô9jFWÐuäA·Ñô#âQ0à jÐB0è! Œ`†ÁHˆ�ñ�a2¤ÃlÈ„wá=X«!6ÃV(„Ýðì…*¨�Z8§¡ šá Ü€[ðO¸�‡†aº0þL Ó‡ e0ƒ™¡Œ�y•‰bÆ0±Ló6“Ĥ0Ó™ÙL“Ã,eV2ë˜M̦€)f>bö2÷˜§ µÂý–Ùl2sÑN‹ÝMM\t¹Y,Äâ0‹5ÂIcè�ÄP‹É!Å8ÑNHœ6“„㈠1–h«Õj³I‘"9iÌóRÖh›ÉÊIqva²K fê’ÊØ¢ß²Z9‡5š3™¤’äÑi!˜ä�2³Û)=K´ÌÂlæÌUÎI®f åe¢u8޼ÛÍRÍä�šlR%©¨T‰‹–y›Í$…†X “YêÄ!ÁÙd³Ez‰ NÅ–årÊ�ÓÈÎLÚ…ÍA/fI&'¥f·š¨�rçlÔ'q—U– iœä–¹PŽÊBó‰Ÿ&qV‰,­n£I&«T\ Špòxh}&Ø2I‰ˆ4Aªƒ“„”á�8š%¨´ò…¼Ûd�lRMR‰ÌÑ*Å I€Cú4he•Ê&t~RGN ÁÑ©a§ÄAþ$Y“C"KÕ±Hó��¬vù+¤øDr»Éj5?sqVÆŒ™.à´Á³Ói2Œ˜6?5Ý�°8Û•>7Û3/m~Væü¬Wú´¡È9s ñ4>ÛŸž�žµ�X_܆¸ ƒùg†_Ø&ԆɥL9ìCÐAô Ô ÔWР倕Ä<… ð@‘tjÿJNm4Àßà,| ×È©m‡Á}x ^XGÎ÷‡°Já/PIÎôWðwh…À·ð=9ÕOà2ì‡OàƒO¥SZàkøî©?Ázø3l‡]°>&Û¡ÜpNÂø.ÁõÎíðoa-l’öH1”Ã8G¡á38á*xà6Ü…ÉYa ä“}Sûà –öÍ)øΓ}sÚà;x� ƒl¦?Á6Ø %P�Þ§+S‰Th ºHÜïa)!ŠÉÒÙG–ÊXÅ Å)Å7JP¾®œ£\¡¬V>f{±£Øì^¶ÅgƒÏ)¯ªŸ*Yµ\U¯zê;ß÷a—Þ]t¹ÝUÓ5¾kV×»ÝlÝæuû´Û“îã»/ïþƒßk~›ýN«�êÿ0ÿµþ÷z éQÑ£±Ç•ž�=S{¶Ì ¸­Y¦ù)0&°VûŠvƒöxÐ’ [½Fõ:Ö«£wTïí}ì}òú\  ž|]7Aw)äµ�¦OÈ£¾]û®ê{7tLh¥ÞWŸ¢o5Œ5äNôcûÍê×Üÿ�þD (00aàaæ°¥ag‡†§„燋¯l5ùíâÃe!J!ä5i;X¼] ֭ꈫØ)*�Þp¼R¬À*LþÄ#bq»@…éM=aMeîB~`%^ÿq®kÉkѸ�Æiì÷åg¿»ª+ÝñÞÂi‹ãsôš£9 9‰3‚§”»ªOÔ?w(´´*§ðÝlâìÔÔ…ºÅk v–�,:­×¸ŠNï:³?¸1£"~Ìä ³f…®ÛXƒa˽ü¢epæÄ‘¹lÖ-ÕDq´jg“UX}YÔxßdÕ_¹Z=vÁ¨)Ö4´òJ­`‡ÂÞÎnTñôF£FâiÐv“£ÍòF»GÓ )ry;±ãa–oÃÙu$›Ü’U5’ÜcÕÝAÒVº=+׬ñ´ò£¥œw™RÎzÔyW»kªj^ÌVÿZvOåáãõš1ÜŽÄ ;ß´çpƒþ˜*)ñ�™#×ÿZ]ÌøÌÔ‰zõgë[qv+Îm~ù·Š¯ƒøW±I”{á¨oæ ƒ ßPàmB¨V¬ìĺ}p¥@ήX.$- Ø�Ýb^û…vMN"5_VL y9Üྯ[Á÷­Ðºq.s‹ä’,–‰eɸÌGòc?¾M!L Z··-Y¥®àÛd�kq¾XXy@,ĸçϬóÅämǬ™¸�<Šû3Xõ�ûÝïÏÜô`?Å·0\‡§j3]®ÌÌRWyyiiy¹«4S/>³Õþ—²Ñ�g¸qïç»åø>2¾MûŒ–ß”›&±«È6ÒP*¾±+¸é²Ô+2³ÛŒ|ÖÖÄÕ®ægÑÞ²Ô´Ü1òçñdå|ì!<õì¡W~•ÏÒ&&¹Ož¬u76Ö&'$$%'êÓ”WÏ5]»Û4|xì¸ÈÈsã®ê;uë¬tJ~tJÅ/Åæâ…õÿ!½êƒ¢º®xÖåÞEc�ìó­d×î[GRQ±.¢ÄOÔ(Ó ÇŒ¨D¬«QÑ ÐwŒEÄ `âGe1ë%«BLdT°Ö?¦TEÓD„¨„âõ¼—³[{ÖvúG;Óé¼y{ß¾{ï9çþÎ9¿sÞÓçÆÞ}òôéÕAýšA?X~öôÙUg…‹ðXÑŠ8Æ‘nÔT5l0å¬]œ8¾ù×uoI‚;é­7’Æs ×¥›…’¢ô¢ ›“ìÛd´æîo­ßsÕ�ùYæ!³àÞÄ·ñ´û‹£fØ€+oO*x-8sÇö÷wšŠÙ™úŽQ—ÂHÂ�¤býîœM¹y¹¹Æ\Gž£Ðs¬î†|î¨7ä}´ÍnKYñ¶öØZ3§.è ×!-CS¬êµpÄð˜Â5…DÐɘF�ÑXH#C(¬à ïRìƒ $�†Ô)îg”¯n®«ý„0•'2‡itÐÉÚFõ¹5Ê-\·‹¥N¨6â}@á¾÷Šˆs•÷ˆbè¨ ß×qà’ý p*áÚü´ðŸYƒ» ö‚^óøa&Â^Ñ͘Û-³U«dyÕ*&»¥žºÛÌën³rCT îññÛ_g¦Á1¿ÿàµ@9Äk.xh¹P‡üæ §Ëg°‘iJÕ)ZøÐÀ†ënÂFKi3n$d¨`“(æ¨ñd žx-S%ªDL¢p�8(‡œA3ƒ¯yÝî A°‚"!TèfjŠ(ßöYÆÊpEP¿x4¾_(–véhéùÚcç°&cŽD¯}¨ÐÝyf�CÞMÅ>†PÕô� ÊÝ“K�wo+ù¯4‚†ä3¥¼ñ�LSî‚F®¯Ñ5p0xa“ˆÚýö‹é0=ø§œìÊxÓÌ ³$=éØã,5•dØ ¥hõà@˜‘Œ±Q2xXÄê`F‰kpeaAi™©tOúÛ¾ñü†K3ã³m#rÌé8Ýþ:j3ƒ•m =r›ŽŸ9àõ{ªMÌ xÂg#ÊŠ÷•+"Ìõ¾G¼†^`š4€‰vÂ`g‘SøYù«–¥ëpdöøuL8šÓެ¶î’œàL§ãìï¬gJã‡ëK…¿ÿx7M%|f–÷‹^89[LÍg]åʈò¦©ê‚y\ø¼®�!�燼u¤‡çà/áL#N…iÉ0À<,Z†ãllïp`z L…™8̃{¥ŽÛL‡ ½µ¼W®Â‹0àâ_Àà� ÈâÖo^C“ûÇ¿ŠsÍ!ùLµ0 „rm—œ<Þ lŒj�P]{Ûz|i7·0É[%ßñYÆ,„k jê!H -f…kP�׬2T³hÕÒʰZnǬ‡šv†_É?ø,ãdNpiefÿ¾¿X¸jyÄðŠüÈg çó\|'¤uBJ§æ¼®}§¸ïI£ó0Ÿ¦ÅßåKú~<¬�|þ:kñV)?‹{¿å’ÑÎ'J®åýí RAO��¬¥ÙñÄëñf‹.º¿�(¯ÐL+_UÏ#œoŸD¼1´¸…?ö¤Ë?aX…ZøÎÀFA»<ØN"e8Ê’)ÞQÂà”.…2Š×ð� ÷~-ßóYFù�ÀéÁb\¬FùÛLÈârt�¨8yNqg;I”_X,Åí<ù6Rtð䛿‡ö(· ¬JæQÊ; Øn`£U‹Cøb‰“ × K�!_دd¨e#©àQ- yÌ%x«8Ýa¢REp“|ßgðVÏ¡ôLYÆ´ð±�E¨~¦[éGœjÒ]†ë䟼yü#E9BÐæw³µg£½\�-×ÔA˜aZå%»©0fA"ÌÁA‡©ü„q8a΂T©<c–B8$ÃÂã0b æ8Å…˜¼Ã1Fú—5ÿ8<ÔêýJŸŽïÍgÁâ7.·�«ÇŽ[ âÙ-n œ…m¼KŠ�fp@ŽÂø6è ?îüÿ-ô'öi76î…P-Ü1°apú‰¬ðÂe šáWp‚„-½þ¦°D�ŸP®|û"M]€ý¥‘~ŠèTn2Í>å‘VùÌ�™ÄÃñ�ÕTE¼…s°�çÆŸ”ÐsŸfL:,}N �‡ëGÙEY›�[rs?0{“3( ÷yDüÙâç¦^ø*8tJ¦�Eª–&ÝC×Ëo–I4æïEšŽs¸ªse®‡MM>°­»åÀ—ÐÉéê³Ù',¸é¨ø;±Õœ±èæBÝ&Âìè!Ò‘Õø"¾^ØãÜ6åq¹æ„*°¨ü¸±Õ5$°ª¿y¸¿„8#Œ®õH±è4ÆÍ°ä³¦ö3ÃÚȵ÷™Ê³Õ‚±´µµå!±á´¥=êA�³ù¥çW´³-/·F›ù½Ú¯mÄÙ$Ä’áR‚\°Û¥?Ú³Û±Õ‘§„n´¡²Ï–ðÀµþ&¶¡ÑY£U(à§jÓËkéÿ3˜V`àO�A_Æ`\+~aäzŒü«UÈYÈNlùØò?UÌÿ¶*^g±å‹ ïãÏãR(|0ΓãË>šÀȾ醨ë[nØ?¶ìíy÷Þ¡¦€é/Àò1—σ¸vÛð¼nvvþ,OÿîÜû39ßs‘Ù‚öå¯×\믥1—-ª_×Ü 1˜ÐøDÇÒù؃xüFç…ß®¶ûm,¤ÖX²œywßdoeú�á»],¬Ý:뢨vMͧ?È¡¦íÖ´~zrݾV@a¹žwbÍŒ˜±Àãd2ÿÍR÷ ,/z¼DÓH4q™!›|`Ll?sé<�EìPz]"[Ï7dÊ”RúŸ’`r»ôö¹8úÂý’¶QâDJz<…ò¢ñ¦’@Q>�5çnÎÞ’µS°Ûc¿×&r“wë[v˜\ÿjˆe�ðP÷A~•pø.¤j=ulà–¡}8äòwµv‰Ià¿ë� 0¯7Ê£,fÞМ/HÀT“n¤‡ð"4“ú²”÷óZ|°ôá›ÖVÛ6R’ˆŒR+–œŒ/¤Ïd*‹IìÕ×¥fûíML×\|8^ ܹÏéÐÁ÷uð½nº9 'ã€g¼¾?Ý‘õ’J¡à&gd¥d“E¹§JÃòÅŽÑ;×$Ñr×´Ýr;Ù"×@+¹ Œr˜…¿ªˆ¡¡1á.9c Ó‘e•檑=—÷§�—7 ®'E_p$ÅaQ‡Bs#‹²³é´"…+ñˆôÜJ ^¯béŒÊ@îÜJž¾û]5Û!¬×‰jA¥Å^]aà¦ÀÛ{Õ�Â>̉3¶GÓƒˆ³`öà3ЃéÆ�ç]¤°WÈðvTAQRpªér—¯_#åט'Î&�¦)•*KX€fÓØ+;g›ñ…Í yá×Î;¢©+Â/ܸ» �TÏŸ³±ZžÜ&7A¿�S ô˜IŒ#~$2øH4‰ÜD&C3žÌ‡Ÿ;•é•t;_êë-÷!—ˆºF�Ò ¹‰$¼çÙwÊî«N¦ªHýžd5ƒ©9u:°©›ñÿŽÜY"Ë.þH ‘°M?N+úWz‰sR•��4|ÏfÅ&Åz MO@Âõˆ& ø0¤RÕ8â*GÿE¼mzŸNݘñ>¹Ír.aäd‚x2J'|á—ƒD§W x¤2öø1åÑì4JsôDY;yºôpt}ײM®C‘û=Ì·‡Ž‰ÏÔä–Õ¦Qé­Š¾&¢ñ©Ö~"ÊòÃÊBœ¨X‘Ø8`µ …fnÛÁÍ$m<œlØ „¶†AtÃícS|J 3µ°A‹Ýƒ 3´ å=«èêë>í·”³å�­¬ËÈo¦#vñ¶»0Ïz—×– *…‡½îNô¯·'7øîÚ¬ Ë:šž–„>«È©æ0&â³/i�V3˜;DÂ;\Áà ߢe».“ ÕyuÇ~É–JS“¤É´49QNJ⋞úÓ eÎ0×ùƒ *b>¸,&“R¤ªÃ…²úºÖý¤°äë�̳Û�²õß°8>7°À³ú„#/Ö<g-ÌRcÃLà×þùðÐ_C÷Ú­óí¸@AÑ2¤Ç_–d&³bÓ›d•´Þ�Ø�)9[w´èõPzí¡à­×Ôúw‘}µ%Ã%´‚gŸ]ê2@Žä_í©–gÇ'Ê¢Si‡dÉ!7Ò5ªê"­oÀÌù÷ƒø  µ úCHf>6›Ÿ¨”e¶AØ�m[|µ‡8,îu𔿱Ðx‘�'Å|ÇŸŒËâ€AÂi†>Í©ÔAŒNÒ˜u8šbb�hd8jÁîÈSFGØäÒ&#h 2ñ^…â ‰ÌÌͧR [ËAT®÷y ;Ƙ3oñvKô]­æÝÎ=«î$ïòVÚ£ŸlïA5 ¹ueTOt3Ø â!¡ŸáÂ/Ó­©éxE#5´ïõ'ŒØš&¨ámCØWþ+U¿¹z¼^b#عÏúÌjü 4 é`Ц†lsdLÚ:º[£‰°r¹.•Nß�nïE ¹‡D6²ÃµªŸSþ‹½µNËü7¬L¤Ô¼³Êœžf²äD„'�æòçÖ&–\mªà?”WkPWf{šèeÛ°=Ú ¨h%£«®ÁŒp]]V4*∠”BÐaTÂCµ@Þ(è( ƒ ‚€¢Û¼T@d@)6($.a} F7êrˆî�ËJUöÏþ¹Ý§ûÞïÞó¸ç|çOÀrÖ5Ê•qEÉRŠ2,GlÀŸ)=váÚÓR\¼ •›“‰’'¬•­èòb#S,1 Â6bªg³¢>…Ò>‘Â(Ñ'8Ïä’¥°À°­¤ðúþP9°U¬g$ŽVù–\å}M[qvË–ˆ°ÎKï£f}ƒüU‘0úª� ¹ljüÑx_”/AWû{3aTCei]ç�W¹½A£î=~m*ú}PuGrõ,xo1;Æâ½Å½ b‘â^F™æÞù„½]|¹ºšËÎNOOgS“C¿ äƒ×¯™Çâ¬!àR¸ô¤îË"À“&>¼Á,±Ê.ÿ²õZ³ß-‰»¡d´Ê$�€¹qKÒ²8Æ2ÃÓÕ¿N§­Œ“Ä™¿DJ‰4Í|Ifšx:dÞô©‘§³îx ß1�¿cÚ xÒš%‚3“© KÑ(œüþâDZ®ÿÅÞ—\ZÖ£8}:%CÇ tü>mB4™ß^N Ìô\—|"þÄ!K±[1žÚ+éë 9§Ê¸‘I¦AÓH¡ŒÆÜƨ¡Å[Ȉ³˜ ­¶¾GPÒЪ¢[PÀá�(¨(°U£’¬VQÞ4�çÓV�‚i ­ 5rð#ƒÚFÒªá-ö3Øse¦™d}‹¬E#Ÿ`Šg‰°Þâ~¤1kUC+Î`&´Ð0òhú¥Æ•¤�Œ¨°šôJ¨ÁS ÌáêÌØJ5ÚŠGV›á8[-•"¶�yQß[Þ�QÔÀ8I-ÙÃÃH2ˆVÜ€ŒøO2Ä>≶Ù˸ÊL³ó³Ü´ÚË̸éã±ç°ìµÙœ¨–Z<ÎE¢Îs)1~U'¹dM·ôÜ`šk ¸ÇY EÙyúvÇ“kIªµ\‹r7Ãò¡=ü+mA”šõßp„[}$11š�Ë9Xöª±þn×Ϋ(/æì ÊjI©ˆ-†åD‹bù•Ÿ|­_—�%s"òXTÔ�Ø}±ÜºÐo6»*¼ ë¯ëê›ù‚óÑz…>'óÌÙ¨Ì]¼õc­6!Tž_\[x£™¶雊"ÝÉ¢^ÊÓÁmÓ’5»ëcyÂÕ^ºÇ, X̪züAÊY¿„ñÝíÍ„"Äê` „ÐCÉ­nˆ%YÀF˜çA$‡Oñ÷Ü£ÖæîÏç®'vµ(®eÍøÂ7Ñ÷€/X–$kÞçWá¡À1^h5Ë¡}ñ Ìiƒ0pà•È1óvà„«w_¿ 6Wú»îžñügß`C|ÑØZÍ€òÌ' O|«1õjГZ'>4´Uô°Rbô"Ñ>ºh+ Òøîïp …*ÁÚ™“©3_Q 'Âkªšö8¨Ñ‘ÌEJ„�'d×Ï`3ihD+ª9�Áwà@�£È’×ÔF²ÜžB=¦R>Dø™Ä™*ÞÁ3ÊÇ›ñœÜŒæ7CÙÉ€ gê* ™ ¤Dp…^rLjÐMUÁ…‚IjœN¢m‘ÇNázØÚKùš…9¢Æòþa¥c¿õu¸ÍÜ„IƉ/ Ò­¬‡±”utõ˜î[¼¡\(µì¯8wDþ‚%Êu¤äÞYDùÑ t®Ç±˜°Â¼«i-Ž£`=¼a®ü®›È]ø-Ý5: 1Ùb;ê®ß²G+Ãa‹‚t~%‹‘ŸoC;ëqr|j\JÜ?ÚGðêÿdɉéñÇcu–V¤îÜ铜Ó=‚…waá�tX ôãW¹lÕWë�‰çu²Žì ç…AæóuôJo-p{ÑVUÖšÅ%ËVdU¶*žÿÐóÜmØxƒúLÈߘæãúi?wö×諹ÒÓÿ(eË¢Šýý£H­Þ~zÓvv£f—ŸJû¢¹1íÚÙjÎYœaýæXœCƒ¡×ä1ƒõ†¼ß7™|�j´߈) )ä‰àb²±¡›"éÉà,þè¡H ¤qKÂV™lÜ)Èûú‡•ÖyÆÉ0ÀX_Lj&SÀTvR àKf„—Ý…ùð࿵VùK”Qµì½À({1¨¹ âÒ�•%SZní iÙ䤅Je8¶èD‹æ�•FEDQ&EÑbõµX�–‚äÒh¶XX?„QYqßp?³w]Zþ€~{ð¾{Îy÷ÝsÞ7•˜êž?V–»ëi½1õŒTW›‚>úØP Ó»ñ ˜ÄÐj�tžŒþLã�ÔK,£ø`¦0uÉé'¼¿`Y15¿dzH�€§Óæà†e(à+ƒ¦X`Ÿ‹N#Ld2UÓãùÍLzkØË îÅ‘�‹Oœ0²ïÓ:y…C•(3zê1�lÐË0R¾u‡ƒ…BãÀÊ EÃj^{4ÌSC’«j"1—áS 8øR40,±À–?Êû‡ý‹<,w ï.ˆÈ¢¬^œÆt? àì˜�‘ÿJŸþ·ôešžØ']húþbáVÅy®£ ’õ,4éá_•Ù¤!" ÝñýF3à°N§€•wt²¦r'Ä’Ïž½" =õm� €fc´îõ‘\Û;ÁŒ^/ѵÖy$/�Ëph�˜NâsS²Âet„sÞ€C™Ø#°»¡ìŸ(¨¬“¨Y>Ç볦±è<ÍÕáàI˜­½³Š¡ýX�„¥ò ¢¥)MÊ»ßÂ*Uƒ):‡0’óƒBp7î£(Ûún±ú1„|i°&«Ñ£ê÷P†ÁGÊÂz•›N¦X Z`ªô 'üìªú ­&ZÖ¼h‚((|H¬9æÛÀë2ôփ‰´fzF(m$-JÀ™l”C^è;¼Ëæ7†÷UP©ÍÈa.#ÆS”µÃ8Å)Û!X!öÑÔ_Bgìt}OeÇÔºU(€x ¸v§Ú«·c°j“Ú1±AÿÏ@^no‚Ú¦!½n6›Û¥ï—zÝ lnî°2Eú*¶:s­%ËÇzd뙚·îø_½\}ñä±ÒXCbé©;�µªŠË wíݹ¾( ¯¸`CºoƦÊ%%�ëêØµªcgÏùœÜvbóºíëÒ6ú[W/Ì0g–œ7€gqþ�$ß%Ùiqùm‡ÊKËŽï ¸²ÿèÙ¾×OåÌÛ0Ênw�¶Ï²s̶¯ôÐF¸ÚFËoâ³rß endstream endobj 46 0 obj<> endobj 47 0 obj<>stream H‰|T TT×¾ÿ}³Â°>fœmjô¨É,ÌòŒu9‰)Æj-\1GaDÅu¢˜ˆŒ !"ââ¢FFÀÝRmÔÔ­jbb\¢­UïÀsé{÷�IzZÏœóßÿýÿ÷¯÷ÎH†°#§d%'Κ’åH˜2s´£ÿ˜äŒÄDÑÑ߈¼¥à-Ã^7ã —yËý»¦ó�íÅí¹FÖ¤‘Ý ÔȯoÐô A É� P�ô¨ê‡LÈŽ¡wÐô4Å£ä@éh.Z„rÐ ´ • µh=ÚŒ¶¡äAÐ1t �Eߢ«è{t=@�/´¡„…ÐA/è&°Ã xރѓ`*$C*dÁX ¹PÅPU° ¶A4Â~8 'á,| Wá{¸ÿ„'ðcì‹1‹Õ¸~÷ÇfÌáÁx�cð8üNÄ)x6ÎÆNüváÕ¸Wâ\‹ëðÜ„á㸃/âkø|?d¬Ì™8fF´É`·Di·‹Ò"êœÑg4 öhAÍ¢#ÊHAÕE»™Z8c”5›8 µÐ|Q¢ä¨´E¨Ù+¸­R„=Úl¶˜¬4•“h7XD(gŠîDÚm’¤õ-fˉÕÄ–¤šb5Md¤5ÊNÑÊvZÌ`£)è„6Š·D‰±Ô™h‹M°˜L´ gô(“�Nc¤Å¤^8#íZ ¶ÒÞ9£�Z¤0Z†³Š©­Q4'xmi©!õZh¬•.Ä(-•n�£ã[éB8é.¨Ýf¡&º`3g§YéÈœ4 °uä÷b±Ó 9Q�®0öåÅØh—VqÜ(#G×cÝÒ&9©Y¡á¾:Þ„ôè¶­6Š1Q¯4–Ô%ݹ°±¸Î�8ƒ9:NhÓ.�Md5ÓÅÑá Vkê(J“X©”¬tRkÇMKÒ¨TrR>i�z’NGŒ’0tA6ú¬„–b;ß² ßNKŸŸáHJÎÒ÷Nè£7rœA?tZÚÔD}ìü̬ÄY™úá© iéiS²§½¡×�9S#â3õ1‰™‰së¯ÉG?Ú¡7ÿ—á’‚Pýä x úí@õ¨ö ½x?:'Ð×pA`�;{ü # ágø7´Á pA”Á§PµP{`€ó?œ€¿Â%¸ßÁOð�ò_òÈV�GöB3‚/áe’kpS`!;<ƒ° Ö@TÃØ»Æi�ÃpZá¸×áG¸Á Ï! ¡*a|;N:8é¸+qå®X ëa³À]u°vƒGà¯#ð| çà2Ü€[pA»@´+ápÃ:ØŸÃNøšà ƒÓð7¸ÿ˜î6Z,Ò1ƒäÈ Ðì-˜‡Kða&Œ±1£˜¦‚9-ë+›!Ë‘í�ý$ï)*Ÿ*oV„+8ÅDE®¢Eq[9B¹Méõ™é“ësÉ|í¾ßßVß;~Ãü¦úð»Öu™ÐeWâÿ{ÿ)ƒT ª9ª U½êV †æÞê4;¨6¨58%¸$øT„Œ ™’r5äYhlèœÐÒ0Ÿ°Œ°Ýaß±¿cw±·»>·‡� ÿ(¼2¼®Ûàn1ÝNv»¡Ž±,Âq.²0ò¤:\�¥AV³Ps´û¬î÷´}´IÚbm“®·îºÝV}W}JÜcZ�úž3U™*2¨Ý‘ {¼†¤óbKdŽFV Ÿ§àãŸï”ç)ôÄmO.\T¿V®"Ï-á䔇øy®“6ò3{‹ø½©äýx­¤‘%DËò1·HŒ‡�!ƒâùA¼ŸtÄÄ“˜7%ù!2„øI‡ˆbªB¾|S;Ù/PÆô½¶1¤¿7�%+W‘ww—¬ž³Ní...+_Rž= ƒ·ðKVè–?í.ç¯åÎOËÊY^=Oí\¶ìÃÅ¥‹«Žî=B~,ÔÑ”Þ÷kÚ´›BJk.Ö§Ô]ª }BÞð¾Ízr¶M96yÚ¤åÚ¤®“ŠgÔï�Ü¿½¡ùm�ldÎäIïE†¶�ø"þøR­+[þ4xÁÄ4ío*ìo®'m«uùWäÇ‹¿èç«”ªõsIª‡ø O²ÕC†ð¤’%þDÁû+I.ÀòãIf<ŸÉ+¤c|<ÏûK‡˜*é1Þ#ýÉx…JÏ—kde°­úh5Cd|9[-|ÎQ ÔðŽµÒº�y øÕ!8•�æsÕ̹—aª±’‘Ÿeª+QëA2�Ì�$sãÈ^øÔÎTÞä{Uðq|J$Ÿº��3ñ½´*²ÊÓâ�m½™¤˜=|¨®îÊÃG}¨/´ll>¢;©ó~RÒ€×zÞ}]=d|Æ„Xñ‘çTyk7y7WÁWµÍµL%¹ÍÎÞûôŒÒ½}KÑNõÎ-;·ëÖ)SËf¥ø´ŸWn-¨-ú¬Ìg�ÒéHû8Q�˜Vävèž¶*k½õlEnÅòJ—ÏóóÊ®…Ëæú¨ÈXÏÏöÎŽ.³;�ì:ûèî[$@}Ƴ¥á€î�2yrl°ž}/óêwãÓ¦�ÕµõæG±žg½ã•ªÂ¥mý �\gȱ¶žìD_ÿ¬Ÿ¼‰þÛ«4²ÿ0^5@Q\I˜­af,£›Ôn&U™!³5©Ä;E‹ÁDc¸+1`L„è ˜7‡ ° ‹° ò7n€Û,dAEDÐ;HÅäü‹?—ŠWæ®-/Gq¹+“³ªgèE®g (•ºœ5õf^¿×¯ßëéþºûý®É釆¼ÉŠoeÝÀª�,›„MÄqbúW¶u1=ö„€& KD+&Š˜ÐƒV Rþ=�X™ I°V„ךéK¤’¤ðæÕë°¨…Ý¢ÂáäG¶5/­!®c%³Ò26ˆÞ'ùxÅÚ²µ“?äã±ô6°ì¼8õ»ˆd¸¿-)í¬ÂÅê·°X½’±Õ…ϲ⯱³§²Ñ:³Ò²â>§^ËvÀbï°ÀìýÖ鸿ïö˜Ï®Óµþ7šð--žÿBḳ²µ¼Ù?â{´¥Î¥íT+&�†ÜÇò¿µ÷„œþïèÑ=.ɬþÆ{á~>•­@õ«èú€ÿ4ßãè(Õ�•Zju¼—?ëƒøT/ö¹ùUÞ¯Û[eN™ÓýeJ¥²‡ø@ÿíþëSÔvÂÓZ.œîUÝ—VÆ^õWÕyW\ïÏ¥© ïKÚãþ÷µ'dNúLµšÍT“7¸85žh6�£©Bxˆ ákXQiQ³„­ÛÓÞ}×�ÖÕån=xp{ëV øß×9¨¢h£Šá;wŸ›�(�0Ôv~|t� B¹—´1¡o|4N‡§26›‚ói¦Ynà¼ýˆ’ˆR†à ĉ÷*HËnËäŠ[»ì6€‘‚׬¯Ì,Ì_±}Fž8Þû,up“…G*k.|:#Ù¾l Bã‡wõò0C¨ð¨2_ýQÁG¹é)°�ó=¯kü¨íÇñÑù6˜œ¬S—+êò:“ÛÓæ1�÷a0»;±A.ç{œÝƒ"8ø“­M5rŸ\º&}•ˆµü–ÜÔw²Y¥@4rÔјºE\u>½»”¸Þ®Ik:)RÚseŽ8O8™#xLpŽ­ÈæÎßY1Ù¹w_‚m| üðYa}ZÖÛ»ä|¾»ü¼ëjùÃ�G«h#ŠS·Þ©Êí8¬~³Æ•\N\»Z³Ö‹èàcœÉ=yr)Ÿ˜—�#þd†fx™i†5„y£+ñiõ –[Éþ4ßBóK ¦FåÃÓÞW�Zc±¤ŠUv©2ýµ9î~ò”9˜)$få§Z²ùÏ�êÒ�Ey‹ÑëŠW#ø¥ìšš.±è�µþ<À ÉÇå\ƒvhäиœ´”3¯€2ßsò#b=j¸(%³à’³ïzÕé”ù-Ú’£‡Ë«£Nãû“qÛ!ŸRøáöd·Èˆ½Wƒ´k7®^Qߨó¤å ¯_x®C}N¹C¾ýä~ð3c>=òüh¢ú3Êãó à7Ø�~°M›ƘTû.¶“ù0˜Â^ ·8$ØäyA­å±ÆRZná Ma´»ÿʆ3®Kb|ÒøX¦#­)Æ•#3ZVÞãëLëiÝšr‹rŸä�j•EGQý_Lfªõ¯ªX7ÞÖy}&°íÕÐ -¬Oþ’S½„3�üO»óa±…´¥tµŽ„Vf~­îyAÎÆpÝ|£ÝšÕ:~}l}¯åô#�lém:Õ‘?¬‡r8¢†&ô`1PúH‰.Àdk4�BÙVT�mŠ”’¥h$%šø�õ[$…,ÀIf‰%Ê\�8î…å¦Å¡ÛÁ ŸÉžlÙÉœ¼að“g\—­…¿I_°Q´C·äÏ8X «6-ÒÆ¬ß•› 8tŸ»!?q¯&œ)2šRK¶iË™µÛbSãŒd踹êP«¶µjS‚Y�ü+˜Ñ'ŠC'ÂfÙ›-ÙmÚ[T ©}w«”¾Âê?Ša-W»wín�n½nû£à`•/0[ Nn/ÓÚKeÞ—úLªlY­Î/µÓ`9Kû$Æ/™¦Å6®C^ƒ Rh`‹ý\Š…b:æSÖZc}ŸR8˜d'“êeTô¨‹å 6¶{Ðiv,dš6c­6jmÖîuBÖÁ�ûr’Jú�ýSà—è¹Aȉ‰ÊŽÐÆÆe¤Ç 01gÿ¥òQ·w ôBr{Lj€™å>;ïÔ ?Øžê9J½×ÚÁó¸°½¤lG¥Ötrgv¡€Ô¶T¯Õ£V=nï„àƒªæϸÇÁwQ]ÃÔœ}W+G�*LÆvöFte€7/B繆ÏÊÍÊËã°/‘�[Ùrƒ»i¾t·”Ï ,EI”ñPT?$ÑA$Qa$L•)AºLñÏ3æirÿS3ž¡AûŠc=åþ; 8QÌÊN&°â«,=cÓL‰ÛЦ¨fÖôIè… ý賦óe `÷¸ÂLfî!-!•¬ì«‘ÜHúäË^ ¥÷æQAʯ2~ PÕö˜„‰xöñ@áçÄÝÄ'äS�‚ã({ñ‰%](/àGø¿&8壌D‰¸�V:Å�i ¾ `.R@Í(²AG•ݸZ~CNÿÒ6×d[© –7Hû]iòThD’Ò¦±¢J0«ú¤x5ÄJq,Ð( "µŒöÁÅ>°˜znMg!JJ'#d à )Œt!ÊšNÙ׊¿Š]bÅЧꑧ¨åäZr–3söW’#Šø”>û’J2×¥ˆÚvÑTÝ$43‘¡:ƒ�vUäž«„ºÔ¶c'Ò ßš4&íÌNþ Èóç¡ubîÜWíWúØK„¦ò¬ÅÜ¡½q}eB§þêh€îÄ‚·&›74 A8–Âb=ì¦C?¡p…¾¡ƒ‘&"jš„öõ£Äøê�b¿l»µ\†ÙâyQ%ñ¢ºòؖ檪n­(nøþ¬€7D¸À$ÖÕk´7Ï5Z„1þ«VÍÖ††>*@‡Ï3GÃÂ…k½—Æë{X"v+Ò³±ëbm/h¨7nIDßõð3D0@«ˆ­ fŒuâæóo Lvð°^€]zLa-Ó–‡=èë"RÆö·{àÅ(þ“þ×|¹†DEqœÔ{W4ý¢ÓÒ—$ÈLJ� ” ÌèCd�– ´¬’aŠm–(*ÖBšŠ-Zù„Ȭ4“=,Qz@%&Aô"B4Îìž:wF×u�­�±p9ÌãÜ3ÿÿ=¿{wÉÓ êÍÏ}I�³…©Ó¾j)–éܲ´«Æ1Õî¯V ޹ì´"'´Î�ZX<tY2tÑÁ ~à"è$¶h�UA qdÎNŒc®hY5rK ß2ŒkA—€JE2dÑCñäõ[ˆg‹³‘µYpxJÔs„8™¸Bð˜e#Æ+oXºÞõdÝ"Ù¬žÀÏ—">­‹‘q�/3|Ý ÓJŒÐ åÔ¾´Dƒ©ÒÏ‹] Á¤l Ö–ã >ç=Ó¬âfûÙ¯jò ªk La?‰œ„)¬e÷®[I^“¾Î;ùÒtËÐ¥5×yè$ŒF|ŒâÜÔlUëXQ÷­B XX/�´LcQj¥„!½(@`¡fB!A™¤ŸÐ7ü•ž žÔÖG×âkc=FLV ™¾<«œÒŠ1u¥?´c•TÃa³SbÅ×Î=d8Jð.!§¦´÷#žvf¬¸íÌ÷Wë¿H8 ¾ÇÔuW�Ï Á˜KeÍ\muf°lî¹PÓmz /_“dÜà˺՞Ö0ÄÔ8ß'Ž ©Ñe/5rëÍs`á¢Æ!að"‡º»‹‹î›0ËÅιN°Âþ~ë/™Í�×Í&H�2±#oÁ<Öš™Ù|È›Izê& <TMÇP†m2ÔòMh!¿¿‚…*øMG}wYŸ—9GëìGhùC-ª´±÷º‰í6›¦r›ýËÐ9Éൂý\u –óQH¤×w`"s…ÈààÙ± Gex³(°ËpŽoÇd*g ’™ö(­'öž=¶ZMÙYƒÅ\/{YÒÑQQrÇ„~h§<3p‘�z:TøÊëkÒ3šš2~÷&XÉÝ®ò¯Û¹Çj¯äšf ’Š]�gXKÚž©Ëi,Êês”ªI{-"zC–V3û}„Ì'� Г‡©yð�m?)‘íŽ.ÿÓ¤ÿÕÞa³9l6(°qì³” %Ø1mÒo§aHd endstream endobj 48 0 obj<> endobj 49 0 obj<> endobj 50 0 obj<> endobj 51 0 obj<> endobj 52 0 obj<>stream H‰|T TSW½'@ÁIã'�—°* }ù�«,TÀ¶Ó‚V>MDC* Z êªÚÑZÁˆ@Q ò‘Ê/J±ÎTÀߌ¨ˆvªˆGëÔV�qÖ <ºfÞ»égÖšÕYdÝõÖ9ûì³Ï¾œ È“‡`¢ÕÙë æÜtcD’!/7/Û²"6ÇdÒgsÉ©.䲂«�çÚêáçéÚæ7v“7¼vh/¸:`¸Õ?ÈóyàgAS� ÑJ–y£1H„& šˆ¦"Ò¢™(%¢$´%£Td@«ÐZ”‡6¢B´íAŨFµ¨5£“èKÔ….¢+èº�î£oÑè^àB„A8Р�ð$@,„Hƒå° ÖBl‚­°>�ýP•P Ð 'áKè‚‹púá܃Gð=ü†àß<>Ï—ÈÇ æ…ò¦ð^åEñ^ãÍâÅóÞá-à%óRyv^7ï2ïa‚BKkU E”š=uQQê…šÖ(J…J• T*Ñ£&%Á(¸ˆ"ŠÍêj®–f#-ùT³M'(U´š;µÜ©TÐÚ•R­à¾•4 a%­âN–DËѲ8ˆ[ iå¦a‹hŽŒÅI´VÃÆ9l–Žb…Ñ W¥ÒN%átó«¹*�–HÐ6ŽŸV©ÉhZ !ãh¿–T¹1n©R’.J’Õ�“¨b;rʉ6%áçº(9K9~™‚Ó¦tk‰»4ñŒ£×hXwÕ�;EJÉ(4i˺¦ÐpúD™òçkp›®&:’e1J•Š%#MYH�D‘~*rƒnšhBCîQM0‚Ñ ©âÆaÉÜ ±.šâ¾ îÊhš¨ŒŠ"HaP�on6Z矎ÍY³Áœ�µÂ"Ÿ¼lŠ\­ÓÉgeædä 6äZ ¦\yâêe9æ59æt‹!3R.Ÿe4Êçsø\ù|C®Á¼Ž�þ²Árnƒåy‘rnƒ æeÙlHŸ-�Öþ‚øÍeGà-_zCmÐ…z�‹ÇFà2\‡oà.»3;`C)f·ªN€:áOЗà*Ü„pÂçÐàïð1| à3°Ã18ßA+tÀv/@ïOøííè²£§à4|çàÏp ¾†;ðžÀ`”@TC4A|„n²Ç7à6܇ǰ ö‚ Ê¡ ŽB#´ Ùõ³pþ}ðW„¿ÁG°Šà ‚”Í=Pžì%e‘Õ¬„ø»æU3=–{Æ{æñùëù7½L^V¯¯Þbïïa¥ÏbŸŠQ3GõÂù.õ½äû£ŸÅïù˜˜1Çt <1‚=‚FÿÿVÿ{ü€ð€Ä€üÀQ�;Ï õÂQ€¨NlËwsÜwãýÆwNÈ•L—¼/¹.y" ’¾.BAaA‰A‹ƒN£`i0<;ø½à•”7e£:e»dÇeò/äw^îyùQÈ´�¤�C*C!—C}CCC§‡=™?±fâý‘çö‡mNÀ)®gCíØ&vŽ9õøþƒ¹ý‘2Q@Lƪü³LžV`^ŸŸ/Ýl-> °ì£³¦±äõi¥R�<™…"FŒG¯Ë’l¶nÎ__Vn¦D7¶”›�eéÒȹ³”êSOd8Ô†…íÒÊ¢Üôy…q)Y2A#»å¼…ÃÀƒÃ^ºû«Q8ogÔ[[ëêZ[�uFc5äù?1wâ—~u:ÜMàz†�?yþ±ïu‚k‰“M�u³Û°NìÄqì 16§bâ› Û¼#�®iW±î*”r§G©«K¬í�ìíŒïÕjããµÔձ޿íí͆ÔÔLCZZæ %0å�+û‚‡ë�QœÜ´¥Õ)éØWZAÕeX(}Öñxð‘žuS“k’Z­ûËXý±Þ�»÷–šbÝóËË’X­Vʔҧ‘Fêg½ªíˆx&ãXP'­Ø·q‰jKF2k+2Ÿâ~�ã®Hñ¿p*¿¤º¸Ò&9’[²6óƒMïn¥ Ì>°÷4ö·¸é‚Ô³ú´¥¾~°ä=¾P/³æŠCŸâ‰O±±°÷Ô7¤<+¾x¿yë¬=í÷J=ã±Òt¸ƒbÚ\2±h†Þ’žœ ]¶¦áTg+NtÖ–Ê>4}d�˜íëj«í‡�^~§1‰ñ gFG^ŸóðÖūת(Æk¤BìÒUó“½Fô?VóEgñ ü–˜¾4ç!Ó‡'`ôÍÒ3Ó/Mb|¨Ÿ§sb…õƼËd¬žÓÍ�ÎF×¹FlbòÄ›[¬mm’ÓE%ûK¨Ý;ù–½µJëð+ªêó›³e95¦ÍÇ%]_Ÿì¾C]pî°ëô©:XRY^Y¾¨EZ~èH{½¬öxuk™¤â5ÇÛ¦ìe –PúÙ)óÒ“|^a&E2ÚyÓî5Ef*sù¶EïIV²º(‡Â=x»Ï®ÁR¬Ãñ’3Ö3–ê#ÿ@V±á} óÈ3 3uwh†¸"#Ù¶Xʘ˜éŒšÙ0µsÒµ·eûZøsϯ¼wO‚õx2ŽÀ©-mÖ� ”€pºvA©«Šý?”ˆñ4Æg.“„‡=ðëŒÇ\œÄB}øÌB¯8¼$ŽY˜ì¸Ç¾ÉžßˆOÙÙÇ¥§Tâ„^L?õnq½>.Îy“ÿF«*ªó»,÷.…°é ½vã½QP)â£A‹XÔ¬p”7"àƒ‡B>€¬å¥�° ˆÊK@–u]„‚,¸®‚U(±‰^Ö¤Ñ�QbíÉÜÍ�žþ i´'§�3÷Î�æÿçÌ?÷ÿ¿™<ºõ`BS¤…޶¶œ•Ý /�×�VÓX_ÇÒVoΈV¨“›¤Í-ªê³ÜÑ\<<¹žÒÒ¼ÌpŽŠ W£„B›ß¹9n”¦g•×–(K¸¿@,eÕ4GñÓ{¼ï·×ìÞºt-Î]³#õ£Ö°¯3A)A›}¥þÉÍœUwæ�‹°l¼ª-+•ÍŠÊ —È+ÒÎÔŸR)û5ëpÆ’Ù¿qéð~8ÒóñÍ3¬¸ÈßP/¨7ÜÖóÞ £ßBì‚�A ÊBƒ…´\��WɉÒ‚ëøN+€`-,2>BÈæ ˜‰±áo¾ó°·_é±`ÁÊá ¶xÒ“´Ô‚%8hÑ\ið5ÐÛ?CK´´w@1ÒA˜Å¢+:ˆÄû•pM™cLò`jÌ+Ø@ªÒê3þÏ`ʬîñ‹[0kü“„ë®N(Z�³Ø�w™ =lÚ­ Šp‘á/lKTw±XÀÿ‚\§—iù)%ÜÿJ ¾>yœá7*¨8zró”T:DðãBC ¨Ýäx˜H\“<­‚ˆF¦1Ê¡*±¢±+�TÄ +�è㈉—OŸ¾Ð½x*àƒžþÉ@8“X›¬RÕÖ¨Õûj’’ö%'²ø�éÏtb�éàW/#‘M;àÇaÍ�1}¨ƒ�€OGÌ3§½«àmFþd¨ÿ0ôGU¨h1¾¥„µJþ×JP zÁí.«€*¥�ÁZfäìþöZ]pèâM‚´l[ —àcfßrr¼/¥¿Ûæ/EMЭ]/y|y³³åê9NA¯;ÙøÞ€œÆà˜ ÛЬ1OàrCÏ�\D£‚9˜µ~ÍeUP«gÛÅ£‰‹p>©ÊrÈ!‘n€,Ø ñ5 œ½ßÁ×¢R«Õ¥Ešcjî´PFðòè„ÀN�ÒÈ…JþÆ­ÃÐPÿ�ÑQŸ«Vùlpc;gviµ]]ÚˆÀÀã«íš=7h<©,y7æ„PÅ奵•eòɽIYq9l8æRÿšX:aÛ™ëgþG-˜’2_ m-Цò·#˜ÈóiW‡$JNU³ºt&À`_ÿàè–×gœ˜ºƒIðp°‡;š8¡©™«Ãw7‰wŸÏ sRÀY'­.y?jUšä@"3¨í¹ÐÅŽMÜïŸè·¿ã�Ü|²Tqä[Û�R›dv >úp‚ôm·ë�^{ò·�µ^a1‰)\rÕ:EnƒYé±’ŠrIœe’>HO�“¢-™US÷wð •ßÑ‘ß!íì((èä q²�I‡å¹íòÓñµ6è âÞ:Å�~fs6—Rå×¥¦J²ó³ó²ÙC¹òßŸÞ ‹’4Õ…c‹ Jóu(³Ù|Ù¹nEMa•udq®œ*Žˆ<î)õŒ:xh+—[•]˜JÂ0o‰üøî#{ÙìœZõ!p>q&¦›Ê 5eU±-ôQÅæÞ=ÅÖñûäûs#Óq¹µ¸ˆŸ¯ž‚mžâç3wáÉò¡ Œd9îc.Ió6X„ÛpQžâ>äb 8�L»«ÿ”�ÒNA¼�ñ#äÝy)s45¥0Yú#f‹'ª[N<ñçaw¼š¹oáˆ* 9äB”Í©²È�ð[™÷lä%ëƒ]÷º½oS¸¿WÑ[v­Ê¿šŒþy�˜BRcc ¡}LŸ ²�„Ù}}˜=-ˈd$"ÉŒJl žc`;&P¢…ð”“[:m)ò±z%ö´'¢ïÂ.Š˜^Ì¥ÕcÎ¥õ`ûr`´,ššE¼2°§WRÄÙ”k{Z´UkðРι–�‚Ô“0öP`KºŠðñÑøàë¬&�éòÕ¬\"Á´E wv«¿âÇâZ4g4 üÌ©�ý_Æ<—Âp!§}×DÌøÆ,À"AƒhAõ®[Ü4WŠ{ÐWá®yM‹{}Œ÷ê�–wÖ ÔF.TÃ8ƒP(„Y„(Ò°pÀ!ù’>h=r¬v&P�#õȉ¨(§iN4¬X«¬À=¿^/„ÆÇ ع+D 'í‘ý¨-ï$’‘ˆ´Óh1–ŒŒç0{.³óLbÝ>•ª®V­þ'ëÕÅ•……qfˆ¯ZíjÄîl7QLÖ$Zƒ®V 0+T4>VJ A P˜a�á5ã¼a3ïHÏ8 :”#†Á€®E£Æ@²!ºfѨɖ®¥ø(=ƒ·ö¶l¶jwý•Ê|Õ}ºî­î9Ý÷ûÎw®¤±¨HRŒ�eœ9s2,ÈŸAàHdƒl”vŒlÈÁê³!‘�#s2ᇦ€ c5JAÅ|”aðãÅ ,EY|zYø²ïj0ìÛ L - ¾…H´;Ø\X�1o6À„#Z��ÇÑ&‰¿3ƒÕ‡Á`•Æcð1ƒ�gB;o�74ñÇO¿¾(ÍDÓúÀ´¡+ŸÝ¯c—‰6j¶ïø#—{ÆÝié»ÜÓ²ó;_@èo‡­íçaí�=д‡v‘(ò Óaú‡›±Èh‡¦£éÑhŠd¸4ÜÆ­8ˆn¿É…¹oâÍ¡hî?pi€þ“äimÆÇèäMoü®7󫞇¾t²¢:éžô»ß 6þ¤ÕSºÓÁþG…àeZÒ…Õ‡=èý±b"4ÆAŒè8¯aHÓ‹P÷X1škX4–=¤¶þÐz�ÏÂ{@xâV@¥¡+dŸ¨Í]^°»X™Ç®Ã,þå¯ô"IˆèŸBÂÏEë`’ðcÇ�¦ õY~K<3á~Ø621ì6ˆÞ Y¹¯œóß»“ÀÆ\…å�s¶�®­s¸XGµË¯?:u�²íµHßFöWPÚÅà5|wñ=]]ý‘‘uß1PÔ…KÅ(7É i}u�šU™*ò�tš‘Ký7±�òu\ I(»�’ ¤ E8âò/Áž‘ˆ¤|OÇv³²4ü* P:Ó0øñôç¬ç .ò{ümþ�ÉÓOÔ?-&‰©a1]/3͵#�Εé˵,1a@ºW[)§+³½¾¥lã"µ/†ŽŸ¥SƱ«T…ò\*·±´£gÀlê`ŒÕB¹N�§¢¶Ô�­fªÅDݤR…ª¬œÚÜPrÞÌTUhÊåT–O6ÔvÐjidˆèpK£Ïz„nñéõ^–HÓ7xµ:àµÛêY;ç²qgWç0:9·ÁMãLÝVûi–Xµ°èk2V¯Oßn°52nc“ï«r˜ØMµ÷ZlõvM‰‰±¯²£ð%Ô³w œ,�×ösŸ‰5y€´:i‡Õêpj,Š(U§Nb‰wmv³ÃEÕ«jS7BûmúÌ÷ÅwìÕ*Ï–p*K•©"ÂTâ@/m¥Ö)Ò2¦L"©Ê§ K,æ–ˆo–I-ytŽD§•°„;_+‘è²éµZ·¯‘s9�¬Éw׸ŸÞg·¸ìZ«šEi¢•Ç{ ¾¶ÖÄšÄÑ^›Õ‰çTìè;0›äjùŸ¢¼L¡T(.7æäàjëO�0S’ÿmÿ0# 0ñåf9L]�S‡°h–£©C¨cê´œ×æHì„m‰Yh Û0ðàæÖƒ_Ö?¼�Z7yRµav=òö`j!"!Á5L®·ªÝŒÛm✎ê:ÎðМK£æXM½Wͯ·ÕÜ€¿áoÌ^Ÿ¹…>âÓêY¢.J×xPÛFù|� WUÏž×74§8•»´–1Љ Ú³ÆZÿ§”CÝ,·0F£ÐÐ1 ï¡;÷·¶zV9XWÜ,K<ƒ¢*‹±DX‚liöžJZ®Ýw`/Ëieæ\:M­Ê3`â%T¡— ˆþåÿš$–m²C¸ýÓ`Â<¤m½ºmlF9šøžÌXXF4Û|GºÞ|�O2Tƒ)¦ÒjÕ{mZ/÷¸FßÀÖêRj�J^ÀàuVã9¥]·oÿÝjƒ�uVsÊbJ¦-[›-±X%XÑV‰Ä’CçIuzK¬lÒ—”è é|I�[ÂJÝÊÚ>ªÃ/™S½¥Žs üðÕºˆÚï¾·�¡oƒP]5Ȫ5*U¥4«ljÆž„R-+h…F·WeÕ:œ@j ÖgàäET¾¼¢€!Æ  SìgjýL5ìÆÇðn@ø heà>ïÚôt~X_Dv  MäÓù™ÿœ/†]‘cSR•_löÀytz¦A*¶†?ý�‡¨‚Sp�…¸í wˆ#Ø&H$�ÍeÐ1t� Ñž"Q¬äÀE O‹aò¡g-6m÷HXÜmn ìÆ]}šPámV{臭W~´³r‘.¿ti–%ÏdðVžÄÍqfT�(Iò·5ý1Ü £ø†~"êñìn´”/o]? Mf‰÷F“ÅÉRi,“‹M/ºÞn ‰ZaekXÿ%`‡ìÍ‚‘™!9Yºóû¨r«/“F3Ðd…¦Ï;{ÿtw{wk­µ^xІù?á-hD Ñ^îAM]yçï Õ· ×?’6™QguÁJ»mqtA¥T„j}A„Hy^ v¡ò �DPJÀˆÄÇ`«³›u»�ßM~÷JËvZ‡>œ;sçÞß=óûÎ9÷ü~çûy õÔcê¨=Ÿ5 æÄÕ¯”»yÖ)ΔÓsb%Ì‚}ð:EŽí §Í’9¸EþˆLϨm¬¬0éO*?…VÖÎâçÜàÞï©�ß¾j-fxF¤{®mðAÛž¶„^0·I†-ÂÓ˜k‘^±Ž~Å…¤EmY#ßžÒ~êL7Ž4Þ·Où×Ä¢X™šÏh2òõ-—×v£ËÜ…8Ýã/}ùùÅ¡«� {–ð1—±�N¸;{§cÂÓçÍÁ'”ÒyËúnœnnjoQh‰ô©¨ Óžnyç@{£‰®–؃X3B¬Ml¡+´ƒ]²qå+;å¹yô*êõG•w €•.Æ{´‹¼÷>„~ÖQ“˜øjn Ü‘aêpà&˜ÌŒ�bÁ6øˆ šÌ`¢A¤·04‰)_F ‚d�y׺Tß³9��m(aQB°"”ƒçÉŸQÑ› aé§I/+Hí ‹¾„úm¼Æ^žû06Š&˜ô²šì e!`<õ‹Ô©~*Ð15 ÁaPq Cz‰6WÐ0Í‚fjØçzRfÚmÞ"ë['ÇNç 83%83«ùŽà„•(10°Ó ÞxÙ,²¾fÝÌy‘UŠÉ_ ŠýS6é(©(Ø-à ñ®‚}ªbE¶Å ŽÕTšd°E+¾�:VO>ƒÚœC‰:¿(±D‘ ®qRYÞ~£ ‚ÅÆƒû[Êö/žåjHeõÑA� &Š3 óc#e4YYaEÝÆâwKjc†¹Ô�üÿ°¨&ßO²…¬1øÓ8àÏLáÏÌê&à#mÞL‹,j)c<óø(V3uƣݥÔ8ÑqŒhQ‹­¹¾nͤf Á"Š_�‘¥¨Á´v3½ÖîÉÔ4iMÂ$Çäß™˜ü;hÙ2±LD,h™/v8˯ÛWþšÃXþ{ªxpï fá,—£)ÎÈÊÞÖõŠ�—,¤v{Öµùà¢Ìy‹UeÅ«cåÁ)û-o·h?¤¬!`X¼ƒ ~5gLÞ•BýÍèÑ4�׫›=—›3 0ͬáÃV %Ÿ™§F̱5†K­Ò¾.ð„»Ì4�„²üòòۼ¸§>=B) ©ß^•Ür¬¶½U§È&Yš¢=¹ò¼âýG‹”ydÜVI]½´/丮¯ö´ìdï«@·lÒZRQ˜%ÃM⬂BZ¤ÃË5(7škS“’“¢I·¼ùëçŒIMç<(Іú*Fs�DxÚæÍ&´=YÙlùaKN‰wÆ`†áÁ‡‡çyK—„òLàe˜q5r¸™¿Ù%} 6!�kÐWSHGë‡Z“ÂâÒ|”*‚ogþ.Û ¦áV"yòrYá�NHÄÒ(¿Vr¾-mÅ‹Æô� GúÎj•©dCanV†|wQíé|ež9êLXµË~±T�{N;ÜvIöÉbS�£SÉßJÊóãdØ Ž+Ì*Q8Ú|<”3ÕP.ª¦Ëñ§Õ¡CCƒW®¬ XºzÜißqtè[c^{Õw]ÜZEÖ­‚ý±4ê›Pò›\ü�㿸Ñ?XDíŠÓ¢ºQñ==ÇNœP‹ŒTÅG9 *ç>Óv³åÔvœK6¦™³¢ÆÆæf³Üã®±Õê´»å,›=¥Ø„�<} œ/‰è¿u8È—2öø•±ó ­J íÎÖ`îAS«µiˆÇ±2[ÑÝ>ò·2¥})�‹¢j„ÂGD´¢¿æ¼  «F Š‘Þ¼°Š6\µ-†ÑÛbDz8ÂÙbì{Y[̤¨-…†Gc„½ì¨#<…“ }ÉuÁWø–V”ýI{/΂vm'ñßçÄxξ×!6Ãþ44.Ð8բßzèyØý¡“ÿÅåô©æDþ( ß/6ëá�‰›ô[?á_Ã\ÀÝÎë/lôè �IssS2ùÞ–{�…Ï©’£e©u™Fc]¯�öûu«š o)Ò.´¸÷Êù†:~È#î…~åõþ»qC2©_.Ÿ^—‘äž¶NQ~«£¹[ÆgÖ©Õ™™©ª‰îH.NѸ.é^„œ §¦g¦*±KØñÿòsœ~^þ§GÊKœ~^þI§Ÿ–·ÿH^óùó�–_óyÿŸ”§ç…àÌ3‡„F¤ Î\x³ZÒ�Þ,Ì-&8Ýç Î+.FÉm”.-Öž¥^hÆ'¬VÈs´º¬Å`ð…iàƒÓBhù.7÷Çpê÷fæ¨õC‘À îÜÇPN3ÿËY¨¡™U¸à:jhêhðÄhô,Ö^ ÆÁš}y3GmPÈ"ì‡Jjp*qí"è§Ö(„Å+dœsÇsìoÛÖ¥¥ÖâR‚™¥bó Û^7ÛÜÿ£o]Ò endstream endobj 53 0 obj<> endobj 54 0 obj<> endobj 55 0 obj<> endobj 56 0 obj<> endobj 57 0 obj<>/ProcSet[/PDF/Text]>>/Type/Page>> endobj 58 0 obj<> endobj 59 0 obj<> endobj 60 0 obj[58 0 R 61 0 R 63 0 R 65 0 R 67 0 R 69 0 R 71 0 R 73 0 R 75 0 R 77 0 R 79 0 R 81 0 R 83 0 R 85 0 R 87 0 R 89 0 R 91 0 R 93 0 R 95 0 R 97 0 R 99 0 R] endobj 61 0 obj<> endobj 62 0 obj<> endobj 63 0 obj<> endobj 64 0 obj<> endobj 65 0 obj<> endobj 66 0 obj<> endobj 67 0 obj<> endobj 68 0 obj<> endobj 69 0 obj<> endobj 70 0 obj<> endobj 71 0 obj<> endobj 72 0 obj<> endobj 73 0 obj<> endobj 74 0 obj<> endobj 75 0 obj<> endobj 76 0 obj<> endobj 77 0 obj<> endobj 78 0 obj<> endobj 79 0 obj<> endobj 80 0 obj<> endobj 81 0 obj<> endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj<> endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<> endobj 91 0 obj<> endobj 92 0 obj<> endobj 93 0 obj<> endobj 94 0 obj<> endobj 95 0 obj<> endobj 96 0 obj<> endobj 97 0 obj<> endobj 98 0 obj<> endobj 99 0 obj<> endobj 100 0 obj<> endobj 101 0 obj<> endobj 102 0 obj<> endobj 103 0 obj<> endobj 104 0 obj<> endobj 105 0 obj<> endobj 106 0 obj<>stream 1 1 0.8 rg 1 i 82 708 448 48 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m f 0.2 0.2 0.6 RG 1 w 10 M 0 j 0 J []0 d 82 708 448 48 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 10 0 0 10 293.9801 714.9999 Tm ( 277:1392-1400, 1999. )Tj /T1_1 1 Tf -20.498 0 Td (Am J Physiol Regulatory Integrative Comp Physiol)Tj /T1_2 1 Tf 12 0 0 12 89 725 Tm (Britton )Tj 0 1 TD (Nianning Qi, John P. Rapp, Paul H. Brand, Patricia J. Metting and Steven\ L.)Tj ET 0 G 89 687 m 523 687 l 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0.6 0 0 rg BT /T1_0 1 Tf 10 0 0 10 307.0895 691 Tm ( )Tj /T1_2 1 Tf -21.809 0 Td (You might find this additional information useful...)Tj 0 g /T1_0 1 Tf 6.86 -2.8 Td (24 articles, 9 of which you can access free at: )Tj 0.6 0 0 rg -6.86 0 Td (This article cites )Tj 0 g 29.935 -1.2 Td ( )Tj 0 0 1 rg -26.335 0 Td (http://ajpregu.physiology.org/cgi/content/full/277/5/R1392#BIBL)Tj 0 g 8.342 -2 Td (6 other HighWire hosted articles, the first 5 are: )Tj 0.6 0 0 rg -11.942 0 Td (This article has been cited by )Tj 0 g 3.6 -26.2 Td (\240 )Tj 11.915 1 Td ( )Tj 0 0 1 rg -2.5 0 Td ([PDF])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.361 0 Td ([Full Text])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.054 0 Td ([Abstract])Tj 0 g 4.749 1 Td (, October 1,\2402001; 81\240\(4\): 1599-1658. )Tj /T1_1 1 Tf -4.749 0 Td (Physiol Rev)Tj /T1_0 1 Tf T* (H. E. De Wardener )Tj 16.086 1 Td ( )Tj /T1_2 1 Tf -16.086 0 Td (The Hypothalamus and Hypertension)Tj /T1_0 1 Tf T* (\240 )Tj 11.915 1 Td ( )Tj 0 0 1 rg -2.5 0 Td ([PDF])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.361 0 Td ([Full Text])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.054 0 Td ([Abstract])Tj 0 g 11.11 1 Td (, July 1,\2402002; 283\240\(1\): F134-F141. )Tj /T1_1 1 Tf -11.11 0 Td (Am J Physiol Renal Physiol)Tj /T1_0 1 Tf T* (J. Titze, H. Krause, H. Hecht, P. Dietsch, J. Rittweger, R. Lang, K. A. \ Kirsch and K. F. Hilgers )Tj 36.527 1 Td ( )Tj /T1_2 1 Tf -36.527 0 Td (Reduced osmotically inactive Na storage capacity and hypertension in the\ Dahl model)Tj /T1_0 1 Tf T* (\240 )Tj 11.915 1 Td ( )Tj 0 0 1 rg -2.5 0 Td ([PDF])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.361 0 Td ([Full Text])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.054 0 Td ([Abstract])Tj 0 g 13.138 1 Td (, December 1,\2402003; 285\240\(6\): H2670-H2678. )Tj /T1_1 1 Tf -13.138 0 Td (Am J Physiol Heart Circ Physiol)Tj /T1_0 1 Tf T* (D. M. Fine, P. Ariza-Nieto and J. W. Osborn )Tj 14.75 1 Td ( )Tj /T1_2 1 Tf -14.75 0 Td (salt in rats with clamped ANG II?)Tj T* (Does whole body autoregulation mediate the hemodynamic responses to incr\ eased dietary)Tj /T1_0 1 Tf T* (\240 )Tj 11.915 1 Td ( )Tj 0 0 1 rg -2.5 0 Td ([PDF])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.361 0 Td ([Full Text])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.054 0 Td ([Abstract])Tj 0 g 4.749 1 Td (, April 1,\2402006; 86\240\(2\): 709-746. )Tj /T1_1 1 Tf -4.749 0 Td (Physiol Rev)Tj /T1_0 1 Tf T* (L. J. Mullins, M. A. Bailey and J. J. Mullins )Tj 26.055 1 Td ( )Tj /T1_2 1 Tf -26.055 0 Td (Hypertension, Kidney, and Transgenics: A Fresh Perspective)Tj /T1_0 1 Tf 0 1 TD (\240 )Tj 11.915 1 Td ( )Tj 0 0 1 rg -2.5 0 Td ([PDF])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.361 0 Td ([Full Text])Tj 0 g -0.5 0 Td (\240 )Tj 0 0 1 rg -4.054 0 Td ([Abstract])Tj 0 g 14.611 1 Td (, December 1,\2402007; 293\240\(6\): L1369-L1373. )Tj /T1_1 1 Tf -14.611 0 Td (Am J Physiol Lung Cell Mol Physiol)Tj /T1_0 1 Tf T* (S. A. Hirota and L. J. Janssen )Tj 25.251 1 Td ( )Tj /T1_2 1 Tf -25.251 0 Td (Sodium and asthma: something borrowed, something new?)Tj /T1_0 1 Tf -3.6 -28 Td (on the following topics: )Tj 39.984 1 Td ( )Tj 0 0 1 rg -18.695 0 Td (http://highwire.stanford.edu/lists/artbytopic.dtl)Tj 0 g -6.387 0 Td (can be found at )Tj 0.6 0 0 rg -14.902 0 Td (Medline items on this article's topics )Tj 0 g 3.6 -7.2 Td (Physiology .. Rats )Tj T* (Medicine .. Hypertension )Tj 0 1 TD (Medicine .. Body Weight )Tj T* (Medicine .. Diet )Tj 0 1 TD (Physiology .. Blood Pressure )Tj 0 1 TD (Physiology .. Plasma Volume )Tj 10.175 -7 Td (including high-resolution figures, can be found at: )Tj 0.6 0 0 rg -13.775 0 Td (Updated information and services )Tj 0 g 27.157 -1.2 Td ( )Tj 0 0 1 rg -23.557 0 Td (http://ajpregu.physiology.org/cgi/content/full/277/5/R1392)Tj 0 g 6.678 -3 Td ( can be found at: )Tj /T1_3 1 Tf -10.278 0 Td (Comparative Physiology)Tj 17.193 1 Td (American Journal of Physiology - Regulatory, Integrative and)Tj /T1_0 1 Tf -2.472 0 Td (about )Tj 0.6 0 0 rg -14.721 0 Td (Additional material and information )Tj 0 g 21.321 -2.2 Td ( )Tj 0 0 1 rg -17.721 0 Td (http://www.the-aps.org/publications/ajpregu)Tj ET 89 189 m 523 189 l 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g BT /T1_0 1 Tf 10 0 0 10 89 164.9999 Tm (This information is current as of May 20, 2008 . )Tj T* (\240 )Tj ET 1 1 0.8 rg 82 16 448 54 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m f 0 g BT /T1_0 1 Tf 8 0 0 8 296.3279 22.9999 Tm ( )Tj -9.805 0 Td (http://www.the-aps.org/.)Tj -16.111 0 Td (ESSN: 1522-1490. ÃÛÌÒ´«Ã½ our website at )Tj 49.648 1 Td (0363-6119,)Tj -49.648 0 Td (Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright \251 200\ 5 by the American Physiological Society. ISSN: )Tj 0 1 TD (from molecules to humans, including clinical investigations. It is publi\ shed 12 times a year \(monthly\) by the American Physiological)Tj 0 1 TD (illuminate normal or abnormal regulation and integration of physiologica\ l mechanisms at all levels of biological organization, ranging )Tj 37.752 1 Td ( publishes original investigations that)Tj /T1_3 1 Tf -37.752 0 Td (The American Journal of Physiology - Regulatory, Integrative and Compara\ tive Physiology)Tj ET 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S BT /T1_4 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg -10.06 0 Td (ajpregu.physiology.org)Tj 0 g -8.114 0 Td (Downloaded from )Tj ET endstream endobj 107 0 obj<> endobj 108 0 obj<> endobj 109 0 obj[107 0 R] endobj 110 0 obj<> endobj 114 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 17.96 0 0 17.96 48.569 738.72 Tm [(Body)-366(\257uid)-366(expansion)-366(is)-366(not)-366(essential)-366(for)-366(salt-induced)]TJ 0 -1.222 TD [(hypertension)-366(in)-366(SS/Jr)-366(rats)]TJ 9.978 0 0 9.978 96.463 680.913 Tm [(NIANNING)-366(QI,)-366(JOHN)-366(P)129(.)-366(RAPP)129(,)-366(P)74(AUL)-348(H.)-366(BRAND,)]TJ 0 -1.2 TD [(P)74(A)55(TRICIA)-311(J.)-366(METTING,)-311(AND)-366(STEVEN)-366(L.)-366(BRITTON)]TJ /T1_1 1 Tf T* [(Laboratory)-366(of)-366(Cardiovascular)-366(Research,)-366(Department)-366(of)-366(Physiology)]TJ 0 -1.2 TD [(and)-366(Molecular)-366(Medicine,)-366(Medical)-366(ÃÛÌÒ´«Ã½)-366(of)-366(Ohio,)-366(T)89(oledo,)-366(Ohio)-366(43614-5804)]TJ /T1_2 1 Tf 8.98 0 0 8.98 58.547 620.286 Tm [(Qi,)-299(Nianning,)-299(John)-299(P)129(.)-299(Rapp,)-299(Paul)-299(H.)-299(Brand,)-299(Patricia)]TJ -1.111 -1.133 Td [(J.)-250(Metting,)-250(and)-250(Steven)-250(L.)-250(Britton.)]TJ /T1_0 1 Tf 17.367 0 Td [(Body)-250(\257uid)-250(expansion)-250(is)]TJ -17.367 -1.133 Td [(not)-239(essential)-239(for)-239(salt-induced)-239(hypertension)-239(in)-239(SS/Jr)-239(rats.)]TJ /T1_1 1 Tf 26.135 0 Td (Am.)Tj -26.135 -1.133 Td [(J.)-435(Physiol.)]TJ /T1_0 1 Tf 5.425 0 Td [(277)-435(\()]TJ /T1_1 1 Tf 2.436 0 Td [(Regulatory)-435(Integrative)-435(Comp.)-435(Physiol.)]TJ /T1_0 1 Tf 18.421 0 Td (46\):)Tj -26.281 -1.133 Td [(R1392)-56(\261)-56(R1400,)-287(1999.\320T)92(o)-287(evaluate)-287(the)-287(importance)-287(of)-287(volume)]TJ 0 -1.133 TD [(in)-570(the)-570(development)-570(of)-570(hypertension)-570(in)-570(inbred)-570(Dahl)-570(salt-)]TJ T* [(sensitive)-521(rats)-521(\(SS/Jr\),)-521(we)-521(measured)-521(the)-521(changes)-521(in)-521(blood)]TJ T* [(pressure)-230(\(BP\))-230(that)-230(occurred)-230(with)-230(oral)-230(intake)-230(of)-230(food)-230(\(salt\))-230(and)]TJ T* [(water)-369(in)-369(rats)-369(whose)-369(body)-369(weight)-369(was)-369(permitted)-369(to)-369(increase)]TJ T* [(versus)-308(those)-308(in)-308(which)-308(body)-308(weight)-308(was)-308(maintained)-308(constant)]TJ T* [(with)-304(a)-304(servo-control)-304(system.)-304(W)55(e)-304(hypothesized)-304(that)-304(if)-304(volume)]TJ T* [(expansion)-424(is)-424(essential)-424(in)-424(the)-424(development)-424(of)-424(hypertension,)]TJ T* [(then)-243(BP)-225(would)-243(not)-243(increase)-243(if)-243(body)-243(weight)-243(was)-243(held)-243(constant.)]TJ T* [(W)55(e)-228(found)-228(that)-228(oral)-228(presentation)-228(of)-228(chow)-228(containing)-228(4%)-228(salt)-228(to)]TJ T* [(SS/Jr)-199(rats)-199(caused)-199(BP)-181(to)-199(increase)-199(32.2)]TJ /T1_3 1 Tf 16.97 0 Td (6)Tj /T1_0 1 Tf 1.032 0 Td [(2.9)-199(mmHg)-199(over)-199(4)-199(days)]TJ -18.002 -1.133 Td [(when)-294(body)-294(weight)-294(was)-294(controlled)-294(at)-294(its)-294(initial)-294(value.)-294(Plasma)]TJ 0 -1.122 TD [(sodium)-304(increased)-304(from)-304(142.0)-304(to)-304(145.2)-304(meq/l)-304(during)-304(4)-304(days)-304(of)]TJ T* [(high)-464(salt.)-464(Neither)-464(plasma)-464(volume,)-464(hematocrit,)-464(nor)-464(central)]TJ T* [(venous)-350(pressure)-350(changed)-350(signi\256cantly)-350(on)-350(the)-350(high-salt)-350(diet.)]TJ T* [(In)-206(contrast,)-206(the)-206(inbred)-206(Dahl)-206(salt-resistant)-206(rats)-206(\(SR/Jr\))-206(did)-206(not)]TJ T* [(increase)-285(their)-285(BP)-267(during)-285(body)-285(weight)-285(control)-285(when)-285(given)-285(4%)]TJ T* [(salt.)-533(This)-533(demonstrates)-533(that)-533(volume)-533(expansion)-533(is)-533(not)-533(an)]TJ T* [(obligatory)-334(step)-334(in)-334(the)-334(pressure)-334(response)-334(to)-334(increased)-334(salt)-334(in)]TJ T* [(SS/Jr)-466(rats.)-466(Our)-466(results)-466(obtained)-466(with)-466(oral)-466(presentation)-466(of)]TJ T* [(salt,)-517(in)-517(contrast)-517(to)-517(intravenous,)-517(represent)-517(a)-517(physiological)]TJ T* [(evaluation)-311(of)-311(the)-311(signi\256cance)-311(of)-311(volume)-311(changes)-311(in)-311(response)]TJ T* [(to)-324(dietary)-324(salt)-324(because)-324(no)-324(potential)-324(regulatory)-324(re\257exes)-324(have)]TJ T* [(been)-233(bypassed.)]TJ 0 -1.678 TD [(Dahl)-535(rats;)-535(genetic)-535(models;)-535(plasma)-535(volume;)-535(blood)-535(volume;)]TJ 0 -1.122 TD [(plasma)-233(sodium;)-233(extracellular)-233(\257uid)-233(volume)]TJ ET q 215.1773987 0 0 3 66.5290985 307.4909973 cm BI /W 897 /H 13 /BPC 1 /CS /G ID ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿþÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿðÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÀ?þ€À€€ÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿðÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ?èÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÀÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿù€ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿ€ EI Q BT /T1_0 1 Tf 7.441 0 0 7.441 48.569 280.766 Tm [(SALT)-389(IN)-389(THE)-389(DIET)]TJ 9.978 0 0 9.978 124.916 280.766 Tm [(appears)-290(to)-290(be)-290(of)-290(central)-290(importance)-290(to)]TJ -7.651 -1.11 Td [(the)-288(increase)-288(in)-288(blood)-288(pressure)-288(in)-288(most)-288(forms)-288(of)-288(human)]TJ 0 -1.11 TD [(and)-374(experimental)-374(hypertension.)-374(The)-374(exact)-374(connection)]TJ 0 -1.11 TD [(between)-305(increased)-305(salt)-305(and)-305(hypertension)-305(has)-305(yet)-305(to)-305(be)]TJ 0 -1.11 TD [(determined.)-383(A)-383(widely)-438(accepted)-438(model,)-438(originally)-438(con-)]TJ T* [(ceived)-210(by)-156(Arthur)-210(Guyton)-210(and)-210(Thomas)-210(Coleman)-210(\(13,)-210(14\),)]TJ T* [(postulates)-479(that)-479(volume)-479(expansion)-479(in)-479(response)-479(to)-479(in-)]TJ T* [(creased)-368(salt)-368(is)-368(an)-368(integral)-368(step)-368(in)-368(the)-368(development)-368(of)]TJ 0 -1.11 TD [(hypertension.)-545(The)-545(theoretical)-545(importance)-545(of)-545(volume)]TJ 0 -1.11 TD [(expansion)-483(is)-483(well)-484(founded)-483(and)-483(is)-483(an)-483(entirely)-483(logical)]TJ T* [(hypothesis)-233(given)-233(the)-233(presently)-233(available)-233(data.)]TJ 1 -1.11 Td [(A)-256(previous)-310(study)-310(by)-310(Greene)-310(et)-310(al.)-310(\(1)55(1\))-310(evaluated)-310(the)]TJ -1 -1.11 Td [(importance)-246(of)-246(salt)-246(versus)-246(volume)-246(in)-246(Dahl)-246(salt-sensitive)]TJ T* [(rats)-331(by)-331(control)-331(of)-331(body)-331(weight)-331(\(and)-331(thus)-331(\257uid)-331(volume\))]TJ T* [(via)-299(feedback)-299(control)-299(of)-299(the)-299(intravenous)-299(delivery)-299(of)-299(salt)]TJ 0 -1.11 TD [(and)-504(water)74(.)-504(These)-504(critical)-504(experiments)-504(demonstrated)]TJ 26.4 50.607 Td [(the)-241(potential)-241(importance)-241(of)-241(volume.)-241(That)-241(is,)-241(they)-241(found)]TJ 0 -1.1 TD [(that)-380(if)-380(body)-380(\257uid)-380(volume)-380(was)-380(not)-380(allowed)-380(to)-380(increase)]TJ T* [(during)-405(delivery)-405(of)-405(excess)-405(salt,)-405(the)-405(blood)-405(pressure)-405(did)]TJ T* [(not)-478(go)-478(up,)-478(despite)-478(hypernatremia.)-478(Nevertheless,)-478(the)]TJ T* [(full)-526(extent)-526(of)-526(all)-526(physiological)-526(interactions)-526(may)-526(not)]TJ T* [(have)-246(been)-246(revealed)-246(in)-246(these)-246(experiments,)-246(because)-246(body)]TJ T* [(weight)-397(was)-397(controlled)-397(by)-397(intravenous)-397(delivery)-397(of)-397(salt)]TJ T* [(and)-587(water)74(.)-587(This)-587(route)-587(of)-587(delivery)-587(bypasses)-587(several)]TJ T* [(important)-248(a)10(f)28(ferent)-248(re\257exes)-248(that)-248(are)-248(known)-248(to)-248(in\257uence)]TJ T* [(the)-259(renal)-259(handling)-259(of)-259(salt.)-259(The)-259(most)-259(important)-259(of)-259(these)]TJ T* [(`)18(`salt)-584(input)-584(re\257exes')18(')-529(has)-584(been)-584(demonstrated)-584(in)-584(the)]TJ T* [(intestine)-233(and)-233(the)-233(liver)-233(\(2,)-233(20)-56(\261)-56(24\).)]TJ 1 -1.1 Td [(W)37(ith)-365(this)-365(information)-365(in)-365(mind,)-365(we)-365(designed)-365(experi-)]TJ -1 -1.1 Td [(ments)-574(to)-574(again)-574(evaluate)-574(the)-574(importance)-574(of)-574(volume)]TJ T* [(expansion)-603(in)-603(salt-sensitive)-603(rats,)-603(only)-603(this)-603(time)-603(we)]TJ T* [(performed)-251(experiments)-251(at)-251(a)-251(higher)-251(level)-251(of)-251(integration.)]TJ T* [(That)-410(is,)-410(we)-410(controlled)-410(the)-410(rat')37(s)-410(body)-410(weight)-410(constant)]TJ 0 -1.1 TD [(while)-207(they)-207(were)-207(allowed)-207(to)-207(take)-207(in)-207(salt)-207(and)-207(water)-207(orally)111(.)]TJ T* [(Oral)-537(presentation)-537(of)-537(food)-537(and)-537(water)74(,)-537(in)-537(contrast)-537(to)]TJ T* [(intravascular)-404(delivery)111(,)-404(represents)-404(a)-404(more)-404(meaningful)]TJ T* [(evaluation)-244(of)-244(the)-244(physiological)-244(and)-244(pathological)-244(signi\256-)]TJ T* [(cance)-267(of)-267(volume)-267(changes)-267(in)-267(response)-267(to)-267(salt)-267(because)-267(no)]TJ T* [(potential)-522(regulatory)-522(steps)-522(have)-522(been)-522(bypassed.)-522(Our)]TJ T* [(data)-235(support)-235(the)-235(hypothesis)-235(that)-235(net)-235(volume)-235(expansion)]TJ T* [(is)-424(not)-424(an)-424(obligatory)-424(step)-424(in)-424(the)-424(pressure)-424(response)-424(to)]TJ T* [(increased)-463(salt)-463(and)-463(suggest)-463(that)-463(the)-463(concentration)-463(of)]TJ T* [(sodium)-233(in)-233(the)-233(plasma)-233(may)-233(play)-233(a)-233(critical)-233(role.)]TJ /T1_2 1 Tf 7.982 0 0 7.982 311.987 314.566 Tm (METHODS)Tj /T1_1 1 Tf 8.98 0 0 8.98 321.965 297.309 Tm [(Animal)-432(model)]TJ /T1_0 1 Tf 6.653 0 Td [(.)-432(Experiments)-432(were)-432(performed)-432(in)-432(male)-432(in-)]TJ 0.011 Tc -7.764 -1.111 Td [(bred)-676(Dahl)-676(salt-sensitive)-676(\(SS/Jr\))-676(and)-676(inbred)-676(Dahl)-676(salt-)]TJ 0 Tc 0 -1.111 TD [(resistant)-503(\(SR/Jr\))-503(strains)-503(of)-503(rats.)-503(These)-503(strains)-503(have)-503(been)]TJ T* [(selectively)-429(bred)-429(for)-429(their)-429(blood)-429(pressure)-429(response)-429(to)-429(a)-429(diet)]TJ T* [(high)-293(in)-293(sodium)-293(chloride)-293(\(salt\).)-293(The)-293(SS/Jr)-293(rats)-293(develop)-293(hyper)18(-)]TJ 0 -1.111 TD [(tension)-296(on)-296(a)-296(diet)-296(high)-296(in)-296(salt,)-296(whereas)-296(the)-296(SR/Jr)-296(do)-296(not.)-296(The)]TJ T* [(rats)-488(for)-488(this)-488(work)-488(were)-488(obtained)-488(from)-488(the)-488(colony)-488(of)-488(John)]TJ T* [(Rapp,)-406(which)-406(is)-406(maintained)-406(at)-406(the)-406(Medical)-406(ÃÛÌÒ´«Ã½)-406(of)-406(Ohio,)]TJ T* [(T)92(oledo,)-214(OH.)-214(Each)-214(of)-214(these)-214(strains)-214(has)-214(been)-214(bred)-214(for)-214(more)-214(than)]TJ T* [(70)-562(generations)-562(of)-562(brother)18(-sister)-562(matings.)-562(Thus)-562(measured)]TJ T* [(di)10(f)28(ferences)-507(for)-507(any)-507(given)-507(phenotypic)-507(trait)-507(within)-507(a)-507(strain)]TJ T* [(derive)-233(mainly)-233(from)-233(environmental)-233(in\257uences.)]TJ /T1_1 1 Tf 1.111 -1.111 Td [(Animal)-361(preparation.)]TJ /T1_0 1 Tf 9.867 0 Td [(All)-361(animals)-361(were)-361(weaned)-361(at)-361(4)-361(wk)-361(of)]TJ -10.978 -1.111 Td [(age)-350(and)-350(raised)-350(on)-350(low-salt)-350(chow)-350(\(0.2%)-350(NaCl\))-350(and)-350(tap)-350(water)]TJ T* [(until)-630(8)-630(wk)-630(old)-630(\(body)-630(wt)-630(300)]TJ /T1_3 1 Tf 15.299 0 Td (6)Tj /T1_0 1 Tf 1.463 0 Td [(20)-630(g\).)-630(Rats)-630(were)-630(then)]TJ -16.762 -1.111 Td [(anesthetized)-232(with)-232(a)-232(mixture)-232(of)-232(ketamine)-232(\(80)-232(mg/kg\),)-232(xylazine)]TJ T* [(\(12)-236(mg/kg\),)-236(and)-236(atropine)-236(\(0.032)-236(mg/kg\))-236(via)-236(an)-236(intraperitoneal)]TJ T* [(injection.)-358(MicroRenathane)-358(\(0.040)-358(OD)]TJ /T1_3 1 Tf 17.784 0 Td (3)Tj /T1_0 1 Tf 1.191 0 Td [(0.025)-358(ID\))-358(catheters)]TJ -18.974 -1.111 Td [(extended)-440(with)-440(T)52(ygon)-440(plastic)-440(tubing)-440(were)-440(inserted)-440(into)-440(the)]TJ T* [(right)-330(carotid)-330(artery)-330(and)-330(the)-330(right)-330(jugular)-330(vein)-330(for)-330(the)-330(direct)]TJ T* [(measurements)-329(of)-329(arterial)-329(pressure)-329(and)-329(central)-329(venous)-329(pres-)]TJ T* [(sure)-299(and)-299(for)-299(the)-299(collection)-299(of)-299(blood)-299(samples.)-299(The)-299(free)-299(ends)-299(of)]TJ T* [(the)-325(tubing)-325(were)-325(tunneled)-325(subcutaneously)-325(to)-325(exit)-325(the)-325(skin)-325(at)]TJ T* [(the)-248(midscapular)-248(region.)-193(Antibiotic)-248(ointment)-248(\(Bacitracin)-248(Zinc,)]TJ T* [(Neomycin)-243(Sulfate,)-243(and)-243(Polymyxin)-243(B)-243(Sulfate\))-243(was)-243(used)-243(on)-243(the)]TJ ET 0 0 0 1 K 0.499 w 10 M 0 j 0 J []0 d 48.569 94.382 m 300.013 94.382 l S BT /T1_0 1 Tf 7.982 0 0 7.982 56.551 84.688 Tm [(The)-263(costs)-263(of)-263(publication)-263(of)-263(this)-263(article)-263(were)-263(defrayed)-263(in)-263(part)-263(by)-263(the)]TJ -1 -1.125 Td [(payment)-566(of)-566(page)-566(charges.)-566(The)-566(article)-566(must)-566(therefore)-566(be)-566(hereby)]TJ 0 -1.125 TD [(marked)-369(`)18(`)]TJ /T1_1 1 Tf 4.314 0 Td (advertisement)Tj /T1_0 1 Tf 6.46 0 Td [(')18(')-314(in)-369(accordance)-369(with)-369(18)-369(U.S.C.)-369(Section)-369(1734)]TJ -10.775 -1.125 Td [(solely)-233(to)-233(indicate)-233(this)-233(fact.)]TJ 15.065 -2.25 Td [(0363-61)55(19/99)-366($5.00)-366(Copyright)]TJ /T1_4 1 Tf 9.578 0 0 9.578 283.319 37.395 Tm (r)Tj /T1_0 1 Tf 7.982 0 0 7.982 291.564 39.787 Tm [(1999)-366(the)-311(American)-366(Physiological)-366(Society)]TJ -30.442 0 Td (R1392)Tj ET 0 G 1 w /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_5 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_5 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_5 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 115 0 obj<> endobj 116 0 obj<> endobj 117 0 obj[115 0 R] endobj 118 0 obj<> endobj 122 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 8.98 0 0 8.98 48.569 721.519 Tm [(incisions)-210(after)-210(surgery)-210(to)-210(prevent)-210(infection)-210(and)-210(irritation.)-210(The)]TJ 0 -1.111 TD [(exteriorized)-505(tubing)-505(was)-505(routed)-505(out)-505(of)-505(the)-505(cage)-505(through)-505(a)]TJ T* [(stainless)-344(steel)-344(spring)-344(to)-344(protect)-344(the)-344(tubing.)-344(This)-344(spring)-344(was)]TJ T* [(attached)-236(to)-236(a)-236(lighter)-236(extension)-236(spring)-236(that)-236(allowed)-236(maximum)]TJ T* [(movement)-262(of)-262(the)-262(rat)-262(with)-262(a)-262(minimum)-262(tension)-262(on)-262(the)-262(springs.)]TJ 0 -1.111 TD [(The)-212(tubing)-212(exiting)-212(from)-212(the)-212(heavier)-212(spring)-212(was)-212(connected)-212(to)-212(a)]TJ T* [(\257uid)-235(delivery)-235(system)-235(that)-235(provided)-235(constant)-235(\257ow)-235(of)-235(a)-235(heparin)]TJ T* [(saline)-233(solution)-233(\(50)-233(U/ml\).)]TJ 1.111 -1.111 Td [(A)-164(\257uid)-219(delivery)-219(system)-219(was)-219(connected)-219(to)-219(each)-219(catheter)74(.)-219(The)]TJ -1.111 -1.111 Td [(\257uid)-269(delivery)-269(system)-269(was)-269(made)-269(from)-269(a)-269(rubber)-269(bulb,)-269(a)-269(0.2-m)]TJ T* [(\256lter)74(,)-330(and)-330(a)-330(hydraulic)-330(resistor)-330(\(Fig.)-330(1\).)-330(The)-330(rubber)-330(bulb)-330(was)]TJ T* [(connected)-312(in)-312(series)-312(with)-312(the)-312(\256lter)-312(and)-312(the)-312(hydraulic)-312(resistor)]TJ T* [(for)-201(the)-201(continuous)-201(delivery)-201(of)-201(saline)-201(to)-201(each)-201(catheter)74(.)-201(The)-201(bulb)]TJ T* [(has)-350(a)-350(transmural)-350(pressure)-350(of)]TJ /T1_1 1 Tf 14.047 0 Td (,)Tj /T1_0 1 Tf 0.833 0 Td [(500)-350(mmHg)-350(when)-350(\256lled)-350(with)]TJ -14.88 -1.111 Td [(8)-295(ml)-295(of)-295(saline)-295(and)-295(drives)-295(\257uid)-295(through)-295(the)-295(\256lter)-295(and)-295(resistor)]TJ 0 -1.111 TD [(without)-266(any)-266(appreciable)-266(decline)-266(in)-266(bulb)-266(pressure)-266(with)-266(a)-266(\257uid)]TJ 0 -1.111 TD [(loss)-349(of)-349(up)-349(to)-349(4)-349(ml.)-349(The)-349(resistor)-349(was)-349(made)-349(from)-349(glass)-349(tubing)]TJ T* [(\(25)-472(m)-472(ID\))-473(that)-473(was)-473(\256xed)-472(within)-472(a)-472(21-gauge)-472(needle)-472(with)]TJ T* [(Silastic)-332(glue.)-332(The)-332(length)-332(of)-332(the)-332(glass)-332(tubing)-332(was)-332(3.2)-332(cm)-332(and)]TJ T* [(resulted)-234(in)-234(a)-234(delivery)-234(of)]TJ /T1_1 1 Tf 11.005 0 Td (,)Tj /T1_0 1 Tf 0.833 0 Td [(1)-234(ml/day)-234(for)-235(the)-234(arterial)-235(tubing)-234(and)]TJ -11.838 -1.111 Td [(1.5)-338(ml/day)-338(for)-338(the)-338(venous)-338(tubing.)-338(This)-338(\257uid)-338(delivery)-338(system)]TJ T* [(enabled)-363(us)-363(to)-363(keep)-363(both)-363(catheters)-363(patent)-363(for)-363(extended)-363(peri-)]TJ T* (ods.)Tj 1.111 -1.111 Td [(The)-254(\257uid)-254(delivery)-254(system)-254(was)-254(connected)-254(to)-254(the)-254(light)-254(tether)]TJ -1.111 -1.111 Td [(spring)-375(from)-375(below)-375(and)-375(to)-375(a)-375(360\311)-375(swivel)-375(that)-375(connected)-375(to)-375(a)]TJ T* [(support)-379(arm)-379(above)-379(the)-379(cage.)-379(The)-379(entire)-379(tethering)-379(and)-379(\257uid)]TJ T* [(system)-476(rotated)-476(freely)-476(and)-476(allowed)-476(essentially)-476(unrestricted)]TJ T* [(movement)-233(of)-233(the)-233(rat.)]TJ /T1_2 1 Tf 1.111 -1.111 Td [(Control)-451(of)-451(body)-451(weight.)]TJ /T1_0 1 Tf 11.597 0 Td [(A)-396(servo-control)-451(feedback)-451(system)]TJ -12.708 -1.111 Td [(was)-253(designed)-253(that)-253(controlled)-253(body)-253(weight)-253(constant)-253(while)-253(still)]TJ T* [(allowing)-482(rats)-482(to)-482(take)-482(on)-482(food)-482(and)-482(water)-482(orally)-482(\(Fig.)-482(1\).)-427(A)]TJ T* [(modi\256ed)-396(metabolic)-396(cage)-396(was)-396(mounted)-396(on)-396(an)-396(electronic)-396(bal-)]TJ T* [(ance)-378(\(Sartorius)-378(BP)-360(6100\))-378(by)-378(which)-378(the)-378(total)-378(weight)-378(of)-378(cage)]TJ T* [(and)-568(rat,)-568(including)-568(tether)-568(and)-568(\257uid)-568(delivery)-568(system,)-568(was)]TJ T* [(measured.)-572(The)-572(waste)-572(tray)111(,)-572(water)-572(delivery)-572(line,)-572(and)-572(food)]TJ T* [(holder)-413(were)-413(all)-413(supported)-413(outside)-413(of)-413(the)-413(cage)-413(so)-413(that)-413(their)]TJ T* [(weight)-357(did)-357(not)-357(bear)-357(on)-357(the)-357(balance.)-357(When)-357(the)-357(rat)-357(had)-357(been)]TJ 29.333 40 Td [(transferred)-343(into)-343(the)-343(cage)-343(for)-343(the)-343(start)-343(of)-343(weight)-343(control,)-343(the)]TJ 0 -1.122 TD [(balance)-234(was)-234(tared)-234(to)-234(zero.)-234(The)-234(digital)-234(signal)-234(from)-234(the)-234(balance)]TJ T* [(was)-221(fed)-221(to)-221(an)-221(80386)-221(microcomputer)-221(as)-221(the)-221(input)-221(signal)-221(for)-221(the)]TJ 0 -1.122 TD [(servo-control)-215(algorithm)-215(that)-215(was)-215(written)-215(using)-215(Labtech)-215(Note-)]TJ 0 -1.122 TD [(book)-371(software.)-371(The)-371(computer)-371(was)-371(connected)-371(to)-371(a)-371(peristaltic)]TJ T* [(pump)-374(\(Harvard)-319(Apparatus,)-374(model)-374(1201\).)-374(When)-374(the)-374(balance)]TJ T* [(detected)-497(a)-497(decrease)-497(o)]TJ 0.497 Tc 10.397 0 Td [(f1go)497(r)]TJ 0 Tc 4.357 0 Td [(more)-497(\(because)-497(of)-497(urination,)]TJ -14.754 -1.122 Td [(defecation,)-392(and)-392(insensible)-392(loss)-392(of)-392(water\),)-392(the)-392(algorithm)-392(put)]TJ 0 -1.122 TD [(out)-337(an)-337(error)-337(signal)-337(to)-337(a)-337(digital-to-analog)-337(\(D/A\))-337(channel)-337(on)-337(a)]TJ T* [(Data)-303(T)62(ranslation)-303(signal)-303(board)-303(\(DT2801\).)-303(This)-303(analog)-303(output)]TJ T* [(activated)-210(the)-210(water)-210(pump)-210(that)-210(delivered)-210(water)-210(to)-210(a)-210(pan)-210(inside)]TJ T* [(the)-546(cage.)-546(Once)-546(enough)-546(water)-546(was)-546(delivered)-546(to)-546(bring)-546(the)]TJ T* [(balance)-523(back)-523(to)-523(zero,)-523(the)-523(pump)-523(automatically)-523(turned)-523(o)10(f)28(f.)]TJ T* [(Therefore,)-276(the)-276(weight)-276(of)-276(the)-276(rat)-276(was)-276(kept)-276(at)-276(a)-276(constant)-276(value)]TJ T* [(through)-404(this)-404(feedback)-404(control)-404(of)-404(its)-404(water)-404(supply)111(,)-404(although)]TJ 0 -1.122 TD [(the)-437(rat)-437(constantly)-437(had)-437(free)-437(access)-437(to)-437(food)-437(and)-437(water)74(.)-437(Rats)]TJ 0 -1.122 TD [(promptly)-253(drank)-253(essentially)-253(all)-253(of)-253(the)-253(water)-253(delivered)-253(into)-253(the)]TJ T* [(pan)-304(with)-304(little)-304(or)-304(no)-304(spillage.)-304(Because)-304(rats)-304(would)-304(grasp)-304(onto)]TJ T* [(the)-324(food)-324(holder)-324(for)-324(up)-324(to)-324(2)-324(min)-324(while)-324(they)-324(were)-324(eating,)-324(thus)]TJ T* [(reducing)-307(the)-307(weight)-307(bearing)-307(on)-307(the)-307(balance)-307(by)-307(10)-307(g)-307(or)-307(more,)]TJ T* [(the)-412(output)-412(signal)-412(from)-412(the)-412(computer)-412(was)-412(set)-412(with)-412(a)-412(5-min)]TJ T* [(delay)111(.)-276(That)-276(is,)-276(only)-276(a)-276(decline)-276(in)-276(weight)-276(of)]TJ /T1_3 1 Tf 19.083 0 Td ($)Tj /T1_0 1 Tf 0.833 0 Td [(1)-276(g)-276(that)-276(persisted)]TJ -19.915 -1.122 Td [(for)-537(5)-537(min)-537(caused)-537(the)-537(pump)-537(to)-537(deliver)-537(water)-537(to)-537(the)-537(rat')37(s)]TJ T* [(drinking)-254(pan.)-254(This)-254(delay)-254(avoided)-254(the)-254(errors)-254(in)-254(water)-254(delivery)]TJ T* [(that)-420(would)-420(have)-420(resulted)-420(from)-420(balance)-420(changes)-420(due)-420(to)-420(the)]TJ T* [(normal)-233(activity)-233(of)-233(the)-233(rats.)]TJ /T1_2 1 Tf 1.111 -1.122 Td [(Experimental)-380(measurements.)]TJ /T1_0 1 Tf 13.847 0 Td [(Arterial)-380(and)-380(central)-380(venous)]TJ -14.958 -1.122 Td [(pressures)-384(were)-384(measured)-384(simultaneously)-384(from)-384(the)-384(indwell-)]TJ T* [(ing)-458(catheters)-458(in)-458(the)-458(carotid)-458(artery)-458(and)-458(jugular)-458(vein)-458(using)]TJ T* [(Statham)-294(strain)-294(gauge)-294(transducers)-294(\(P23Db\))-294(that)-294(were)-294(placed)]TJ T* [(at)-228(heart)-228(level)-228(of)-228(the)-228(rat.)-228(Each)-228(transducer)-228(was)-228(calibrated)-228(daily)]TJ T* [(with)-422(a)-422(water)-422(manometer)-422(before)-422(the)-422(study)111(.)-367(At)-422(least)-422(30-min)]TJ T* [(recordings)-273(of)-273(both)-273(pressures)-273(were)-273(performed)-273(at)-273(noon)-273(on)-273(each)]TJ T* [(day)-208(when)-208(the)-208(rats)-208(were)-208(quiescent,)-208(and)-208(the)-208(most)-208(stable)-208(10-min)]TJ T* [(segment)-225(was)-225(extracted)-225(for)-225(analysis.)-225(The)-225(raw)-225(pressure)-225(signals)]TJ T* [(\(voltages\))-199(were)-199(ampli\256ed)-199(on)-199(a)-199(Sensormedics)-199(R-61)55(1)-199(polygraph,)]TJ T* [(sampled)-306(at)-306(300)-306(Hz)-306(and)-306(then)-306(digitized)-306(by)-306(a)-306(Data)-306(T)62(ranslation)]TJ T* [(A/D)-222(board)-222(\(DT)-222(2801\).)-223(The)-222(digital)-223(signals)-223(were)-222(averaged)-222(every)]TJ T* [(second)-360(and)-360(stored)-360(on)-360(the)-360(hard)-360(drive)-360(of)-360(an)-360(80386)-360(microcom-)]TJ T* [(puter)74(.)-243(The)-243(daily)-243(pressure)-243(was)-243(obtained)-243(by)-243(taking)-243(the)-243(average)]TJ T* [(of)-233(the)-233(10-min)-233(segment.)]TJ 1.111 -1.122 Td [(Plasma)-535(volume)-535(was)-535(estimated)-535(from)-535(the)-535(distribution)-535(of)]TJ -1.111 -1.122 Td [(intravenously)-251(administered)-251(Evans)-251(blue)-251(solution.)-251(The)-251(plasma)]TJ T* [(concentration)-276(of)-276(Evans)-276(blue)-276(was)-276(measured)-276(spectrophotomet-)]TJ T* [(rically)-270(\(Gilford,)-271(Response)-270(II\))-270(from)-270(a)-270(0.2-ml)-270(sample)-270(of)-270(arterial)]TJ T* [(blood)-359(withdrawn)-359(5)-359(min)-359(after)-359(the)-359(injection)-359(of)-359(0.2)-359(ml)-359(of)-359(0.1%)]TJ T* [(Evans)-316(blue)-316(solution,)-316(as)-316(described)-316(by)-316(Belcher)-316(and)-316(Harris)-316(\(1\).)]TJ T* [(The)-231(plasma)-231(volume)-231(was)-231(calculated)-231(from)-231(the)-231(amount)-231(of)-231(Evans)]TJ T* [(blue)-233(injected)-233(divided)-233(by)-233(its)-233(plasma)-233(concentration.)]TJ 1.111 -1.122 Td [(The)-223(hematocrit)-223(and)-223(the)-223(concentrations)-223(of)-223(Na)]TJ /T1_3 1 Tf 5.987 0 0 5.987 504.915 230.482 Tm (1)Tj /T1_0 1 Tf 8.98 0 0 8.98 511.904 227.738 Tm [(and)-223(K)]TJ /T1_3 1 Tf 5.987 0 0 5.987 536.524 230.482 Tm (1)Tj /T1_0 1 Tf 8.98 0 0 8.98 543.513 227.738 Tm (were)Tj -25.782 -1.122 Td [(measured)-362(from)-362(a)-362(0.25-ml)-362(sample)-362(of)-362(arterial)-362(blood.)-362(Approxi-)]TJ 0 -1.122 TD [(mately)-365(0.05)-365(ml)-365(of)-365(blood)-365(was)-365(drawn)-365(into)-365(four)-365(microcapillary)]TJ 0 -1.122 TD [(tubes)-557(and)-557(spun)-557(on)-557(a)-557(Fisher)-557(Micro-Hematocrit)-557(centrifuge)]TJ 0 -1.111 TD [(\(model)-528(335\))-528(for)-528(3)-528(min;)-528(the)-528(four)-528(values)-528(were)-528(averaged)-528(to)]TJ T* [(estimate)-330(the)-330(hematocrit.)-330(The)-330(remaining)-330(0.2)-329(ml)-330(of)-330(blood)-329(was)]TJ T* [(centrifuged)-312(in)-312(an)-312(IEC)-312(MicroMax)-312(centrifuge)-312(at)-312(3,000)-312(rpm)-311(for)]TJ T* [(3)-236(min,)-236(and)-236(0.1)-236(ml)-236(of)-236(plasma)-236(was)-236(separated)-236(for)-236(the)-236(determina-)]TJ T* [(tion)-467(of)-467(Na)]TJ /T1_3 1 Tf 5.987 0 0 5.987 356.46 150.361 Tm (1)Tj /T1_0 1 Tf 8.98 0 0 8.98 365.64 147.617 Tm [(and)-467(K)]TJ /T1_3 1 Tf 5.987 0 0 5.987 392.452 150.361 Tm (1)Tj /T1_0 1 Tf 8.98 0 0 8.98 401.632 147.617 Tm [(concentrations)-467(with)-467(an)-467(IL)-449(943)-467(Flame)]TJ -9.983 -1.111 Td [(Photometer)74(.)]TJ 1.111 -1.111 Td [(Salt)-399(consumption)-399(was)-399(estimated)-399(from)-399(the)-399(product)-399(of)-399(the)]TJ -1.111 -1.111 Td [(mass)-383(of)-383(food)-383(eaten)-383(and)-383(the)-383(fractional)-383(content)-383(of)-383(salt)-383(in)-383(the)]TJ 0 -1.111 TD [(chow)92(.)-234(Food)-234(consumption)-234(was)-234(estimated)-234(by)-234(weighing)-234(the)-234(daily)]TJ 0 -1.111 TD [(changes)-654(in)-654(the)-654(amount)-654(of)-654(food)-654(in)-654(the)-654(food)-654(holder)-654(and)]TJ T* [(subtracting)-223(the)-223(food)-223(debris)-223(in)-223(the)-223(waste)-223(tray)111(.)-223(W)74(ater)-223(consump-)]TJ T* [(tion)-295(was)-295(recorded)-295(from)-295(the)-295(daily)-295(changes)-295(in)-295(volume)-295(of)-295(water)]TJ T* [(in)-401(the)-401(syringe)-401(that)-401(served)-401(as)-401(a)-401(reservoir)-401(for)-401(the)-401(peristaltic)]TJ T* (pump.)Tj ET q 252 0 0 196 48.5688019 150.3665924 cm /Im0 Do Q BT /T1_0 1 Tf 7.982 0 0 7.982 48.569 138.569 Tm [(Fig.)-234(1.)-556(Feedback)-234(control)-234(of)-234(body)-234(weight.)-234(T)92(otal)-234(weight)-234(of)-234(cage)-234(and)-234(rat,)]TJ 0 -1.125 TD [(including)-517(tether)-517(and)-517(\257uid)-517(delivery)-517(system,)-517(was)-517(measured)-517(by)-517(an)]TJ T* [(electronic)-461(balance)-461(while)-461(waste)-461(tray)111(,)-461(water)-461(delivery)-461(line,)-461(and)-461(food)]TJ T* [(holder)-386(were)-386(supported)-386(outside)-386(of)-386(balance)-386(system.)-386(Changes)-386(of)-386(body)]TJ T* [(weight)-574(were)-574(detected)-574(and)-574(set)-574(within)-574(range)-574(from)-574(0)-574(to)]TJ /T1_3 1 Tf 27.333 0 Td (2)Tj /T1_0 1 Tf 0.574 Tc 0.833 0 Td [(1gb)574(y)]TJ 0 Tc -28.166 -1.125 Td [(computer)-451(that)-451(was)-451(connected)-451(to)-451(a)-451(perstaltic)-451(water)-451(pump,)-451(so)-451(that)]TJ T* [(pump)-369(was)-369(turned)-369(on)-369(and)-369(o)10(f)28(f)-369(when)-369(changes)-369(of)-369(weight)-369(exceeded)-369(low)]TJ T* [(and)-406(high)-406(limits.)-406(Thus)-406(input)-406(\(food)-406(and)-406(water\))-406(was)-406(always)-406(equal)-406(to)]TJ T* [(output)-561(\(urination,)-561(defecation,)-561(and)-561(insensible)-561(loss)-561(of)-561(water\),)-561(and)]TJ T* [(weight)-233(of)-233(rat)-233(was)-233(kept)-233(constant.)]TJ 9.978 0 0 9.978 534.05 744.772 Tm (R1393)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w 10 M 0 j 0 J []0 d /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 123 0 obj<> endobj 124 0 obj<> endobj 125 0 obj[123 0 R] endobj 126 0 obj<> endobj 130 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 8.98 0 0 8.98 58.547 721.519 Tm [(Experimental)-231(protocols)]TJ /T1_1 1 Tf 10.541 0 Td [(.)-231(Five)-231(groups)-231(of)-231(rats)-231(were)-231(chosen)-231(for)]TJ -11.652 -1.111 Td [(study)-300(on)-300(the)-300(basis)-300(of)-300(strain,)-300(salt)-300(diet,)-300(and)-300(control)-300(or)-300(noncon-)]TJ 0 -1.111 TD [(trol)-371(of)-371(body)-371(weight.)-371(For)-371(SS/Jr)-371(rats,)-371(there)-371(were)-371(four)-371(groups:)]TJ T* [(SS/Jr)-204(rats)-204(on)-204(0.2%)-204(NaCl)-204(chow)92(,)-204(body)-204(weight)-204(not)-204(controlled,)]TJ /T1_0 1 Tf 26.355 0 Td (n)Tj /T1_2 1 Tf 0.815 0 Td (5)Tj /T1_1 1 Tf -27.17 -1.111 Td [(7;)-357(SS/Jr)-357(on)-357(0.2%)-357(NaCl)-357(chow)92(,)-357(body)-357(weight)-357(controlled,)]TJ /T1_0 1 Tf 25.012 0 Td (n)Tj /T1_2 1 Tf 0.968 0 Td (5)Tj /T1_1 1 Tf 1.19 0 Td (8;)Tj -27.169 -1.111 Td [(SS/Jr)-350(on)-350(4%)-350(NaCl)-350(chow)92(,)-350(body)-350(weight)-350(controlled,)]TJ /T1_0 1 Tf 22.934 0 Td (n)Tj /T1_2 1 Tf 0.961 0 Td (5)Tj /T1_1 1 Tf 1.183 0 Td [(7;)-350(and)]TJ -25.078 -1.111 Td [(SS/Jr)-207(on)-207(4%)-207(NaCl,)-207(body)-207(weight)-207(not)-207(controlled,)]TJ /T1_0 1 Tf 21.046 0 Td (n)Tj /T1_2 1 Tf 0.818 0 Td (5)Tj /T1_1 1 Tf 1.04 0 Td [(6.)-207(Only)-207(one)]TJ -22.904 -1.111 Td [(group)-326(of)-326(SR/Jr)-326(rats)-326(was)-326(studied,)-326(SR/Jr)-326(given)-326(4%)-326(NaCl)-326(chow)]TJ 0 -1.111 TD [(while)-243(body)-243(weight)-243(was)-243(controlled)-243(at)-243(zero)-243(change)-243(\()]TJ /T1_0 1 Tf 22.61 0 Td (n)Tj /T1_2 1 Tf 0.854 0 Td (5)Tj /T1_1 1 Tf 1.076 0 Td [(6\).)-243(This)]TJ -24.54 -1.111 Td [(is)-217(the)-217(only)-217(group)-216(that)-217(would)-216(provide)-217(new)-216(information)-216(because)]TJ T* [(numerous)-353(studies)-353(have)-353(already)-353(shown)-353(that)-353(SR/Jr)-353(are)-353(resis-)]TJ T* [(tant)-233(to)-233(salt-induced)-233(increases)-233(in)-233(blood)-233(pressure)-233(\(26\).)]TJ 1.111 -1.111 Td [(Seven)-430(days)-430(after)-430(surgery)-430(for)-430(instrumentation,)-430(rats)-430(were)]TJ -0.003 Tc -1.111 -1.111 Td [(transferred)-196(into)-196(the)-196(modi\256ed)-196(metabolic)-196(cages)-196(described)-196(above.)]TJ 0 Tc T* [(Then)-216(4)-216(days)-216(were)-216(allowed)-216(for)-216(them)-216(to)-216(adapt)-216(to)-216(the)-216(experimen-)]TJ 0 -1.111 TD [(tal)-440(environment)-440(while)-440(ingesting)-440(the)-440(low-salt)-440(chow)92(.)-440(During)]TJ 0 -1.111 TD [(this)-318(period,)-318(control)-318(measurements)-318(were)-318(performed)-318(to)-318(obtain)]TJ T* [(the)-225(baseline)-225(data)-225(of)-225(hemodynamic)-225(variables.)-170(After)-225(the)-225(control)]TJ T* [(period,)-227(rats)-227(were)-227(randomly)-227(chosen)-227(to)-227(have)-227(body)-227(weight)-227(either)]TJ T* [(controlled)-409(or)-409(not)-409(controlled)-409(while)-409(receiving)-409(food)-409(containing)]TJ T* [(either)-423(low)-423(salt)-423(\(0.2%)-423(NaCl\))-423(or)-423(high)-423(salt)-423(\(4%)-423(NaCl\))-423(for)-423(the)]TJ T* [(subsequent)-656(4)-656(days)-656(of)-656(study)111(.)-656(Body)-656(weight)-656(was)-656(recorded)]TJ T* [(continuously)-258(throughout)-258(the)-258(experiments)-258(in)-258(all)-258(rats.)-203(Arterial)]TJ T* [(and)-655(central)-655(venous)-655(blood)-655(pressures,)-655(hematocrit,)-655(plasma)]TJ T* [(sodium)-435(and)-435(potassium)-435(concentrations,)-435(and)-435(food)-435(and)-435(water)]TJ T* [(consumption)-358(were)-358(measured)-358(every)-358(day)111(.)-358(The)-358(plasma)-358(volume)]TJ T* [(was)-385(measured)-385(every)-385(fourth)-385(day)-385(to)-385(minimize)-385(blood)-385(loss)-385(and)]TJ T* (because)Tj /T1_3 1 Tf 3.911 0 Td (,)Tj /T1_1 1 Tf 0.833 0 Td [(48)-56(\261)-56(72)-281(h)-281(are)-281(needed)-281(for)-281(the)-281(rat)-281(to)-281(clear)-281(Evans)-281(blue)]TJ -4.744 -1.111 Td [(solution)-353(from)-353(its)-354(blood.)-299(A)-299(maximum)-353(of)-354(0.65)-353(ml)-354(of)-354(blood)-353(was)]TJ 0 -1.111 TD [(withdrawn)-231(for)-231(the)-231(measurement)-231(of)-231(plasma)-231(volume)-231(\(including)]TJ 0 -1.111 TD [(0.2)-276(ml)-276(for)-276(control)-276(reading)-276(before)-276(the)-276(injection)-276(of)-276(Evans)-276(blue\),)]TJ T* [(hematocrit,)-485(and)-485(plasma)-485(sodium)-485(and)-485(potassium)-485(concentra-)]TJ T* [(tions)-566(on)-566(the)-566(same)-566(day)111(.)-566(This)-566(amount)-566(of)-566(blood)-566(represents)]TJ T* [(2.5)-56(\261)-56(3.0%)-382(of)-382(the)-382(estimated)-382(total)-382(blood)-382(volume.)-382(The)-382(erythro-)]TJ T* [(cytes)-471(from)-471(the)-471(blood)-471(sample)-471(were)-471(resuspended)-471(in)-471(isotonic)]TJ T* [(saline)-233(and)-233(given)-233(back)-233(to)-233(the)-233(animal.)]TJ /T1_0 1 Tf 1.111 -1.111 Td [(Statistical)-290(analysis.)]TJ /T1_1 1 Tf 9.429 0 Td [(Data)-290(are)-290(presented)-290(as)-290(mean)-290(values)]TJ /T1_2 1 Tf 16.632 0 Td (6)Tj /T1_1 1 Tf -27.173 -1.111 Td [(SE.)-212(Mean)-212(arterial)-212(pressure)-212(and)-212(plasma)-212(sodium)-212(concentration)]TJ T* [(were)-436(compared)-436(with)-436(the)-436(average)-436(of)-436(their)-436(control)-436(measure-)]TJ T* [(ments)-211(within)-211(the)-211(group.)-211(The)-211(signi\256cance)-211(of)-211(di)10(f)28(ferences)-211(within)]TJ 0.016 Tc T* [(and)-680(between)-680(each)-680(group)-680(were)-680(evaluated)-680(by)-680(repeated-)]TJ 0 Tc T* [(measures)-387(ANOV)111(A)-387(followed)-442(by)-442(Student-Newman-Keuls)-442(test)]TJ T* [(for)-274(multiple)-274(comparison)-274(with)-274(a)-274(signi\256cance)-274(level)-274(of)-274(0.05.)-274(The)]TJ T* [(relationship)-568(between)-568(mean)-568(arterial)-568(pressure)-568(and)-568(plasma)]TJ T* [(sodium)-566(concentration)-566(was)-566(evaluated)-566(by)-566(linear)-566(regression)]TJ T* (analysis.)Tj /T1_4 1 Tf 7.982 0 0 7.982 48.569 254.846 Tm [(RESUL)55(TS)]TJ /T1_1 1 Tf 9.978 0 0 9.978 58.547 236.894 Tm [(The)-204(control)-204(measurements)-204(of)-204(mean)-204(arterial)-204(pressure,)]TJ -1 -1.1 Td [(plasma)-429(sodium)-429(concentration,)-429(body)-429(weight)-429(gain,)-429(and)]TJ 0 -1.1 TD [(salt)-283(and)-283(water)-283(intake)-283(for)-283(all)-283(\256ve)-283(groups)-283(of)-283(animals)-283(are)]TJ 26.4 50.7 Td [(summarized)-506(in)-506(T)62(able)-506(1.)-506(These)-506(values)-506(represent)-506(the)]TJ 0 -1.11 TD [(average)-304(of)-304(the)-304(4)-304(days)-304(of)-304(control)-304(on)-304(low)-304(salt)-304(\(individual)]TJ T* [(daily)-220(values)-220(for)-220(these)-220(variables)-220(are)-220(represented)-220(in)-220(Figs.)]TJ 0.056 Tc T* [(2\2616)-175(a)56(s)]TJ /T1_0 1 Tf 0 Tc 3.261 0 Td (days)Tj /T1_2 1 Tf 2.36 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (3)Tj /T1_1 1 Tf 0.787 0 Td (through)Tj /T1_0 1 Tf 3.934 0 Td [(day)-231(0)]TJ /T1_1 1 Tf 2.528 0 Td [(\).)-231(The)-231(blood)-231(pressures)-231(for)]TJ -13.703 -1.11 Td [(all)-261(the)-261(salt-sensitive)-261(\(S\))-261(groups)-261(of)-261(rats)-261(were)-261(not)-261(signi\256-)]TJ T* [(cantly)-303(di)10(f)28(ferent)-303(from)-303(each)-303(other)74(.)-303(The)-303(blood)-303(pressure)-303(of)]TJ T* [(the)-484(salt-resistant)-484(\(R\))-484(rats)-484(was)-484(on)-484(average,)-484(however)74(,)]TJ /T1_3 1 Tf T* (,)Tj /T1_1 1 Tf 0.833 0 Td [(25)-544(mmHg)-544(lower)-544(than)-544(the)-544(S)-544(rats.)-544(Plasma)-544(sodium)]TJ -0.833 -1.11 Td [(concentration)-360(was)-360(signi\256cantly)-360(elevated)-360(in)-360(the)-360(R)-360(rats)]TJ T* [(compared)-444(with)-444(all)-444(other)-444(groups.)-444(The)-444(S)-444(rats)-444(on)-444(0.2%)]TJ T* [(NaCl)-251(\()]TJ /T1_2 1 Tf 2.992 0 Td (1)Tj /T1_1 1 Tf 1.084 0 Td [(body)-251(weight)-251(control\))-251(and)-251(the)-251(R)-251(rats)-251(ate)-251(a)-251(little)]TJ -4.076 -1.1 Td [(less)-553(salt)-553(than)-553(the)-553(other)-553(groups)-553(during)-553(the)-553(control.)]TJ -0.001 Tc 0 -1.1 TD [(There)-198(were)-198(no)-198(signi\256cant)-198(di)10(f)27(ferences)-198(in)-198(water)-198(consump-)]TJ 0 Tc T* [(tion)-214(or)-214(body)-214(weight)-214(gain)-214(between)-214(the)-214(\256ve)-214(groups)-214(during)]TJ T* [(the)-233(4)-233(control)-233(days.)]TJ /T1_0 1 Tf 1 -1.1 Td [(SS/Jr)-482(rats)-482(on)-482(high-salt)-482(diet,)-482(without)-482(body)-482(weight)]TJ -1 -1.1 Td (control)Tj /T1_1 1 Tf 3.184 0 Td [(.)-447(As)-502(shown)-502(in)-502(Fig.)-502(2,)-502(mean)-502(arterial)-502(pressure)]TJ -3.184 -1.1 Td [(increased)-226(from)-226(an)-226(average)-226(of)-226(125.0)]TJ /T1_2 1 Tf 16.061 0 Td (6)Tj /T1_1 1 Tf 1.059 0 Td [(4.8)-226(mmHg)-226(during)]TJ -17.12 -1.1 Td [(the)-239(4)-239(control)-239(days)-239(to)-239(139.8)]TJ /T1_2 1 Tf 12.215 0 Td (6)Tj /T1_1 1 Tf 1.072 0 Td [(3.9)-239(mmHg)-239(on)-239(the)-239(\256rst)-239(day)]TJ -13.287 -1.1 Td [(of)-320(the)-320(high-salt)-320(diet.)-320(This)-320(pressure)-320(increase)-320(continued)]TJ T* [(and)-347(reached)-347(a)-347(peak)-347(of)-347(155.4)]TJ /T1_2 1 Tf 13.565 0 Td (6)Tj /T1_1 1 Tf 1.18 0 Td [(4.0)-347(mmHg)-347(on)]TJ /T1_0 1 Tf 6.689 0 Td [(day)-347(4)]TJ /T1_1 1 Tf 2.935 0 Td (of)Tj -24.368 -1.1 Td [(high-salt)-290(chow)92(.)-235(All)-290(the)-290(pressures)-290(during)-290(4)-290(days)-290(of)-290(high)]TJ T* [(salt)-275(were)-275(signi\256cantly)-275(higher)-275(than)-275(their)-275(control)-275(values)]TJ T* [(on)-220(low)-220(salt,)-220(and)-220(the)-220(change)-220(in)-220(pressure)-220(from)-220(the)-220(control)]TJ T* (to)Tj /T1_0 1 Tf 1.211 0 Td [(day)-322(4)]TJ /T1_1 1 Tf 2.885 0 Td [(of)-322(the)-322(high-salt)-322(diet)-322(was)-322(30.4)-322(mmHg.)-322(Plasma)]TJ -4.096 -1.1 Td [(sodium)-214(concentration)-214(also)-214(increased)-214(from)-214(an)-214(average)-214(of)]TJ T* (142.3)Tj /T1_2 1 Tf 2.702 0 Td (6)Tj /T1_1 1 Tf 1.033 0 Td [(0.2)-200(meq/l)-200(during)-200(4)-200(days)-200(of)-200(the)-200(control)-200(to)-200(143.8)]TJ /T1_2 1 Tf 20.635 0 Td (6)Tj /T1_1 1 Tf -24.37 -1.1 Td [(0.6)-433(meq/l)-433(on)-433(the)-433(\256rst)-433(day)-433(of)-433(high)-433(salt)-433(and)-433(remained)]TJ T* [(elevated)-387(for)-387(the)-387(next)-387(3)-387(days.)-387(Changing)-387(the)-387(food)-387(from)]TJ T* [(low)-382(salt)-382(to)-382(high)-382(salt)-382(caused)-382(an)-382(approximate)-382(18.7-fold)]TJ 0 -1.1 TD [(increase)-546(in)-546(daily)-546(salt)-546(intake.)-546(W)74(ater)-546(intake)-546(was)-546(in-)]TJ T* [(creased)-526(from)-526(the)-526(average)-526(of)-526(24.8)-526(to)-526(67.6)-526(ml/day)-526(in)]TJ T* [(response)-238(to)-238(the)-238(increased)-238(salt)-238(intake.)-238(Body)-238(weight)-238(gain)]TJ T* [(continued)-203(on)-203(a)-203(daily)-203(basis,)-203(however)74(,)-203(without)-203(di)10(f)28(ferences)]TJ T* [(between)-233(low)-233(salt)-233(and)-233(high)-233(salt.)]TJ /T1_0 1 Tf 1 -1.1 Td [(SS/Jr)-369(rats)-369(on)-369(high-salt)-369(diet,)-369(with)-369(body)-369(weight)-369(con-)]TJ -1 -1.1 Td (trol)Tj /T1_1 1 Tf 1.629 0 Td [(.)-217(For)-217(this)-217(group,)-217(control)-217(of)-217(body)-217(weight)-217(at)-217(a)-217(constant)]TJ -1.629 -1.1 Td [(value)-210(was)-210(started)-210(at)-210(the)-210(same)-210(time)-210(\()]TJ /T1_0 1 Tf 16.383 0 Td [(day)-210(0)]TJ /T1_1 1 Tf 2.507 0 Td [(\))-210(that)-210(the)-210(food)]TJ -18.89 -1.1 Td [(was)-387(switched)-387(from)-387(low)-387(salt)-387(to)-387(high)-387(salt.)-332(As)-387(shown)-387(in)]TJ T* [(Fig.)-537(3,)-537(the)-537(blood)-537(pressure)-537(increased)-537(from)-537(a)-537(control)]TJ T* [(value)-321(of)-321(133.1)]TJ /T1_2 1 Tf 6.816 0 Td (6)Tj /T1_1 1 Tf 1.154 0 Td [(2.9)-321(to)-321(145.9)]TJ /T1_2 1 Tf 5.743 0 Td (6)Tj /T1_1 1 Tf 1.154 0 Td [(3.7)-321(mmHg)-321(on)-321(the)-321(\256rst)]TJ -14.866 -1.1 Td [(day)-588(of)-588(high)-588(salt.)-588(It)-588(continued)-588(to)-588(rise)-588(and)-588(reached)]TJ 0 -1.1 TD (165.2)Tj /T1_2 1 Tf 2.756 0 Td (6)Tj /T1_1 1 Tf 1.087 0 Td [(2.8)-254(mmHg)-254(on)]TJ /T1_0 1 Tf 6.411 0 Td [(day)-254(4)]TJ /T1_1 1 Tf 2.495 0 Td [(.)-199(All)-254(the)-254(pressures)-254(during)-254(4)]TJ -12.748 -1.1 Td [(days)-384(of)-384(high)-384(salt)-384(were)-384(signi\256cantly)-384(higher)-384(than)-384(their)]TJ T* [(control)-430(values,)-430(and)-430(the)-430(net)-430(increase)-430(in)-430(pressure)-430(was)]TJ T* [(32.1)-362(mmHg)-362(from)-362(the)-362(control.)-362(The)-362(high)-362(salt)-362(plus)-362(body)]TJ T* [(weight)-303(control)-303(caused)-303(plasma)-303(sodium)-303(concentration)-303(to)]TJ -26.4 -2.9 Td [(T)62(able)-250(1.)]TJ /T1_0 1 Tf 4.116 0 Td [(A)20(verage)-250(of)-250(MAP)129(,)-250([Na)]TJ /T1_2 1 Tf 6.486 0 1.006 6.486 183.565 189.006 Tm (1)Tj /T1_0 1 Tf 9.978 0 0 9.978 189.523 186.012 Tm [(]p,)-250(body)-250(weight)-250(gain,)-250(salt)-250(and)-250(water)-250(intake)-250(for)-250(all)-250(5)-250(groups)-250(of)-250(rats)]TJ -14.127 -1.1 Td [(during)-250(4)-250(days)-250(of)-250(control)]TJ ET 0 0 0 1 K 0.499 w 10 M 0 j 0 J []0 d 48.569 169.257 m 563.431 169.257 l 48.569 166.762 m 563.431 166.762 l 48.569 76.921 m 563.431 76.921 l 160.781 151.027 m 550.04 151.027 l 48.569 128.307 m 563.431 128.307 l S BT /T1_1 1 Tf 6.985 0 0 6.985 86.213 133.546 Tm (Groups)Tj 27.819 3.253 Td [(A)74(verage)-250(of)-250(Control)-250(Measurements)-250(\(0.2%)-250(NaCl\))]TJ -15.686 -2.11 Td [(S,)-250(4%)-250(NaCl,)]TJ -1.457 -1.143 Td [(no)-250(body)-250(wt)-250(control)]TJ 13.423 1.143 Td [(S,)-250(4%)-250(NaCl,)]TJ /T1_2 1 Tf -1.194 -1.143 Td (1)Tj /T1_1 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ 11.91 1.143 Td [(S,)-250(0.2%)-250(NaCl,)]TJ -1.041 -1.143 Td [(no)-250(body)-250(wt)-250(control)]TJ 13.007 1.143 Td [(S,)-250(0.2%)-250(NaCl,)]TJ /T1_2 1 Tf -0.777 -1.143 Td (1)Tj /T1_1 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ 12.017 1.143 Td [(R,)-250(4%)-250(NaCl,)]TJ /T1_2 1 Tf -1.148 -1.143 Td (1)Tj /T1_1 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ 7.982 0 0 7.982 61.96 118.08 Tm [(MAP)129(,)-249(mmHg)-7173(125.0)]TJ /T1_2 1 Tf 15.665 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(4.8*)-5023(133.1)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(2.9*)-5023(135.3)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(6.7*)-5273(137.1)]TJ /T1_2 1 Tf 9.776 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(3.9*)-4792(107.6)]TJ /T1_2 1 Tf 9.295 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td (2.6)Tj -58.509 -1.125 Td ([Na)Tj /T1_2 1 Tf 5.488 0 0 5.488 75.56 111.594 Tm (1)Tj /T1_1 1 Tf 7.982 0 0 7.982 80.577 109.1 Tm [(]p,)-249(meq/l)-6748(142.3)]TJ /T1_2 1 Tf 13.333 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.2*)-5023(142.2)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.3*)-5023(142.6)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.3*)-5273(142.6)]TJ /T1_2 1 Tf 9.776 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.2*)-4792(145.4)]TJ /T1_2 1 Tf 9.295 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td (1.2)Tj -58.509 -1.125 Td [(Body)-249(wt)-249(gain,)-249(g/day)-5137(6.1)]TJ /T1_2 1 Tf 15.665 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.4)-6634(4.8)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.6)-6634(4.0)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.8)-6884(5.5)]TJ /T1_2 1 Tf 9.776 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.9)-6404(3.0)]TJ /T1_2 1 Tf 9.295 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td (0.8)Tj -58.509 -1.125 Td [(Salt)-249(in,)-249(meq/day)-6126(0.90)]TJ /T1_2 1 Tf 15.665 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.05*)-5023(0.92)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.06*)-5023(0.86)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.06*)-5273(0.80)]TJ /T1_2 1 Tf 9.776 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.08)-5292(0.73)]TJ /T1_2 1 Tf 9.295 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td (0.06)Tj -58.509 -1.125 Td [(W)74(ater)-249(in,)-249(ml/day)-5961(24.8)]TJ /T1_2 1 Tf 15.665 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(1.6)-6079(26.9)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(1.2)-6079(25.5)]TJ /T1_2 1 Tf 9.526 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(1.6)-6329(26.1)]TJ /T1_2 1 Tf 9.776 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td [(0.8)-5848(26.0)]TJ /T1_2 1 Tf 9.295 0 Td (6)Tj /T1_1 1 Tf 0.944 0 Td (1.1)Tj -59.187 -1.933 Td [(V)92(alues)-307(are)-307(means)]TJ /T1_2 1 Tf 8.514 0 Td (6)Tj /T1_1 1 Tf 1.14 0 Td [(SE.)-307(*)-111(Signi\256cantly)-307(di)10(f)28(ferent)-307(from)-307(value)-307(of)-307(SR/Jr)-307(\(R\))-307(group)-307(\()]TJ /T1_0 1 Tf 27.368 0 Td (P)Tj /T1_2 1 Tf 0.778 0 Td (,)Tj /T1_1 1 Tf 0.944 0 Td [(0.05\).)-307(S,)-307(SS/Jr;)-307(MAP)129(,)-307(mean)-307(arterial)-307(pressure;)-307([Na)]TJ /T1_2 1 Tf 5.488 0 0 5.488 549.133 69.222 Tm (1)Tj /T1_1 1 Tf 7.982 0 0 7.982 554.15 66.728 Tm (]p,)Tj -63.337 -1.125 Td [(plasma)-233(sodium)-233(concentration.)]TJ 9.978 0 0 9.978 48.569 744.772 Tm (R1394)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_5 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_5 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_5 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 131 0 obj<> endobj 132 0 obj<> endobj 133 0 obj[131 0 R] endobj 134 0 obj<> endobj 138 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.978 0 0 9.978 48.569 343.137 Tm [(increase)-613(from)-613(the)-613(control)-613(of)-613(142.2)]TJ /T1_1 1 Tf 17.715 0 Td (6)Tj /T1_0 1 Tf 1.446 0 Td [(0.3)-613(meq/l)-613(to)]TJ -19.161 -1.1 Td [(signi\256cantly)-240(higher)-240(levels)-240(of)-240(145.2)]TJ /T1_1 1 Tf 15.888 0 Td (6)Tj /T1_0 1 Tf 1.073 0 Td [(0.7)-240(meq/l)-240(on)]TJ /T1_2 1 Tf 5.76 0 Td [(day)-240(2)]TJ /T1_0 1 Tf -22.721 -1.1 Td [(and)-523(146.8)]TJ /T1_1 1 Tf 5.289 0 Td (6)Tj /T1_0 1 Tf 1.356 0 Td [(0.8)-523(meq/l)-523(on)]TJ /T1_2 1 Tf 6.609 0 Td [(day)-523(3)]TJ /T1_0 1 Tf 3.288 0 Td [(of)-523(the)-523(test.)-523(These)]TJ -16.542 -1.1 Td [(increases)-235(in)-235(blood)-235(pressure)-235(and)-235(plasma)-235(sodium)-235(concen-)]TJ 0 -1.1 TD [(tration)-331(were)-331(not)-331(di)10(f)28(ferent)-331(from)-331(those)-331(of)-331(the)-331(SS/Jr)-331(rats)]TJ 0 -1.1 TD [(that)-276(were)-276(on)-276(high)-276(salt)-276(but)-276(without)-276(body)-276(weight)-276(control)]TJ T* [(\(Fig.)-318(2\).)-318(Body)-318(weight)-318(increased)-318(on)-318(a)-318(daily)-318(basis)-318(over)-318(4)]TJ T* [(days)-211(of)-211(low)-211(salt,)-211(but)-211(of)-211(course)-211(the)-211(body)-211(weight)-211(remained)]TJ T* [(essentially)-280(constant)-280(over)-280(4)-280(days)-280(of)-280(high)-280(salt)-280(because)-280(of)]TJ T* [(the)-268(e)10(f)28(f)28(icient)-268(feedback)-268(control)-268(of)-268(body)-268(weight.)-268(Changing)]TJ T* [(food)-341(from)-341(low)-341(salt)-341(to)-341(high)-341(salt)-341(resulted)-341(in)-341(an)-341(approxi-)]TJ T* [(mate)-251(14.6-fold)-251(increase)-251(in)-251(daily)-251(salt)-251(consumption,)-251(even)]TJ T* [(though)-259(total)-259(daily)-259(food)-259(consumption)-259(decreased)-259(by)-259(25%.)]TJ T* [(W)74(ater)-559(intake)-559(increased)-559(from)-559(26.9)]TJ /T1_1 1 Tf 17.075 0 Td (6)Tj /T1_0 1 Tf 1.392 0 Td [(1.2)-559(to)-559(50.9)]TJ /T1_1 1 Tf 5.903 0 Td (6)Tj /T1_0 1 Tf -24.37 -1.1 Td [(3.5)-233(ml/day)-233(in)-233(response)-233(to)-233(the)-233(high)-233(salt)-233(intake.)]TJ /T1_2 1 Tf 1 -1.1 Td [(SS/Jr)-551(rats)-551(on)-551(low-salt)-551(diet,)-551(without)-551(body)-551(weight)]TJ -1 -1.1 Td (control)Tj /T1_0 1 Tf 3.184 0 Td [(.)-241(As)-296(expected,)-296(there)-296(were)-296(no)-296(changes)-296(in)-296(arterial)]TJ -3.184 -1.1 Td [(blood)-339(pressure)-339(or)-339(plasma)-339(sodium)-339(concentration)-339(in)-339(the)]TJ 0 -1.1 TD [(SS/Jr)-418(rats)-418(when)-418(on)-418(low)-418(salt)-418(for)-418(8)-418(days.)-418(Body)-418(weight)]TJ T* [(increased)-452(at)-452(a)-452(normal)-452(rate)-452(on)-452(a)-452(daily)-452(basis)-452(with)-452(an)]TJ T* [(average)-483(increase)-483(of)-483(3.8)]TJ /T1_1 1 Tf 11.618 0 Td (6)Tj /T1_0 1 Tf 1.316 0 Td [(0.4)-483(g/day)111(.)-483(Salt)-483(and)-483(water)]TJ -12.935 -1.1 Td [(intakes)-233(were)-233(similar)-233(on)-233(each)-233(of)-233(the)-233(8)-233(days)-233(\(Fig.)-233(4\).)]TJ /T1_2 1 Tf 1 -1.1 Td [(SS/Jr)-232(rats)-232(on)-232(low-salt)-232(diet,)-232(with)-232(body)-232(weight)-232(control)]TJ /T1_0 1 Tf 23.921 0 Td (.)Tj -24.921 -1.1 Td [(When)-320(the)-320(control)-320(of)-320(body)-320(weight)-320(began)-320(at)]TJ /T1_2 1 Tf 19.801 0 Td [(day)-320(0)]TJ /T1_0 1 Tf 2.881 0 Td (while)Tj 0.001 Tc -22.683 -1.1 Td [(the)-667(SS/Jr)-667(rats)-667(were)-667(continued)-667(on)-667(low)-667(salt,)-667(blood)]TJ 0.002 Tc T* [(pressure)-667(gradually)-667(increased)-667(over)-667(4)-667(days)-667(until)-667(it)]TJ 0 Tc T* [(was)-407(19)-407(mmHg)-407(higher)-407(than)-407(during)-407(the)-407(control)-407(period)]TJ 26.4 66.452 Td [(\(Fig.)-468(5\).)-468(This)-468(pressure)-468(increase)-468(was)-468(not)-468(statistically)]TJ T* [(signi\256cant.)-392(Nevertheless,)-392(a)-392(change)-392(of)-392(this)-392(magnitude)]TJ T* [(suggests)-627(that)-627(the)-627(increase)-627(in)-627(pressure)-627(could)-627(have)]TJ T* [(resulted)-389(from)-389(a)-389(greater)-389(autonomic)-389(response)-389(to)]TJ /T1_2 1 Tf 22.368 0 Td (1)Tj /T1_0 1 Tf 0.612 0 Td [(\))-389(the)]TJ -22.98 -1.1 Td [(limitation)-287(on)-287(drinking)-287(water)-287(and)]TJ /T1_2 1 Tf 15.547 0 Td (2)Tj /T1_0 1 Tf 0.612 0 Td [(\))-287(the)-287(greater)-287(hyper)18(-)]TJ -16.159 -1.1 Td [(natremia)-252(that)-252(occurred)-252(with)-252(body)-252(weight)-252(control)-252(in)-252(the)]TJ T* [(SS/Jr)-312(strain)-312(compared)-312(with)-312(the)-312(SR/Jr)74(.)-312(Plasma)-312(sodium)]TJ T* [(concentrations)-585(varied)-585(slightly)111(,)-585(but)-585(not)-585(signi\256cantly)111(,)]TJ T* [(over)-467(4)-467(days)-467(of)-467(body)-467(weight)-467(control.)-467(Body)-467(weight)-467(in-)]TJ T* [(creased)-283(as)-283(usual)-283(during)-283(the)-283(4)-283(days)-283(of)-283(control,)-283(but)-283(body)]TJ T* [(weight)-441(remained)-441(essentially)-441(constant)-441(when)-441(feedback)]TJ T* [(servo-control)-259(was)-259(started)-259(on)]TJ /T1_2 1 Tf 13.239 0 Td [(day)-259(0)]TJ /T1_0 1 Tf 2.5 0 Td [(.)-259(Salt)-259(intake)-259(was)-259(not)]TJ -15.739 -1.1 Td [(di)10(f)28(ferent)-627(on)-627(any)-627(of)-627(the)-627(8)-627(days.)-627(W)74(ater)-627(intake)-627(did,)]TJ T* [(however)74(,)-520(decrease)-520(a)-520(little)-520(in)-520(the)-520(last)-520(3)-520(days)-520(of)-520(the)]TJ T* [(control)-310(of)-310(body)-310(weight,)-310(but)-310(the)-310(decline)-310(was)-310(not)-310(signi\256-)]TJ T* (cant.)Tj /T1_2 1 Tf 1 -1.1 Td [(SR/Jr)-360(rats)-360(on)-360(high-salt)-360(diet,)-360(with)-360(body)-360(weight)-360(con-)]TJ -1 -1.1 Td (trol)Tj /T1_0 1 Tf 1.629 0 Td [(.)-574(No)-574(signi\256cant)-574(changes)-574(in)-574(arterial)-574(pressure)-574(or)]TJ -1.629 -1.1 Td [(plasma)-325(sodium)-325(concentration)-325(were)-325(found)-325(in)-325(the)-325(SR/Jr)]TJ T* [(rats)-405(when)-405(placed)-405(on)-405(4)-405(days)-405(of)-405(high-salt)-405(diet)-405(\(Fig.)-405(6\).)]TJ 0 -1.1 TD [(Body)-218(weight)-218(gain)-218(continued)-218(on)-218(a)-218(daily)-218(basis)-218(over)-218(4)-218(days)]TJ T* [(of)-317(low)-317(salt,)-317(and)-317(body)-317(weight)-317(remained)-317(constant)-317(over)-317(4)]TJ T* [(days)-476(of)-476(high)-476(salt)-476(when)-476(servo-control)-476(was)-476(instituted.)]TJ T* [(Daily)-352(salt)-352(intake)-352(increased)-352(18.2-fold)-352(from)-352(the)-352(control.)]TJ T* [(W)74(ater)-322(intake)-322(increased)-322(from)-322(a)-322(control)-322(of)-322(26.0)]TJ /T1_1 1 Tf 21.447 0 Td (6)Tj /T1_0 1 Tf 1.155 0 Td [(1.1)-322(to)]TJ -22.602 -1.1 Td (39.6)Tj /T1_1 1 Tf 2.433 0 Td (6)Tj /T1_0 1 Tf 1.32 0 Td [(2.3)-487(ml/day)-487(in)-487(response)-487(to)-487(the)-487(increased)-487(salt)]TJ -3.754 -1.1 Td [(intake.)-288(This)-288(increase)-288(in)-288(water)-288(intake)-288(was)-288(signi\256cantly)]TJ ET q 240.2098999 0 0 312.9998932 54.303299 415.0686951 cm /Im0 Do Q BT /T1_0 1 Tf 7.982 0 0 7.982 48.569 403.345 Tm [(Fig.)-418(2.)-556(Changes)-418(in)-418(mean)-418(arterial)-418(pressure)-418(\(MAP\),)-418(plasma)-418(sodium)]TJ 0 -1.125 TD [(concentration)-223(\([Na)]TJ /T1_1 1 Tf 5.488 0 0 5.488 117.006 396.859 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 121.577 394.364 Tm [(]p\),)-223(body)-223(weight)-223(\(BW\))-223(gain,)-223(salt)-223(and)-223(water)-223(intake)]TJ -9.146 -1.125 Td [(in)-300(SS/Jr)-300(rats)-300(that)-300(were)-300(on)-300(high-salt)-300(\(4%)-300(NaCl\))-300(diet)-300(while)-300(their)-300(body)]TJ T* [(weight)-435(was)-435(not)-435(controlled)-435(during)-435(4)-435(days)-435(of)-435(experiments.)-435(*)-111(Signi\256-)]TJ T* [(cantly)-233(higher)-233(than)-233(average)-233(of)-233(control)-233(measurements)-233(\()]TJ /T1_2 1 Tf 24.477 0 Td (P)Tj /T1_1 1 Tf 0.9 0 Td (,)Tj /T1_0 1 Tf 1.066 0 Td (0.05\).)Tj ET q 317.721 96.42 240.151 314.198 re W n q 240.2098999 0 0 313.9998932 317.7212067 96.4205017 cm /Im1 Do Q Q BT /T1_0 1 Tf 7.982 0 0 7.982 311.987 84.688 Tm [(Fig.)-372(3.)-556(Changes)-372(in)-372(MAP)129(,)-372([Na)]TJ /T1_1 1 Tf 5.488 0 0 5.488 422.045 87.182 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 426.617 84.688 Tm [(]p,)-372(body)-372(weight)-372(gain,)-372(salt)-372(and)-372(water)]TJ -14.36 -1.125 Td [(intake)-234(in)-234(SS/Jr)-234(rats)-234(that)-234(were)-234(on)-234(high-salt)-234(\(4%)-234(NaCl\))-234(diet)-234(while)-234(their)]TJ T* [(body)-361(weight)-361(was)-361(controlled)-361(constant)-361(during)-361(4)-361(days)-361(of)-361(experiments.)]TJ -0.03 Tc T* [(*)-53(Signi\256cantly)-217(higher)-217(than)-217(average)-217(of)-217(control)-217(measurements)-217(\()]TJ /T1_2 1 Tf 0 Tc 26.401 0 Td (P)Tj /T1_1 1 Tf 0.883 0 Td (,)Tj /T1_0 1 Tf 1.049 0 Td (0.05\).)Tj 9.978 0 0 9.978 534.05 744.772 Tm (R1395)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w 10 M 0 j 0 J []0 d /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 139 0 obj<> endobj 140 0 obj<> endobj 141 0 obj[139 0 R] endobj 142 0 obj<> endobj 146 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.978 0 0 9.978 48.569 345.175 Tm [(lower)-203(than)-203(that)-203(in)-203(the)-203(SS/Jr)-203(rats)-203(when)-203(on)-203(high)-203(salt)-203(with)]TJ 0 -1.1 TD [(their)-233(body)-233(weight)-233(controlled.)]TJ 1 -1.1 Td [(The)-496(measurements)-496(of)-496(hematocrit,)-496(plasma)-496(volume,)]TJ -0.001 Tc -1 -1.1 Td [(central)-199(venous)-199(pressure,)-199(and)-199(plasma)-199(potassium)-199(concen-)]TJ 0 Tc T* [(tration)-249(are)-249(shown)-249(in)-249(T)62(ables)-249(2)-249(and)-249(3.)-249(None)-249(of)-249(the)-249(values)]TJ 0 -1.1 TD [(for)-270(hematocrit,)-270(plasma)-270(volume,)-270(or)-270(central)-270(venous)-270(pres-)]TJ T* [(sure)-570(di)10(f)28(fered)-570(signi\256cantly)-570(in)-570(any)-570(of)-570(the)-570(conditions,)]TJ T* [(despite)-386(the)-386(marked)-386(changes)-386(in)-386(salt)-386(intake)-386(and)-386(water)]TJ T* [(consumption.)-619(There)-619(were)-619(no)-619(di)10(f)28(ferences)-619(in)-619(plasma)]TJ T* [(potassium)-280(concentration)-280(in)-280(the)-280(SR/Jr)-280(rats)-280(or)-280(the)-280(SS/Jr)]TJ T* [(rats)-237(that)-237(were)-237(on)-237(low)-237(salt)-237(\(T)62(able)-237(2\).)-237(Compared)-237(with)-237(the)]TJ T* [(4)-272(control)-272(days,)-272(however)74(,)-272(the)-272(plasma)-272(potassium)-272(concen-)]TJ T* [(tration)-265(was)-265(decreased)-265(in)-265(all)-265(of)-265(the)-265(SS/Jr)-265(rats)-265(that)-265(were)]TJ T* [(on)-233(high)-233(salt)-233(for)-233(4)-233(days)-233(\(T)62(able)-233(3\).)]TJ 1 -1.1 Td [(Figure)-293(7)-293(shows)-293(the)-293(relationship)-293(between)-293(mean)-293(arte-)]TJ -1 -1.1 Td [(rial)-472(pressure)-472(and)-472(plasma)-472(sodium)-472(concentration)-472(over)]TJ 0 -1.1 TD [(the)-253(4)-253(days)-253(of)-253(low)-253(salt)-253(and)-253(the)-253(4)-253(days)-253(of)-253(high)-253(salt)-253(for)-253(the)]TJ T* [(combined)-296(data)-296(shown)-296(in)-296(both)-296(Figs.)-296(2)-296(and)-296(3)-296(\(SS/Jr)-296(rats)]TJ T* [(with)-415(and)-415(without)-415(body)-415(weight)-415(control\).)-415(Each)-415(1-meq/l)]TJ T* [(increase)-426(in)-426(plasma)-426(sodium)-426(concentration)-426(was)-426(associ-)]TJ T* [(ated)-233(with)-233(an)-233(increase)-233(of)-233(arterial)-233(pressure)-233(of)-233(6.8)-233(mmHg.)]TJ T* [(Approximately)-317(73%)-317(of)-317(the)-317(variation)-317(in)-317(plasma)-317(sodium)]TJ T* [(concentration)-315(was)-315(associated)-315(positively)-315(with)-315(variation)]TJ T* [(in)-233(arterial)-233(pressure)-233(\()]TJ /T1_1 1 Tf 9.475 0 Td (r)Tj /T1_2 1 Tf 0.677 0 Td (5)Tj /T1_0 1 Tf 1.066 0 Td (0.85,)Tj /T1_1 1 Tf 2.457 0 Td (P)Tj /T1_2 1 Tf 0.9 0 Td (,)Tj /T1_0 1 Tf 1.066 0 Td (0.001\).)Tj /T1_3 1 Tf 7.982 0 0 7.982 48.569 74.764 Tm (DISCUSSION)Tj /T1_0 1 Tf 9.978 0 0 9.978 58.547 56.812 Tm [(In)-439(1967)-384(Arthur)-439(Guyton)-439(and)-439(Thomas)-439(Coleman)-439(\(13\))]TJ -1 -1.1 Td [(created)-474(a)-474(computer)-474(model)-474(of)-474(arterial)-474(blood)-474(pressure)]TJ 26.4 67.648 Td [(regulation)-307(based)-307(on)-307(experimentally)-307(derived)-307(character)18(-)]TJ 0 -1.1 TD [(istics)-453(of)-453(the)-453(circulation.)-453(Surprisingly)111(,)-453(the)-453(model)-453(pre-)]TJ T* [(dicted)-248(that)-248(primary)-248(increases)-248(in)-248(cardiac)-248(output)-248(or)-248(total)]TJ 0 -1.1 TD [(peripheral)-392(resistance)-392(did)-392(not)-392(result)-392(in)-392(permanent)-392(in-)]TJ T* [(creases)-366(in)-366(arterial)-366(pressure,)-366(so)-366(long)-366(as)-366(renal)-366(function)]TJ T* [(was)-204(not)-204(altered.)-204(Their)-204(model)-204(predicted)-204(that)-204(permanent,)]TJ T* [(steady-state)-460(increases)-460(in)-460(arterial)-460(pressure)-460(can)-460(occur)]TJ T* [(only)-300(as)-300(the)-300(result)-300(of)]TJ /T1_1 1 Tf 9.535 0 Td (1)Tj /T1_0 1 Tf 0.612 0 Td [(\))-300(a)-300(change)-300(in)-300(renal)-300(function)-300(that)]TJ -10.147 -1.1 Td [(operates)-437(via)-437(pressure)-437(diuresis)-437(and/or)]TJ /T1_1 1 Tf 18.163 0 Td (2)Tj /T1_0 1 Tf 0.612 0 Td [(\))-437(increases)-437(in)]TJ -18.775 -1.1 Td [(salt)-373(and)-373(water)-373(intake.)-373(Pressure)-373(diuresis)-373(refers)-373(to)-373(the)]TJ T* [(direct)-356(e)10(f)28(fect)-356(of)-356(arterial)-356(pressure)-356(on)-356(the)-356(urinary)-356(excre-)]TJ T* [(tion)-516(of)-516(salt)-516(and)-516(water)74(.)-516(That)-516(is,)-516(as)-516(the)-516(pressure)-516(in-)]TJ T* [(creases,)-377(the)-377(renal)-377(output)-377(of)-377(salt)-377(and)-377(water)-377(increases.)]TJ T* [(When)-274(the)-274(output)-274(increases)-274(above)-274(the)-274(net)-274(intake)-274(of)-274(salt)]TJ T* [(and)-301(water)74(,)-301(negative)-301(body)-301(\257uid)-301(balance)-301(occurs,)-301(causing)]TJ T* [(the)-270(extracellular)-270(\257uid)-270(volume)-270(\(ECFV\))-270(to)-270(decrease.)-270(The)]TJ T* [(decrease)-352(in)-352(body)-352(\257uids)-352(results)-352(in)-352(decreases)-352(in)-352(central)]TJ T* [(venous)-614(pressure,)-614(cardiac)-614(output,)-614(and)-614(thus)-614(arterial)]TJ T* [(pressure,)-320(which)-320(declines)-320(until)-320(the)-320(input)-320(and)-320(output)-320(of)]TJ T* [(salt)-298(and)-298(water)-298(are)-298(equal)-298(once)-298(again.)-298(Conversely)111(,)-298(if)-298(the)]TJ T* [(pressure)-201(declines)-201(below)-201(the)-201(level)-201(for)-201(balance,)-201(the)-201(intake)]TJ T* [(will)-234(be)-234(greater)-234(than)-234(output,)-234(the)-234(ECFV)-234(will)-234(expand,)-234(and)]TJ T* [(the)-398(arterial)-398(pressure)-398(will)-398(rise)-398(until)-398(input)-398(and)-398(output)]TJ T* [(are)-270(equal.)-215(Another)-270(way)-270(to)-270(state)-270(the)-270(central)-270(principle)-270(of)]TJ T* [(the)-391(Guyton-Coleman)-391(model)-391(is)-391(that)-391(an)-391(animal)-391(always)]TJ T* [(has)-337(just)-337(enough)-337(arterial)-337(pressure)-337(to)-337(keep)-337(the)-337(input)-337(of)]TJ T* [(salt)-537(and)-537(water)-537(equal)-537(to)-537(output)-537(in)-537(the)-537(steady)-537(state)]TJ T* [(\(3,)-233(12\).)]TJ 1 -1.1 Td [(In)-395(1990,)-395(Greene)-395(et)-395(al.)-395(\(1)55(1\))-395(published)-395(a)-395(critical)-395(and)]TJ -1 -1.1 Td [(thoughtful)-527(study)-527(that)-527(provided)-527(the)-527(speci\256c)-527(idea)-527(for)]TJ ET q 317.721 75.458 240.151 313.197 re W n q 240.2098999 0 0 312.9998932 317.7212067 75.4582977 cm /Im0 Do Q Q BT /T1_0 1 Tf 7.982 0 0 7.982 311.987 63.734 Tm [(Fig.)-372(5.)-556(Changes)-372(in)-372(MAP)129(,)-372([Na)]TJ /T1_2 1 Tf 5.488 0 0 5.488 422.045 66.229 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 426.617 63.734 Tm [(]p,)-372(body)-372(weight)-372(gain,)-372(salt)-372(and)-372(water)]TJ -14.36 -1.125 Td [(intake)-224(in)-224(SS/Jr)-224(rats)-224(that)-224(were)-224(on)-224(low-salt)-224(\(0.2%\))-224(diet)-224(while)-224(their)-224(body)]TJ 0 -1.125 TD [(weight)-233(was)-233(controlled)-233(constant)-233(during)-233(4)-233(days)-233(of)-233(experiments.)]TJ ET q 252 0 0 324.9998932 48.5688019 403.0610962 cm /Im1 Do Q BT /T1_0 1 Tf 7.982 0 0 7.982 48.569 391.391 Tm [(Fig.)-372(4.)-556(Changes)-372(in)-372(MAP)129(,)-372([Na)]TJ /T1_2 1 Tf 5.488 0 0 5.488 158.627 393.885 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 163.199 391.391 Tm [(]p,)-372(body)-372(weight)-372(gain,)-372(salt)-372(and)-372(water)]TJ -14.36 -1.125 Td [(intake)-224(in)-224(SS/Jr)-224(rats)-224(that)-224(were)-224(on)-224(low-salt)-224(\(0.2%\))-224(diet)-224(while)-224(their)-224(body)]TJ T* [(weight)-233(was)-233(not)-233(controlled)-233(during)-233(4)-233(days)-233(of)-233(experiments.)]TJ 9.978 0 0 9.978 48.569 744.772 Tm (R1396)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w 10 M 0 j 0 J []0 d /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 147 0 obj<> endobj 148 0 obj<> endobj 149 0 obj[147 0 R] endobj 150 0 obj<> endobj 154 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.978 0 0 9.978 48.569 353.755 Tm [(performing)-489(the)-489(present)-489(study)111(.)-489(The)-489(objective)-489(of)-489(their)]TJ 0 -1.1 TD [(study)-278(was)-278(to)-278(evaluate)-278(the)-278(Guyton-Coleman)-278(hypothesis)]TJ -0.005 Tc T* [(regarding)-195(the)-195(volume)-195(dependence)-195(of)-195(salt-induced)-195(hyper)17(-)]TJ 0 Tc T* [(tension.)-294(Their)-294(studies)-294(were)-294(conducted)-294(in)-294(outbred)-294(Dahl)]TJ T* [(S)-637(and)-637(R)-637(rats)-637(obtained)-637(from)-637(Brookhaven)-637(National)]TJ 0 -1.1 TD [(Laboratories,)-589(Uptown,)-589(NY)111(.)-589(They)-589(instrumented)-589(rats)]TJ 26.4 42.288 Td [(with)-349(chronic)-349(arterial)-349(and)-349(venous)-349(catheters)-349(and)-349(servo-)]TJ 0 -1.15 TD [(controlled)-545(body)-545(weight)-545(constant)-545(during)-545(intravenous)]TJ T* [(administration)-416(of)-416(a)-416(low-salt)-416(input)-416(\(1)-416(meq/day\))-416(and)-416(a)]TJ T* [(high-salt)-400(input)-400(\(20)-400(meq/day\))-400(for)-400(4)-400(days.)-400(Body)-400(weight)]TJ T* [(was)-228(servo-controlled)-228(at)-228(its)-228(initial)-228(value)-228(by)-228(continuously)]TJ 0 -1.15 TD [(weighing)-287(the)-287(rat)-287(on)-287(an)-287(electronic)-287(balance)-287(and)-287(infusing)]TJ T* [(water)-247(and)-247(salt)-247(intravenously)-247(at)-247(the)-247(rate)-247(of)-247(body)-247(weight)]TJ T* [(decline.)-365(W)37(ith)-365(body)-365(weight)-365(not)-365(controlled,)-365(the)-365(intrave-)]TJ T* [(nous)-317(administration)-317(of)-317(the)-317(high)-317(salt)-317(for)-317(4)-317(days)-317(caused)]TJ T* [(the)-271(body)-271(weight,)-271(plasma)-271(volume,)-271(and)-271(cardiac)-271(output)-271(of)]TJ T* [(both)-333(the)-333(Dahl)-333(S)-333(and)-333(Dahl)-333(R)-333(rats)-333(to)-333(increase,)-333(but)-333(only)]TJ T* [(the)-299(S)-299(rats)-299(exhibited)-299(increased)-299(arterial)-299(pressure)-299(on)-299(the)]TJ T* [(high)-222(salt)-222(\(27)-222(mmHg\).)-168(Arterial)-222(pressure)-222(did)-222(not)-222(increase)]TJ 0 -1.14 TD [(in)-331(the)-331(Dahl)-331(R)-331(rats)-331(because)-331(total)-331(peripheral)-331(resistance)]TJ T* [(decreased.)-243(When)-243(body)-243(weight)-243(was)-243(servo-controlled)-243(at)-243(a)]TJ T* [(constant)-233(value)-233(\(thus)-233(avoiding)-233(body)-233(\257uid)-233(volume)-233(expan-)]TJ T* [(sion\),)-373(the)-373(intravenous)-373(administration)-373(of)-373(the)-373(high)-373(salt)]TJ T* [(load)-348(did)-348(not)-348(cause)-348(the)-348(arterial)-348(pressure)-348(of)-348(the)-348(Dahl)-348(S)]TJ T* [(rats)-315(to)-315(increase.)-315(From)-315(these)-315(results,)-315(Greene)-315(et)-315(al.)-315(\(1)55(1\))]TJ 0 -1.14 TD [(concluded)-206(that)-206(`)18(`\257uid)-206(retention)-206(is)-206(required)-206(to)-206(trigger)-206(the)]TJ T* [(rise)-261(of)-261(pressure)-261(in)-261(Dahl)-261(S)-261(rats.')18(')-206(It)-261(is)-261(apparent)-261(that)-261(this)]TJ T* [(result)-222(is)-222(explicitly)-222(consistent)-222(with)-222(the)-222(Guyton-Coleman)]TJ T* [(model.)-532(That)-532(is,)-532(the)-532(blood)-532(pressure)-532(response)-532(to)-532(salt)]TJ T* [(appears)-233(to)-233(be)-233(volume)-233(dependent)-233(in)-233(Dahl)-233(S)-233(rats.)]TJ 1 -1.14 Td [(The)-339(purpose)-339(of)-339(the)-339(present)-339(study)-339(was)-339(to)-339(once)-339(again)]TJ -1 -1.14 Td [(evaluate)-250(the)-250(volume)-250(dependence)-250(of)-250(salt-induced)-250(hyper)18(-)]TJ 0 -1.14 TD [(tension)-241(in)-241(Dahl)-241(S)-241(rats.)-241(This)-241(time,)-241(however)74(,)-241(the)-241(salt)-241(and)]TJ T* [(water)-642(challenges)-642(were)-642(delivered)-642(orally)-642(while)-642(body)]TJ T* [(weight)-453(was)-453(either)-453(allowed)-453(to)-453(increase)-453(or)-453(while)-453(body)]TJ T* [(weight)-516(was)-516(held)-516(constant.)-516(Our)-516(view)-516(is)-516(that,)-516(in)-516(the)]TJ T* [(physiological)-254(sense,)-254(oral)-254(presentation)-254(of)-254(salt)-254(and)-254(water)]TJ 0 -1.14 TD [(represents)-426(a)-426(more)-426(meaningful)-426(route)-426(of)-426(delivery)-426(com-)]TJ T* [(pared)-521(with)-521(the)-521(intravenous)-521(route)-521(because)-521(no)-521(re\257ex)]TJ T* [(paths)-405(that)-405(regulate)-405(salt)-405(and)-405(water)-405(homeostasis)-405(have)]TJ T* [(been)-359(bypassed.)-359(Numerous)-359(studies)-359(have)-359(demonstrated)]TJ 0 -1.14 TD [(the)-410(potential)-410(for)-410(hepatic)-410(and)-410(gastrointestinal)-410(mecha-)]TJ T* [(nisms)-444(to)-444(in\257uence)-444(salt)-444(and)-444(water)-444(excretion)-444(\(20,)-444(23\),)]TJ T* [(although)-262(the)-262(role)-262(of)-262(the)-262(hepatic)-262(receptors)-262(in)-262(regulating)]TJ ET q 240.2098999 0 0 312.9998932 54.303299 415.0686035 cm /Im0 Do Q BT /T1_0 1 Tf 7.982 0 0 7.982 48.569 403.345 Tm [(Fig.)-372(6.)-556(Changes)-372(in)-372(MAP)129(,)-372([Na)]TJ /T1_1 1 Tf 5.488 0 0 5.488 158.627 405.839 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 163.199 403.345 Tm [(]p,)-372(body)-372(weight)-372(gain,)-372(salt)-372(and)-372(water)]TJ -14.36 -1.125 Td [(intake)-226(in)-226(SR/Jr)-226(rats)-226(that)-226(were)-226(on)-226(high-salt)-226(\(4%)-226(NaCl\))-226(diet)-226(while)-226(their)]TJ 0 -1.125 TD [(body)-233(weight)-233(was)-233(controlled)-233(constant)-233(during)-233(4)-233(days)-233(of)-233(experiments.)]TJ 9.978 0 0 9.978 48.569 267.063 Tm [(T)62(able)-250(2.)]TJ /T1_2 1 Tf 4.116 0 Td [(V)129(alues)-250(for)-250(PV)140(,)-250(CVP)129(,)-250(Hct,)-250(and)-250([K)]TJ /T1_1 1 Tf 6.486 0 1.006 6.486 232.158 270.057 Tm (1)Tj /T1_2 1 Tf 9.978 0 0 9.978 238.116 267.063 Tm [(]p)-250(for)-250(all)-250(groups)-250(of)-250(rats)-250(during)-250(4)-250(consecutive)-250(days)]TJ -18.997 -1.1 Td (\()Tj /T1_1 1 Tf 9.978 0 1.551 9.978 51.891 256.087 Tm (2)Tj /T1_2 1 Tf 9.978 0 0 9.978 60.202 256.087 Tm [(3)-250(to)-250(0\))-250(on)-250(low-salt)-250(diet)]TJ ET 0 0 0 1 K 0.499 w 10 M 0 j 0 J []0 d 48.569 250.308 m 563.431 250.308 l 48.569 247.813 m 563.431 247.813 l 48.569 73.928 m 563.428 73.928 l 48.569 224.096 m 563.428 224.096 l S BT /T1_0 1 Tf 6.985 0 0 6.985 62.751 229.334 Tm (Day)Tj 14.473 1.143 Td [(S,)-250(4%)-250(NaCl,)]TJ -1.457 -1.143 Td [(no)-250(body)-250(wt)-250(control)]TJ 13.65 1.143 Td [(S,)-250(4%)-250(NaCl,)]TJ /T1_1 1 Tf -1.194 -1.143 Td (1)Tj /T1_0 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ 12.136 1.143 Td [(S,)-250(0.2%)-250(NaCl,)]TJ -1.041 -1.143 Td [(no)-250(body)-250(wt)-250(control)]TJ 13.233 1.143 Td [(S,)-250(0.2%)-250(NaCl,)]TJ /T1_1 1 Tf -0.777 -1.143 Td (1)Tj /T1_0 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ 12.243 1.143 Td [(R,)-250(4%)-250(NaCl,)]TJ /T1_1 1 Tf -1.148 -1.143 Td (1)Tj /T1_0 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ /T1_1 1 Tf 7.982 0 1.242 7.982 63.74 213.868 Tm (2)Tj /T1_2 1 Tf 7.982 0 0 7.982 70.388 213.868 Tm (3)Tj /T1_0 1 Tf 9.668 Tc 4.233 0 Td [(P)9668(V)1685(\320\320\320\320)231(\320)]TJ 0 Tc T* (CVP)Tj /T1_1 1 Tf 6.982 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.80)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.36)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.94)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.12)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.98)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj -53.259 -1.125 Td [(Hct)-6149(36.9)]TJ /T1_1 1 Tf 9.872 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.3)-6277(38.9)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.3)-6277(43.1)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(2.0)-6277(38.5)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.5)-6046(40.4)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.7)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 189.422 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 186.928 Tm [(]p)-5169(4.63)]TJ /T1_1 1 Tf 8.133 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.09)-5721(4.72)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.21)-5721(4.65)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.10)-5775(5.1)55(1)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.07)-5490(4.47)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.12)Tj /T1_1 1 Tf 7.982 0 1.242 7.982 63.74 177.948 Tm (2)Tj /T1_2 1 Tf 7.982 0 0 7.982 70.388 177.948 Tm (2)Tj /T1_0 1 Tf 4.233 0 Td [(PV)-6982(6.3)]TJ /T1_1 1 Tf 9.872 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.4)-6833(6.3)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.5)-6833(6.2)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.2)-6833(7.6)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.3)-6602(5.2)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.1)Tj -53.259 -1.125 Td (CVP)Tj /T1_1 1 Tf 6.982 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.70)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (0.80)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.8)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.59)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (0.86)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.57)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj -53.259 -1.125 Td [(Hct)-6149(37.8)]TJ /T1_1 1 Tf 9.872 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.6)-6277(37.8)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.7)-6277(41.2)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.2)-6277(36.2)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.4)-6046(39.2)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 153.502 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 151.007 Tm [(]p)-5169(4.56)]TJ /T1_1 1 Tf 8.133 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.06)-5721(4.38)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.06)-5721(4.36)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.1)55(1)-5775(4.55)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.12)-5490(4.14)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.09)Tj /T1_1 1 Tf 7.982 0 1.242 7.982 63.74 142.027 Tm (2)Tj /T1_2 1 Tf 7.982 0 0 7.982 70.388 142.027 Tm (1)Tj /T1_0 1 Tf 9.668 Tc 4.233 0 Td [(P)9668(V)1685(\320\320\320\320)231(\320)]TJ 0 Tc T* (CVP)Tj /T1_1 1 Tf 6.982 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.40)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.2)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (0.67)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.7)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.43)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.39)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.68)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj -53.259 -1.125 Td [(Hct)-6149(37.9)]TJ /T1_1 1 Tf 9.872 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.3)-6277(38.1)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.7)-6277(42.0)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.3)-6277(36.8)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.4)-6046(40.8)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 117.581 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 115.087 Tm [(]p)-5169(4.69)]TJ /T1_1 1 Tf 8.133 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.17)-5721(4.59)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.08)-5721(4.81)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.07)-5721(4.84)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.10)-5490(4.33)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.15)Tj /T1_2 1 Tf -57.493 -1.125 Td (0)Tj /T1_0 1 Tf 9.668 Tc 4.233 0 Td [(P)9668(V)1685(\320\320\320\320)231(\320)]TJ 0 Tc T* (CVP)Tj /T1_1 1 Tf 6.982 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.00)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.24)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.7)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.98)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.41)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.2)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.97)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj -53.259 -1.125 Td [(Hct)-6149(37.9)]TJ /T1_1 1 Tf 9.872 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.1)-6277(38.5)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(2.1)-6277(40.6)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.6)-6277(37.3)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.5)-6046(39.5)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 81.66 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 79.166 Tm [(]p)-5169(4.79)]TJ /T1_1 1 Tf 8.133 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.13)-5721(4.62)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.05)-5721(4.64)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.07)-5721(4.99)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.08)-5490(4.22)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.15)Tj -59.226 -1.933 Td [(V)92(alues)-243(are)-243(means)]TJ /T1_1 1 Tf 8.323 0 Td (6)Tj /T1_0 1 Tf 1.076 0 Td [(SE)-243(in)-243(ml/100)-243(g)-243(body)-243(wt)-243(for)-243(plasma)-243(volume)-243(\(PV\),)-243(cmH)]TJ 5.488 0 0 5.488 324.835 62.487 Tm (2)Tj 7.982 0 0 7.982 327.886 63.734 Tm [(O)-243(for)-243(central)-243(venous)-243(pressure)-243(\(CVP\),)-243(%)-243(for)-243(hematocrit)-243(\(Hct\),)-243(and)]TJ -34.992 -1.125 Td [(meq/l)-282(for)-282(plasma)-282(potassium)-282(concentration)-282(\([K)]TJ /T1_1 1 Tf 5.488 0 0 5.488 216.962 57.248 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 221.978 54.754 Tm [(]p\).)-282(Body)-282(weight)-282(was)-282(not)-282(controlled)-282(in)-282(any)-282(of)-282(the)-282(groups,)-282(but)-282(headings)-282(indicate)-282(which)-282(groups)]TJ -21.724 -1.125 Td [(had)-233(body)-233(wt)-233(controlled,)-233(or)-233(not)-233(controlled,)-233(on)-233(subsequent)-233(4)-233(days)-233(\(see)-233(T)62(able)-278(3\).)]TJ 9.978 0 0 9.978 534.05 744.772 Tm (R1397)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 155 0 obj<> endobj 156 0 obj<> endobj 157 0 obj[155 0 R] endobj 158 0 obj<> endobj 162 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.978 0 0 9.978 48.569 493.121 Tm [(arterial)-550(pressure)-550(in)-550(response)-550(to)-550(changes)-550(in)-550(dietary)]TJ 0 -1.1 TD [(NaCl)-233(has)-233(been)-233(questioned)-233(\(2\).)]TJ 1 -1.1 Td [(As)-333(expected,)-334(4)-333(days)-333(of)-334(high-salt)-333(diet)-334(increased)-333(arte-)]TJ -1 -1.1 Td [(rial)-206(pressure)-206(31.4)-206(mmHg)-206(with)-206(no)-206(body)-206(weight)-206(control)-206(in)]TJ T* [(S)-385(rats)-385(\(Fig.)-385(2\).)-385(Similarly)111(,)-385(when)-385(body)-385(weight)-385(was)-385(con-)]TJ 0 -1.1 TD [(trolled)-335(at)-335(zero)-335(change,)-335(4)-335(days)-335(of)-335(salt)-335(diet)-335(produced)-335(an)]TJ T* [(increase)-409(of)-409(arterial)-409(pressure)-409(of)-409(33.3)-409(mmHg)-409(in)-409(S)-409(rats)]TJ T* [(\(Fig.)-384(3\).)-384(These)-384(data)-384(support)-384(the)-384(hypothesis)-384(that)-384(salt-)]TJ T* [(induced)-424(hypertension)-424(in)-424(S)-424(rats)-424(is)-424(not)-424(volume)-424(depen-)]TJ T* [(dent.)-257(Several)-257(other)-257(\256ndings)-257(of)-257(our)-257(study)-257(are)-257(consonant)]TJ T* [(with)-583(volume)-583(not)-583(being)-583(an)-583(obligatory)-583(step)-583(for)-583(salt-)]TJ T* [(mediated)-474(hypertension)-474(in)-474(S)-474(rats.)-474(First,)-474(body)-474(weight)]TJ T* [(was)-211(controlled)-211(very)-211(close)-211(to)-211(zero)-211(change)-211(from)-211(day)-211(to)-211(day)]TJ T* [(\(Figs.)-238(3,)-238(5,)-238(and)-238(6\).)-238(The)-238(absolute)-238(daily)-238(changes)-238(averaged)]TJ T* [(only)-426(0.283)-426(g,)-426(with)-426(a)-426(range)-426(of)]TJ /T1_1 1 Tf 14.388 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td [(0.5)-426(to)-426(0.6)-426(g.)-426(Because)]TJ -15.221 -1.1 Td [(these)-273(S)-273(rats)-273(were,)-273(on)-273(average,)-273(gaining)]TJ /T1_2 1 Tf 17.858 0 Td (,)Tj /T1_0 1 Tf 0.833 0 Td [(4.6)-273(g/day)-273(with)]TJ -18.691 -1.1 Td [(body)-338(weight)-338(not)-338(controlled,)-338(the)-338(control)-338(of)-338(body)-338(weight)]TJ 0 -1.1 TD [(at)-212(essentially)-212(zero)-212(change)-212(represents)-212(an)-212(over)-212(correction)]TJ T* [(and)-457(a)-457(decline)-457(in)-457(total)-457(body)-457(\257uid)-457(volume.)-457(Second,)-457(as)]TJ T* [(shown)-559(in)-559(T)62(able)-559(3,)-559(plasma)-559(volume,)-559(hematocrit,)-559(and)]TJ 26.4 20.9 Td [(central)-230(venous)-230(pressure)-230(did)-230(not)-230(change)-230(in)-230(response)-230(to)-230(4)]TJ 0 -1.12 TD [(days)-281(of)-281(high-salt)-281(diet)-281(in)-281(any)-281(of)-281(the)-281(groups.)-281(If)-281(volume)-281(is)]TJ T* [(an)-599(important,)-599(obligatory)-599(intermediate)-599(in)-599(the)-599(blood)]TJ T* [(pressure)-418(response)-418(to)-418(the)-418(high)-418(salt)-418(in)-418(SS/Jr)-418(rats,)-418(one)]TJ T* [(would)-331(predict)-331(a)-331(signi\256cant)-331(increase)-331(in)-331(plasma)-331(volume)]TJ 0 -1.12 TD [(and)-250(central)-250(venous)-250(pressure)-250(and)-250(a)-250(decrease)-250(in)-250(hemato-)]TJ T* [(crit)-272(\(or)-272(at)-272(least)-272(a)-272(tendency)-272(for)-272(change)-272(in)-272(one)-272(or)-272(more)-272(of)]TJ T* [(these)-341(variables\).)-341(Thus)-341(these)-341(data)-341(support)-341(the)-341(hypoth-)]TJ T* [(esis)-259(that,)-259(at)-259(least)-259(in)-259(SS/Jr)-259(rats,)-259(volume)-259(retention)-259(is)-259(not)]TJ T* [(an)-278(obligatory)-278(step)-278(in)-278(the)-278(pressure)-278(increase)-278(subsequent)]TJ T* [(to)-396(an)-396(oral)-396(increase)-396(in)-396(salt)-396(intake.)-396(Dobes)]TJ 18.766 0 Td [(\303)-65(ova)]TJ 1.546 0 Td [(\302)-507(et)-396(al.)-396(\(4\))]TJ -20.312 -1.12 Td [(also)-227(concluded)-227(that)-227(hypertension)-227(produced)-227(by)-227(a)-227(4%)-227(salt)]TJ T* [(diet)-232(can)-232(occur)-232(in)-231(SS/Jr)-232(rats)-232(\(obtained)-232(from)-231(the)-232(colony)-232(of)]TJ T* [(John)-280(Rapp)-280(at)-280(the)-280(Medical)-280(ÃÛÌÒ´«Ã½)-280(of)-280(Ohio,)-280(T)92(oledo,)-280(OH\))]TJ T* [(without)-374(expansion)-374(of)-374(intravascular)-374(or)-374(interstitial)-374(vol-)]TJ T* [(umes.)-291(Because)-291(we)-291(studied)-291(inbred)-291(Dahl)-291(rat)-291(strains)-291(and)]TJ 0 -1.12 TD [(Greene)-303(et)-303(al.)-303(\(1)55(1\))-303(used)-303(outbred)-303(Brookhaven)-303(Dahl)-303(rats,)]TJ T* [(the)-233(di)10(f)28(ference)-233(in)-233(results)-233(between)-233(the)-233(studies)-233(might)-233(also)]TJ T* [(be)-462(contributed)-462(to)-462(by)-462(genetic)-462(di)10(f)28(ferences)-462(between)-462(the)]TJ T* [(animals)-233(used.)]TJ 1 -1.12 Td [(In)-283(contrast,)-284(the)-283(data)-283(support)-283(a)-283(role)-284(for)-284(a)-283(more)-283(direct)]TJ -1 -1.12 Td [(e)10(f)28(fect)-446(of)-446(salt)-446(that)-446(in\257uences)-446(blood)-446(pressure)-446(indepen-)]TJ T* [(dent)-428(of)-428(the)-428(in\257uence)-428(of)-428(salt)-428(on)-428(volume.)-373(As)-428(shown)-428(in)]TJ T* [(Figs.)-254(2)-254(and)-254(3,)-254(blood)-254(pressure)-254(increased)-254(in)-254(response)-254(to)-254(4)]TJ T* [(days)-585(of)-585(high-salt)-585(diet)-585(only)-585(in)-585(the)-585(rats)-585(that)-585(had)-585(a)]TJ T* [(concomitant)-267(increase)-267(in)-267(the)-267(concentration)-267(of)-267(sodium)-267(in)]TJ T* [(the)-238(plasma)-238(\(SS/Jr)-238(rats)-238(with)-238(body)-238(weight)-238(controlled)-238(and)]TJ T* [(SS/Jr)-228(rats)-228(with)-228(no)-228(body)-228(weight)-228(control\).)-228(Figure)-228(7)-228(shows)]TJ T* [(the)-318(positive)-318(association)-318(between)-318(arterial)-318(pressure)-318(and)]TJ T* [(plasma)-489(sodium)-489(concentration)-489(in)-489(the)-489(SS/Jr)-489(rats)-489(that)]TJ T* [(were)-224(on)-224(high)-224(salt)-224(for)-224(4)-224(days)-224(both)-224(with)-224(and)-224(without)-224(body)]TJ T* [(weight)-454(control.)-399(Approximately)-454(73%)-454(\()]TJ /T1_3 1 Tf 17.5 0 Td (r)Tj /T1_1 1 Tf 0.898 0 Td (5)Tj /T1_0 1 Tf 1.287 0 Td [(0.85\))-454(of)-454(the)]TJ -19.684 -1.12 Td [(variation)-296(in)-296(plasma)-296(sodium)-296(concentration)-296(and)-296(arterial)]TJ T* [(pressure)-299(was)-299(associated)-299(positively)111(.)-299(Other)-299(studies)-299(have)]TJ T* [(shown)-651(that)-651(directly)-651(mediated)-651(increases)-651(in)-651(plasma)]TJ 0 -1.11 TD [(sodium)-322(can)-322(increase)-322(arterial)-322(blood)-322(pressure)-322(in)-322(rats)-322(by)]TJ T* [(mechanisms)-455(that)-455(are)-455(apparently)-455(not)-455(related)-455(to)-455(\257uid)]TJ T* [(volume)-233(changes)-233(\(4,)-233(8,)-233(9\).)]TJ 1 -1.11 Td [(The)-226(daily)-226(changes)-226(in)-226(body)-226(weight)-226(in)-226(the)-226(SS/Jr)-226(rats)-226(on)]TJ -1 -1.11 Td [(4)-271(days)-271(of)-271(low-salt)-271(diet)-271(and)-271(then)-271(4)-271(days)-271(of)-271(high-salt)-271(diet)]TJ -26.4 66.447 Td [(T)62(able)-250(3.)]TJ /T1_3 1 Tf 4.116 0 Td [(V)129(alues)-250(for)-250(PV)140(,)-250(CVP)129(,)-250(Hct,)-250(and)-250([K)]TJ /T1_1 1 Tf 6.486 0 1.006 6.486 232.158 723.818 Tm (1)Tj /T1_3 1 Tf 9.978 0 0 9.978 238.116 720.825 Tm [(]p)-250(in)-250(5)-250(groups)-250(of)-250(rats)]TJ ET 0 0 0 1 K 0.499 w 10 M 0 j 0 J []0 d 48.569 715.045 m 563.431 715.045 l 48.569 712.55 m 563.431 712.55 l 48.569 538.665 m 563.428 538.665 l 48.569 688.833 m 563.428 688.833 l S BT /T1_0 1 Tf 6.985 0 0 6.985 62.751 694.071 Tm (Day)Tj 14.473 1.143 Td [(S,)-250(4%)-250(NaCl,)]TJ -1.457 -1.143 Td [(no)-250(body)-250(wt)-250(control)]TJ 13.65 1.143 Td [(S,)-250(4%)-250(NaCl,)]TJ /T1_1 1 Tf -1.194 -1.143 Td (1)Tj /T1_0 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ 12.136 1.143 Td [(S,)-250(0.2%)-250(NaCl,)]TJ -1.041 -1.143 Td [(no)-250(body)-250(wt)-250(control)]TJ 13.233 1.143 Td [(S,)-250(0.2%)-250(NaCl,)]TJ /T1_1 1 Tf -0.777 -1.143 Td (1)Tj /T1_0 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ 12.243 1.143 Td [(R,)-250(4%)-250(NaCl,)]TJ /T1_1 1 Tf -1.148 -1.143 Td (1)Tj /T1_0 1 Tf 0.833 0 Td [(body)-250(wt)-250(control)]TJ /T1_3 1 Tf 7.982 0 0 7.982 67.065 678.606 Tm (1)Tj /T1_0 1 Tf 4.649 0 Td [(PV)-6732(6.2)]TJ /T1_1 1 Tf 9.622 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.4)-6833(6.1)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.5)-7083(6.6)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.2)-6833(7.3)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.3)-6602(5.3)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.1)Tj -53.259 -1.125 Td (CVP)Tj /T1_1 1 Tf 6.732 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.31)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (0.62)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj /T1_1 1 Tf 7.084 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.98)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.74)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.17)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj -53.259 -1.125 Td [(Hct)-5899(37.7)]TJ /T1_1 1 Tf 9.622 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.2)-6277(37.2)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(2.0)-6527(39.8)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.8)-6277(36.7)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.7)-6046(38.9)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 654.16 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 651.665 Tm [(]p)-4919(4.02)]TJ /T1_1 1 Tf 7.883 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.12*)-5221(3.94)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.08*)-5471(4.47)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.09)-5721(4.72)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.10)-5490(3.89)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.10)Tj /T1_3 1 Tf -57.909 -1.125 Td (2)Tj /T1_0 1 Tf 9.668 Tc 4.649 0 Td [(P)9668(V)1685(\320\320\320\320)231(\320)]TJ 0 Tc 0 -1.125 TD (CVP)Tj /T1_1 1 Tf 6.732 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.67)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.84)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj /T1_1 1 Tf 7.084 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.88)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.60)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.72)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj -53.259 -1.125 Td [(Hct)-5899(38.9)]TJ /T1_1 1 Tf 9.622 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.3)-6277(37.5)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.9)-6527(40.1)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.8)-6277(38.1)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.5)-6046(39.1)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (1.0)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 618.239 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 615.745 Tm [(]p)-4919(4.07)]TJ /T1_1 1 Tf 7.883 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.14*)-5221(3.91)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.09*)-5471(4.54)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.08)-5721(4.95)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.08)-5490(4.09)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.1)55(1)]TJ /T1_3 1 Tf -57.909 -1.125 Td (3)Tj /T1_0 1 Tf 9.668 Tc 4.649 0 Td [(P)9668(V)1685(\320\320\320\320)231(\320)]TJ 0 Tc T* (CVP)Tj /T1_1 1 Tf 6.732 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.45)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.22)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 7.084 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.66)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.38)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.15)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.6)Tj -53.259 -1.125 Td [(Hct)-5899(39.5)]TJ /T1_1 1 Tf 9.622 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.1)-6277(37.7)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.6)-6527(39.8)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.8)-6277(38.6)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.6)-6046(39.1)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (1.2)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 582.318 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 579.824 Tm [(]p)-4919(4.10)]TJ /T1_1 1 Tf 7.883 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.14*)-5221(3.88)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.06*)-5471(4.55)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.17)-5721(4.86)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.13)-5490(4.04)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.08)Tj /T1_3 1 Tf -57.909 -1.125 Td (4)Tj /T1_0 1 Tf 4.649 0 Td [(PV)-6732(5.9)]TJ /T1_1 1 Tf 9.622 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.5)-6833(6.5)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.8)-7083(6.7)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.4)-6833(7.2)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.3)-6602(5.5)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj -53.259 -1.125 Td (CVP)Tj /T1_1 1 Tf 6.732 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.38)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.5)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.48)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj /T1_1 1 Tf 7.639 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.4)Tj /T1_1 1 Tf 1.501 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.834 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (1.56)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.3)Tj /T1_1 1 Tf 6.603 0 Td (2)Tj /T1_0 1 Tf 0.833 0 Td (2.08)Tj /T1_1 1 Tf 2.057 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.4)Tj -53.259 -1.125 Td [(Hct)-5899(39.4)]TJ /T1_1 1 Tf 9.622 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.1)-6277(37.4)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.5)-6527(39.0)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(1.8)-6277(38.4)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.5)-6046(38.4)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (1.3)Tj -53.259 -1.125 Td ([K)Tj /T1_1 1 Tf 5.488 0 0 5.488 113.046 546.398 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 118.063 543.903 Tm [(]p)-4919(4.03)]TJ /T1_1 1 Tf 7.883 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.12*)-5221(4.07)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.1)55(1*)-5525(4.35)]TJ /T1_1 1 Tf 9.974 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.10)-5721(4.73)]TJ /T1_1 1 Tf 9.724 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td [(0.07)-5490(4.16)]TJ /T1_1 1 Tf 9.493 0 Td (6)Tj /T1_0 1 Tf 0.944 0 Td (0.08)Tj -59.226 -1.933 Td [(V)92(alues)-314(are)-314(means)]TJ /T1_1 1 Tf 8.534 0 Td (6)Tj /T1_0 1 Tf 1.147 0 Td [(SE.)-314(Units)-314(of)-314(measure)-314(are)-314(same)-314(as)-314(for)-314(T)62(able)-314(2.)-314(*)-111(Signi\256cantly)-314(di)10(f)28(ferent)-314(from)-313(values)-314(of)-314(control)-314(\()]TJ /T1_3 1 Tf 43.563 0 Td (P)Tj /T1_1 1 Tf 0.778 0 Td (,)Tj /T1_0 1 Tf 0.944 0 Td [(0.05\).)-314(Three)-314(of)-314(the)]TJ -55.967 -1.125 Td [(groups)-233(were)-233(switched)-233(to)-233(a)-233(high-salt)-233(diet)-233(with)-233(body)-233(weight)-233(either)-233(controlled)-233(or)-233(not)-233(controlled.)]TJ ET q 252 0 0 178 48.5688019 87.5167999 cm /Im0 Do Q BT /T1_0 1 Tf 7.982 0 0 7.982 48.569 75.708 Tm [(Fig.)-225(7.)-556(Linear)-225(regression)-225(of)-225(relationship)-225(between)-225(MAP)-207(and)-225([Na)]TJ /T1_1 1 Tf 5.488 0 0 5.488 279.063 78.202 Tm (1)Tj /T1_0 1 Tf 7.982 0 0 7.982 283.635 75.708 Tm [(]p)-225(in)]TJ -29.448 -1.125 Td [(SS/Jr)-369(rats)-369(that)-369(were)-369(on)-369(high-salt)-369(diet)-369(while)-369(their)-369(body)-369(weight)-369(was)]TJ T* [(either)-233(controlled)-233(or)-233(not)-233(controlled)-233(\()]TJ /T1_3 1 Tf 15.882 0 Td (r)Tj /T1_1 1 Tf 0.677 0 Td (5)Tj /T1_0 1 Tf 1.066 0 Td (0.85,)Tj /T1_3 1 Tf 2.456 0 Td (P)Tj /T1_1 1 Tf 0.899 0 Td (,)Tj /T1_0 1 Tf 1.066 0 Td (0.001\).)Tj 9.978 0 0 9.978 48.569 744.772 Tm (R1398)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 163 0 obj<> endobj 164 0 obj<> endobj 165 0 obj[163 0 R] endobj 166 0 obj<> endobj 170 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.978 0 0 9.978 48.569 720.825 Tm [(are)-491(shown)-491(in)-491(Fig.)-491(2)]TJ /T1_1 1 Tf 9.704 0 Td (C)Tj /T1_0 1 Tf 0.722 0 Td [(.)-491(Each)-491(day)-491(the)-491(rats)-491(gained)-491(on)]TJ -10.426 -1.1 Td (average)Tj /T1_2 1 Tf 4.233 0 Td (,)Tj /T1_0 1 Tf 0.833 0 Td [(5)-603(g.)-603(It)-603(is)-603(interesting)-603(that)-603(there)-603(was)-603(no)]TJ -5.066 -1.1 Td [(increase)-424(in)-424(the)-424(rate)-424(of)-424(change)-424(in)-424(body)-424(weight)-424(subse-)]TJ 0 -1.1 TD [(quent)-248(to)-248(the)-248(start)-248(of)-248(the)-248(high-salt)-248(diet,)-248(even)-248(though)-248(the)]TJ T* [(salt)-344(intake)-344(increased)]TJ /T1_2 1 Tf 10.125 0 Td (,)Tj /T1_0 1 Tf 0.833 0 Td [(18.7-fold)-344(and)-344(the)-344(water)-344(intake)]TJ -10.958 -1.1 Td [(increased)-582(almost)-582(threefold.)-582(Presumably,)-582(this)-582(means)]TJ 0 -1.1 TD [(that)-287(there)-287(was)-287(no)-287(major)-287(change)-287(in)-287(total)-287(body)-287(\257uid)-287(and)]TJ T* [(that)-389(the)-389(increased)-389(water)-389(intake)-389(was)-389(excreted)-389(rapidly)]TJ T* [(with)-316(no)-316(change)-316(in)-316(water)-316(balance)-316(from)-316(day)-316(to)-316(day)-316(\(17\).)]TJ T* [(This)-590(result)-590(is)-590(consistent)-590(with)-590(a)-590(lack)-590(of)-590(signi\256cant)]TJ T* [(change)-620(in)-620(plasma)-620(volume,)-620(hematocrit,)-620(and)-620(central)]TJ T* [(venous)-282(pressure.)-282(Presumably,)-282(the)-282(15.8-mmHg)-282(increase)]TJ T* [(in)-426(arterial)-426(pressure)-426(that)-426(occurred)-426(on)-426(the)-426(\256rst)-426(day)-426(of)]TJ T* [(high-salt)-317(diet)-317(\(Fig.)-317(2\))-317(was)-317(one)-317(of)-317(the)-317(mechanisms)-317(that)]TJ T* [(allowed)-475(a)-475(rapid)-475(excretion)-475(of)-475(water)-475(such)-475(that)-475(we)-475(re-)]TJ T* [(corded)-233(no)-233(change)-233(in)-233(the)-233(rate)-233(of)-233(body)-233(weight)-233(gain)-233(\(28\).)]TJ 1 -1.1 Td [(The)-333(role)-333(of)-333(volume)-333(expansion)-333(in)-333(the)-333(development)-333(of)]TJ -1 -1.1 Td [(hypertension)-253(was)-253(originally)-253(predicted)-253(from)-253(a)-253(computer)]TJ 0 -1.1 TD [(model)-407(of)-407(the)-407(circulation)-407(\(13,)-407(14\).)-407(Guyton')37(s)-407(laboratory)]TJ T* [(produced)-336(evidence)-336(for)-336(the)-336(role)-336(of)-336(volume)-336(expansion)-336(in)]TJ T* [(hypertension)-207(by)-207(demonstrating)-207(that)-207(body)-207(\257uid)-207(volumes)]TJ T* [(and)-228(cardiac)-228(output)-228(increased)-228(along)-228(with)-228(blood)-228(pressure)]TJ T* [(during)-214(the)-214(development)-214(of)-214(hypertension)-214(\(for)-214(review)92(,)-214(see)]TJ T* [(Ref.)-206(15\).)-206(However)74(,)-206(other)-206(laboratories)-206(that)-206(examined)-206(the)]TJ T* [(sequence)-304(of)-304(changes)-304(in)-304(blood)-304(pressure,)-304(cardiac)-304(output,)]TJ T* [(and)-264(blood)-264(volume)-264(during)-264(the)-264(development)-264(of)-264(hyperten-)]TJ T* [(sion)-278(have)-278(observed)-278(contradictory)-278(results.)-278(For)-278(example,)]TJ T* [(Fletcher)-524(et)-524(al.)-524(\(6\))-524(and)-524(Kaneko)-524(et)-524(al.)-524(\(18\))-524(found)-524(no)]TJ T* [(relationship)-358(between)-358(the)-358(development)-358(of)-358(renal)-358(hyper)18(-)]TJ T* [(tension)-354(and)-354(changes)-354(in)-354(cardiac)-354(output.)-354(Ferrario)-354(et)-354(al.)]TJ 0 -1.1 TD [(\(5\))-446(and)-446(Freeman)-446(et)-446(al.)-446(\(7\))-446(observed)-446(that)-446(renal)-446(wrap)]TJ 0 -1.1 TD [(hypertension)-555(developed)-555(in)-555(dogs)-555(without)-555(changes)-555(in)]TJ T* [(plasma)-503(volume)-503(or)-503(mean)-503(circulatory)-503(\256lling)-503(pressure.)]TJ T* [(Korner)-465(\(19\))-465(has)-465(reviewed)-465(other)-465(evidence)-465(that)-465(is)-465(not)]TJ T* [(consistent)-250(with)-250(the)-250(concept)-250(that)-250(hypertension)-250(develops)]TJ T* [(as)-363(a)-363(result)-363(of)-363(a)-363(volume-dependent)-363(increase)-363(in)-363(cardiac)]TJ T* (output.)Tj 1 -1.1 Td [(Other)-250(than)-250(our)-250(study)111(,)-250(we)-250(are)-250(aware)-250(of)-250(only)-250(two)-250(other)]TJ -1 -1.1 Td [(studies)-285(in)-285(which)-285(body)-285(\257uid)-285(volumes)-285(were)-285(manipulated)]TJ T* [(directly)-275(to)-275(test)-275(the)-275(volume)-275(dependence)-275(of)-275(hypertension)]TJ T* [(in)-302(conscious)-302(animals.)-302(One)-302(study)-302(is)-302(the)-302(work)-302(of)-302(Greene)]TJ T* [(et)-641(al.)-641(\(1)55(1\))-641(cited)-641(previously)111(.)-641(The)-641(other)-641(study)111(,)-641(from)]TJ T* [(Guyton')37(s)-407(laboratory)-407(\(25\),)-407(manipulated)-407(body)-407(\257uid)-407(vol-)]TJ T* [(umes)-474(and)-474(plasma)-474(sodium)-474(concentration)-474(in)-474(sheep)-474(by)]TJ T* [(dialysis,)-343(nephrectomy)111(,)-343(and)-343(mineralocorticoid)-343(adminis-)]TJ T* [(tration.)-178(Although)-233(both)-233(these)-233(studies)-233(concluded)-233(that)-233(the)]TJ T* [(development)-637(of)-637(hypertension)-637(is)-637(volume)-637(dependent,)]TJ T* [(they)-372(were)-372(both)-372(more)-372(invasive)-372(than)-372(the)-372(present)-372(work.)]TJ T* [(Our)-636(data,)-636(obtained)-636(from)-636(intact,)-636(conscious)-636(animals)]TJ T* [(ingesting)-515(salt-containing)-515(chow)92(,)-515(appear)-515(to)-515(refute)-515(the)]TJ -0.003 Tc T* [(role)-197(of)-197(volume)-197(expansion)-197(in)-197(the)-197(Guyton-Coleman)-197(model.)]TJ /T1_1 1 Tf 0 Tc 0 -1.949 TD (Perspectives)Tj /T1_0 1 Tf 1 -1.8 Td [(If)-333(volume)-333(expansion)-333(is)-333(not)-333(an)-333(obligatory)-333(step)-333(in)-333(the)]TJ -1 -1.1 Td [(development)-362(of)-362(hypertension,)-362(how)-362(can)-362(we)-362(account)-362(for)]TJ 0 -1.1 TD [(the)-306(e)10(f)28(fect)-306(of)-306(NaCl)-306(ingestion)-306(on)-306(blood)-306(pressure)-306(in)-306(SS/Jr)]TJ T* [(rats)-402(with)-402(body)-402(weight)-402(servo-controlled?)-347(A)-347(model)-402(that)]TJ T* [(can)-423(explain)-423(our)-423(observations)-423(and)-423(suggests)-423(directions)]TJ 0 -1.1 TD [(for)-233(future)-233(experiments)-233(follows.)]TJ 1 -1.1 Td [(First,)-372(from)-372(our)-372(data,)-372(an)-372(increase)-372(in)-372(NaCl)-372(intake)-372(in)]TJ -1 -1.1 Td [(SS/Jr)-278(rats)-278(with)-278(body)-278(weight)-278(servo-controlled)-278(results)-278(in)]TJ 26.4 66.449 Td [(an)-238(increase)-238(in)-238(plasma)-238(Na)]TJ /T1_3 1 Tf 6.486 0 0 6.486 427.737 723.818 Tm (1)Tj /T1_0 1 Tf 9.978 0 0 9.978 435.512 720.825 Tm [(concentration)-238(that)-238(is)-238(closely)]TJ -12.38 -1.13 Td [(correlated)-489(to)-489(the)-489(increase)-489(in)-489(arterial)-489(blood)-489(pressure)]TJ 0 -1.13 TD [(\(Fig.)-233(7\).)]TJ 1 -1.13 Td [(Second,)-296(we)-296(hypothesize)-296(that)-296(this)-296(increase)-296(in)-296(plasma)]TJ -1 -1.13 Td (Na)Tj /T1_3 1 Tf 6.486 0 0 6.486 325.666 678.725 Tm (1)Tj /T1_0 1 Tf 9.978 0 0 9.978 335.893 675.731 Tm [(concentration)-483(acts,)-484(likely)-483(via)-483(a)-483(central)-484(nervous)]TJ -2.396 -1.13 Td [(system)-586(e)10(f)28(fect,)-586(to)-586(produce)-586(a)-586(widespread)-586(increase)-586(in)]TJ T* [(sympathetic)-250(activity)111(.)-250(In)-250(addition,)-250(the)-250(increased)-250(plasma)]TJ T* (Na)Tj /T1_3 1 Tf 6.486 0 0 6.486 325.666 644.904 Tm (1)Tj /T1_0 1 Tf 9.978 0 0 9.978 337.407 641.911 Tm [(concentration)-635(is)-635(predicted)-635(to)-635(increase)-635(plasma)]TJ -2.548 -1.13 Td [(vasopressin)-510(concentration)-510(via)-510(osmoreceptor)-510(stimula-)]TJ T* [(tion.)-224(Furthermore,)-224(to)-224(the)-224(extent)-224(that)-224(blood)-224(volume)-224(may)]TJ T* [(be)-526(decreased)-526(by)-526(the)-526(over)-526(correction)-526(induced)-526(by)-526(the)]TJ T* [(servo-control)-339(of)-339(body)-339(weight,)-339(renin)-339(and)-339(angiotensin)-339(II)]TJ 0 -1.13 TD [(concentrations)-233(in)-233(plasma)-233(will)-233(likely)-233(increase.)]TJ 1 -1.13 Td [(Third,)-269(the)-269(increase)-269(in)-269(sympathetic)-269(activity)-269(increases)]TJ -1 -1.13 Td [(blood)-394(pressure)-394(by)-394(increasing)-394(either)-394(cardiac)-394(output)-394(or)]TJ T* [(total)-507(peripheral)-507(resistance)-507(\(TPR\))-507(or)-507(both.)-507(Increased)]TJ T* [(secretion)-214(of)-214(vasopressin)-214(and)-214(angiotensin)-214(II)-214(will)-214(contrib-)]TJ T* [(ute)-233(to)-233(the)-233(increase)-233(in)-233(TPR.)]TJ 1 -1.13 Td [(Fourth,)-415(the)-415(increase)-415(in)-415(sympathetic)-415(activity)-415(to)-415(the)]TJ -1 -1.13 Td [(kidney)-317(along)-317(with)-317(increases)-317(in)-317(vasopressin)-317(and)-317(angio-)]TJ T* [(tensin)-257(levels)-257(all)-257(act)-257(to)-257(shift)-257(the)-257(pressure-diuresis)-257(curve)]TJ T* [(to)-207(the)-207(right)-207(\(toward)-207(higher)-207(arterial)-207(pressures\),)-207(prevent-)]TJ 0 -1.13 TD [(ing)-352(the)-352(increase)-352(in)-352(arterial)-352(pressure)-352(from)-352(being)-352(dissi-)]TJ 0 -1.13 TD [(pated)-233(by)-233(pressure)-233(diuresis.)]TJ 1 -1.13 Td [(The)-329(fourth)-329(step)-329(in)-329(the)-329(model)-329(is)-329(essential,)-329(because)-329(if)]TJ -1 -1.13 Td [(the)-206(pressure)-206(diuresis)-206(curve)-206(did)-206(not)-206(change,)-206(the)-206(increase)]TJ T* [(in)-516(arterial)-516(pressure)-516(due)-516(to)-516(the)-516(increases)-516(in)-516(cardiac)]TJ T* [(output)-428(and/or)-428(TPR)-428(will)-428(act)-428(directly)-428(on)-428(the)-428(kidney)-428(to)]TJ T* [(induce)-199(a)-199(pressure)-199(diuresis.)-199(The)-199(pressure)-199(diuresis)-199(would)]TJ T* [(then)-657(decrease)-657(plasma)-657(volume)-657(and)-657(blood)-657(pressure,)]TJ T* [(counteracting)-286(the)-286(e)10(f)28(fects)-286(of)-286(cardiac)-286(output)-286(and)-286(TPR)-286(on)]TJ T* [(blood)-233(pressure.)]TJ 1 -1.13 Td [(This)-280(model)-280(di)10(f)28(fers)-280(from)-279(Guyton)-280(and)-280(Coleman')37(s)-280(origi-)]TJ -1 -1.13 Td [(nal)-648(formulation)-648(in)-648(that)-648(an)-648(increase)-648(in)-648(body)-648(\257uid)]TJ T* [(volumes)-294(is)-294(not)-294(included)-294(as)-294(an)-294(intermediate)-294(step)-294(in)-294(the)]TJ T* [(development)-626(of)-626(hypertension.)-626(However)74(,)-626(the)-626(role)-626(of)]TJ T* [(pressure)-296(diuresis)-296(is)-296(preserved)-296(in)-296(the)-296(model.)-296(There)-296(is)-296(a)]TJ 0 -1.13 TD [(large)-295(body)-295(of)-295(evidence)-295(demonstrating)-295(that)-295(the)-295(e)10(f)28(fect)-295(of)]TJ T* [(arterial)-320(pressure)-320(on)-320(renal)-320(excretory)-320(function)-320(is)-320(intrin-)]TJ 0 -1.12 TD [(sic)-348(to)-348(the)-348(kidney)-348(\(for)-348(example,)-348(see)-348(Refs.)-348(10,)-348(27\).)-348(Thus)]TJ T* [(pressure)-340(diuresis)-340(may)-340(participate)-340(in)-340(arterial)-340(pressure)]TJ T* [(regulation,)-420(independent)-420(of)-420(changes)-420(in)-420(body)-420(\257uid)-420(vol-)]TJ T* [(umes.)-238(Furthermore,)-238(in)-238(a)-238(series)-238(of)-238(elegant)-238(studies,)-238(John)]TJ T* [(Hall)-611(and)-611(colleagues)-611(\(for)-611(review)92(,)-611(see)-611(Ref.)-611(16\))-611(have)]TJ -0.009 Tc T* [(demonstrated)-190(that)-190(increases)-190(in)-190(TPR)-190(produced)-190(by)-190(chronic)]TJ -0.001 Tc T* [(infusion)-199(of)-199(vasoconstrictor)-199(hormones)-199(produce)-199(hyperten-)]TJ 0 Tc T* [(sion)-378(only)-378(if)-378(the)-378(renal)-378(perfusion)-378(pressure)-378(is)-378(prevented)]TJ T* [(from)-493(increasing)-493(during)-493(vasoconstrictor)-493(infusion,)-493(i.e.,)]TJ T* [(only)-442(if)-442(a)-442(pressure)-442(diuresis)-442(is)-442(prevented.)-442(Hall)-442(et)-442(al.')37(s)]TJ T* [(work)-209(provides)-209(the)-209(basis)-209(for)-209(the)-209(fourth)-209(step)-209(of)-209(our)-209(model,)]TJ T* [(including)-204(pressure)-204(diuresis)-204(in)-204(a)-204(schema)-204(for)-204(the)-204(develop-)]TJ T* [(ment)-457(of)-457(hypertension)-457(that)-457(is)-457(due)-457(at)-457(least)-457(in)-457(part)-457(to)]TJ T* [(increased)-233(TPR.)]TJ 1 -1.12 Td [(In)-664(conclusion,)-664(our)-664(data)-664(provide)-664(no)-664(evidence)-664(for)]TJ -1 -1.12 Td [(volume)-272(increases)-272(operating)-272(as)-272(obligatory)-272(factors)-272(in)-272(the)]TJ T* [(arterial)-363(blood)-363(pressure)-363(response)-363(to)-363(a)-363(high-salt)-363(diet)-363(in)]TJ T* [(SS/Jr)-356(rats.)-301(A)-301(model)-356(has)-356(been)-356(proposed)-356(that)-356(preserves)]TJ T* [(the)-215(role)-215(of)-215(pressure)-215(diuresis)-215(in)-215(regulating)-215(arterial)-215(blood)]TJ T* [(pressure)-218(but)-218(does)-218(not)-218(depend)-218(on)-218(volume)-218(changes)-218(acting)]TJ T* [(as)-627(intermediates)-627(in)-627(adjusting)-627(pressure)-627(so)-627(that)-627(an)]TJ 22.255 68.851 Td (R1399)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w 10 M 0 j 0 J []0 d /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_4 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 171 0 obj<> endobj 172 0 obj<> endobj 173 0 obj[171 0 R] endobj 174 0 obj<> endobj 178 0 obj<>stream 0 0 0 1 k 1 i /GS0 gs BT /T1_0 1 Tf 0 Tc 0 Tw 0 Ts 100 Tz 0 Tr 9.978 0 0 9.978 48.569 720.825 Tm [(animal)-539(has)-539(just)-539(enough)-539(pressure)-539(to)-539(make)-539(salt)-539(and)]TJ 0 -1.1 TD [(water)-233(output)-233(equal)-233(to)-233(input.)]TJ 7.982 0 0 7.982 58.547 694.375 Tm [(This)-223(work)-223(was)-223(supported)-223(by)-223(grants)-223(to)-223(J.)-223(P)129(.)-223(Rapp)-223(from)-223(the)-223(National)]TJ -1.25 -1.125 Td [(Institutes)-453(of)-453(Health)-453(and)-453(by)-453(the)-453(Helen)-453(and)-453(Harold)-453(McMaster)-453(En-)]TJ 0 -1.125 TD [(dowed)-499(Chair)-499(in)-499(Biochemistry)-499(and)-499(Molecular)-499(Biology)111(.)-499(It)-499(was)-499(also)]TJ T* [(supported)-356(by)-356(a)-356(grant)-356(from)-356(the)-301(American)-356(Heart)-301(Association)-356(to)-356(S.)-356(L.)]TJ T* (Britton.)Tj 1.25 -1.125 Td [(Address)-576(for)-576(reprint)-576(requests)-576(and)-576(other)-576(correspondence:)-576(S.)-576(L.)]TJ -1.25 -1.125 Td [(Britton,)-209(Physiology)-209(and)-209(Molecular)-209(Medicine,)-209(Medical)-209(ÃÛÌÒ´«Ã½)-209(of)-209(Ohio,)]TJ -0.03 Tc T* [(3035)-167(Arlington)-167(A)73(ve.,)-221(T)92(oledo,)-221(OH)-221(43614-5804)-221(\(E-mail:)-221(sbritton@.mco.edu\).)]TJ 0 Tc 0 -1.625 TD [(Received)-233(30)-233(June)-233(1998;)-233(accepted)-233(in)-233(\256nal)-233(form)-233(30)-233(June)-233(1999.)]TJ /T1_1 1 Tf 0 -2.25 TD (REFERENCES)Tj /T1_0 1 Tf 0.556 -1.625 Td (1.)Tj /T1_1 1 Tf 1.39 0 Td [(Belcher)74(,)-210(E.)-210(H.,)-210(and)-210(E.)-210(B.)-210(Harris.)]TJ /T1_0 1 Tf 15.898 0 Td [(Studies)-210(of)-210(plasma)-210(volume,)-210(red)]TJ -15.898 -1.125 Td [(cell)-448(volume)-448(and)-448(total)-448(blood)-448(volume)-448(in)-448(young)-448(growing)-448(rats.)]TJ /T1_2 1 Tf 28.67 0 Td (J.)Tj -28.67 -1.125 Td [(Physiol.)-233(\(Lond.\))]TJ /T1_0 1 Tf 7.463 0 Td [(139:)-233(64)-56(\261)-56(78,)-233(1957.)]TJ -8.853 -1.125 Td (2.)Tj /T1_1 1 Tf 1.39 0 Td [(Carlson,)-615(S.)-615(H.,)-615(J.)-615(W)111(.)-615(Osborn,)-615(and)-615(J.)-615(M.)-615(W)74(yss.)]TJ /T1_0 1 Tf 25.942 0 Td (Hepatic)Tj -25.942 -1.125 Td [(denervation)-551(chronically)-551(elevates)-551(arterial)-551(pressure)-551(in)-551(W)37(istar)18(-)]TJ 0 -1.125 TD [(Kyoto)-233(rats.)]TJ /T1_2 1 Tf 5.299 0 Td (Hypertension)Tj /T1_0 1 Tf 6.322 0 Td [(32:)-233(46)-56(\261)-56(51,)-233(1998.)]TJ -13.01 -1.125 Td (3.)Tj /T1_1 1 Tf 1.39 0 Td [(Cowley)111(,)-288(A.)-288(W)111(.,)-288(Jr)74(.)]TJ /T1_0 1 Tf 8.969 0 Td [(Long-term)-288(control)-288(of)-288(arterial)-288(blood)-288(pressure.)]TJ /T1_2 1 Tf -8.969 -1.125 Td [(Physiol.)-233(Rev)37(.)]TJ /T1_0 1 Tf 6.076 0 Td [(7:)-233(231)-56(\261)-56(300,)-233(1992.)]TJ -7.465 -1.125 Td (4.)Tj /T1_1 1 Tf 1.39 0 Td (Dobes)Tj 2.75 0 Td [(\303)-83(ova)]TJ 1.778 0 Td [(\302)-139(,)-340(Z.,)-340(J.)-340(Kunes)]TJ 6.761 0 Td [(\303)-83(,)-340(and)-340(J.)-340(Zicha.)]TJ /T1_0 1 Tf 8.109 0 Td [(Body)-340(\257uid)-340(alterations)]TJ -19.397 -1.125 Td [(and)-451(organ)-451(hypertrophy)-451(in)-451(age-dependent)-451(salt)-451(hypertension)-451(of)]TJ T* [(Dahl)-233(rats.)]TJ /T1_2 1 Tf 4.855 0 Td [(Physiol.)-233(Res)]TJ /T1_0 1 Tf 5.527 0 Td [(.)-233(44:)-233(377)-56(\261)-56(387,)-233(1995.)]TJ -11.771 -1.125 Td (5.)Tj /T1_1 1 Tf 1.39 0 Td [(Ferrario,)-337(C.)-337(M.,)-337(I.)-337(H.)-337(Page,)-337(and)-337(J.)-337(W)111(.)-337(McCubbin.)]TJ /T1_0 1 Tf 25.057 0 Td (Increased)Tj -25.057 -1.125 Td [(cardiac)-462(output)-462(as)-462(a)-462(contributory)-462(factor)-462(in)-462(experimental)-462(renal)]TJ T* [(hypertension)-233(in)-233(dogs.)]TJ /T1_2 1 Tf 10.03 0 Td [(Circ.)-233(Res)]TJ /T1_0 1 Tf 4.082 0 Td [(.)-233(27:)-233(799)-56(\261)-56(810,)-233(1970.)]TJ -15.502 -1.125 Td (6.)Tj /T1_1 1 Tf 1.39 0 Td [(Fletcher)74(,)-371(P)129(.)-371(J.,)-371(P)129(.)-371(I.)-371(Korner)74(,)-371(J.)-317(A.)-317(Angus,)-371(and)-371(J.)-371(R.)-371(Oliver)74(.)]TJ /T1_0 1 Tf T* [(Changes)-216(in)-216(cardiac)-216(output)-216(and)-216(total)-216(peripheral)-216(resistance)-216(during)]TJ T* [(development)-369(of)-369(renal)-369(hypertension)-369(in)-369(the)-369(rabbit.)]TJ /T1_2 1 Tf 23.304 0 Td [(Circ.)-369(Res)]TJ /T1_0 1 Tf 4.219 0 Td [(.)-369(39:)]TJ -27.522 -1.125 Td [(633)-56(\261)-56(639,)-233(1976.)]TJ -1.39 -1.125 Td (7.)Tj /T1_1 1 Tf 1.39 0 Td [(Freeman,)-228(R.)-228(H.,)-228(J.)-228(O.)-228(Davis,)-228(and)-228(B.)-228(E.)-228(W)74(atkins.)]TJ /T1_0 1 Tf 23.463 0 Td (Development)Tj -23.463 -1.125 Td [(of)-575(chronic)-575(perinephric)-575(hypertension)-575(in)-575(dogs)-575(without)-575(volume)]TJ T* (expansion.)Tj /T1_2 1 Tf 5.244 0 Td [(Am.)-300(J.)-300(Physiol)]TJ /T1_0 1 Tf 6.747 0 Td [(.)-300(233)-300(\()]TJ /T1_2 1 Tf 2.878 0 Td [(Renal)-300(Fluid)-300(Electrolyte)-300(Physiol)]TJ /T1_0 1 Tf 14.412 0 Td (.)Tj -29.281 -1.125 Td [(2\):)-233(F278)-56(\261)-56(F281,)-233(1977.)]TJ -1.39 -1.125 Td (8.)Tj /T1_1 1 Tf 1.39 0 Td [(Friedman,)-206(S.)-206(M.,)-206(R.)-152(A.)-206(McIndoe,)-206(and)-206(M.)-206(T)62(anaka.)]TJ /T1_0 1 Tf 23.942 0 Td [(The)-206(relation)]TJ -23.942 -1.125 Td [(of)-430(blood)-430(sodium)-430(concentration)-430(to)-430(blood)-430(pressure)-430(in)-430(the)-430(rat.)]TJ /T1_2 1 Tf 28.668 0 Td (J.)Tj -28.668 -1.125 Td (Hypertens)Tj /T1_0 1 Tf 4.645 0 Td [(.)-233(8:)-233(61)-56(\261)-56(66,)-233(1990.)]TJ -6.035 -1.125 Td (9.)Tj /T1_1 1 Tf 1.39 0 Td [(Garcia-Estan,)-447(J.,)-447(L.)-447(F)111(.)-447(Carbonell,)-447(M.)-447(Garcia-Salom,)-447(F)111(.)-447(J.)]TJ T* [(Salazar)74(,)-357(and)-357(T)92(.)-357(Quesada.)]TJ /T1_0 1 Tf 13.169 0 Td [(Hemodynamic)-357(e)10(f)28(fects)-357(of)-357(hypertonic)]TJ -13.169 -1.125 Td [(saline)-233(in)-233(the)-233(conscious)-233(rat.)]TJ /T1_2 1 Tf 12.366 0 Td [(Life)-233(Sci)]TJ /T1_0 1 Tf 3.453 0 Td [(.)-233(44:)-233(1343)-56(\261)-56(1350,)-233(1989.)]TJ -17.764 -1.125 Td (10.)Tj /T1_1 1 Tf 1.946 0 Td [(Girardin,)-490(E.,)-490(J.)-490(Caverzasio,)-490(J.)-490(Iwai,)-490(J.-P)129(.)-490(Bonjour)74(,)-490(A.)-490(F)111(.)]TJ T* [(Muller)74(,)-305(and)-250(A.)-305(Grandchamp.)]TJ /T1_0 1 Tf 14.905 0 Td [(Pressure)-305(natriuresis)-305(in)-305(isolated)]TJ -14.905 -1.125 Td [(kidneys)-632(from)-632(hypertension-prone)-632(and)-632(hypertension-resistant)]TJ T* [(rats)-233(\(Dahl)-233(rats\).)]TJ /T1_2 1 Tf 7.605 0 Td [(Kidney)-233(Int)]TJ /T1_0 1 Tf 4.842 0 Td [(.)-233(18:)-233(10)-56(\261)-56(19,)-233(1980.)]TJ -0.055 Tc -14.393 -1.125 Td [(11)-55(.)]TJ /T1_1 1 Tf 0 Tc 1.891 0 Td [(Greene,)-344(A.)-344(S.,)-344(Z.)-308(Y)111(.)-308(Y)92(u,)-344(R.)-344(J.)-344(Roman,)-344(and)-344(A.)-344(W)111(.)-344(Cowley)111(,)-344(Jr)74(.)]TJ /T1_0 1 Tf T* [(Role)-360(of)-360(blood)-360(volume)-360(expansion)-360(in)-360(Dahl)-360(rat)-360(model)-360(of)-360(hyperten-)]TJ T* (sion.)Tj /T1_2 1 Tf 2.48 0 Td [(Am.)-313(J.)-313(Physiol)]TJ /T1_0 1 Tf 6.774 0 Td [(.)-313(258)-313(\()]TJ /T1_2 1 Tf 2.905 0 Td [(Heart)-313(Circ.)-313(Physiol)]TJ /T1_0 1 Tf 8.882 0 Td [(.)-313(27\):)-313(H508)-56(\261)-56(H514,)]TJ -21.041 -1.125 Td (1990.)Tj -1.891 -1.125 Td (12.)Tj /T1_1 1 Tf 1.946 0 Td [(Guyton,)-293(A.)-293(C.)]TJ /T1_0 1 Tf 7.099 0 Td [(The)-293(surprising)-293(kidney-\257uid)-293(mechanism)-293(for)-293(pres-)]TJ -7.099 -1.125 Td [(sure)-233(control\320its)-233(in\256nite)-233(gain!)]TJ /T1_2 1 Tf 13.984 0 Td (Hypertension)Tj /T1_0 1 Tf 6.322 0 Td [(16:)-233(725)-56(\261)-56(730,)-233(1990.)]TJ 10.749 58.5 Td (13.)Tj /T1_1 1 Tf 1.946 0 Td [(Guyton,)-224(A.)-224(C.,)-224(and)-224(T)92(.)-224(G.)-224(Coleman.)]TJ /T1_0 1 Tf 16.903 0 Td [(Long-term)-224(regulation)-224(of)-224(the)]TJ -16.904 -1.125 Td [(circulation:)-199(interrelationships)-199(with)-199(body)-199(\257uid)-199(volumes.)-199(In:)]TJ /T1_2 1 Tf 26.689 0 Td (Physi-)Tj -26.689 -1.125 Td [(cal)-406(Bases)-406(of)-406(Circulatory)-406(T)89(ransport,)-406(Regulation,)-406(and)-406(Exchange)]TJ /T1_0 1 Tf 29.28 0 Td (,)Tj -29.28 -1.125 Td [(edited)-563(by)-563(E.)-563(B.)-563(Reeve)-563(and)-563(A.)-563(C.)-563(Guyton.)-563(Philadelphia,)-563(P)74(A:)]TJ T* [(Saunders,)-233(1967,)-233(p.)-233(179)-56(\261)-56(201.)]TJ -1.945 -1.125 Td (14.)Tj /T1_1 1 Tf 1.946 0 Td [(Guyton,)-209(A.)-209(C.,)-209(T)92(.)-209(G.)-209(Coleman,)-209(and)-209(H.)-209(J.)-209(Granger)74(.)]TJ /T1_0 1 Tf 24.057 0 Td (Circulation:)Tj -24.057 -1.125 Td [(overall)-233(regulation.)]TJ /T1_2 1 Tf 8.687 0 Td [(Annu.)-233(Rev)37(.)-233(Physiol)]TJ /T1_0 1 Tf 8.612 0 Td [(.)-233(34:)-233(13)-56(\261)-56(46,)-233(1972.)]TJ -19.245 -1.125 Td (15.)Tj /T1_1 1 Tf 1.946 0 Td [(Guyton,)-275(A.)-275(C.,)-275(R.)-275(D.)-275(Manning,)-275(Jr)74(.,)-275(J.)-275(E.)-275(Hall,)-275(R.)-220(A.)-275(Norman,)]TJ T* [(Jr)74(.,)-453(D.)-453(B.)-416(Y)111(oung,)-453(and)-416(Y)111(.-J.)-453(Pan.)]TJ /T1_0 1 Tf 16.838 0 Td [(The)-453(pathogenic)-453(role)-453(of)-453(the)]TJ -16.838 -1.125 Td [(kidney)111(.)]TJ /T1_2 1 Tf 3.529 0 Td [(J.)-233(Cardiovasc.)-233(Pharmacol)]TJ /T1_0 1 Tf 11.832 0 Td [(.)-233(6:)-233(S151)-56(\261)-56(S161,)-233(1984.)]TJ -17.307 -1.125 Td (16.)Tj /T1_1 1 Tf 1.946 0 Td [(Hall,)-505(J.)-505(E.,)-505(H.)-505(L.)-505(Mizelle,)-505(D.)-450(A.)-505(Hildebrandt,)-505(and)-505(M.)-505(W)111(.)]TJ T* (Brands.)Tj /T1_0 1 Tf 4.545 0 Td [(Abnormal)-508(pressure)-508(natriuresis:)-508(a)-508(cause)-508(or)-508(a)-508(conse-)]TJ -4.545 -1.125 Td [(quence)-233(of)-233(hypertension?)]TJ /T1_2 1 Tf 11.251 0 Td (Hypertension)Tj /T1_0 1 Tf 6.322 0 Td [(15:)-233(547)-56(\261)-56(559,)-233(1990.)]TJ -19.518 -1.125 Td (17.)Tj /T1_1 1 Tf 1.946 0 Td [(Holtzman,)-450(E.)-450(J.,)-450(L.)-450(M.)-450(Braley)111(,)-450(G.)-450(H.)-450(W)37(illiams,)-450(and)-450(N.)-450(K.)]TJ T* (Hollenberg.)Tj /T1_0 1 Tf 6.691 0 Td [(Kinetics)-617(of)-617(sodium)-617(homeostasis)-617(in)-617(rats:)-617(rapid)]TJ -6.691 -1.125 Td [(excretion)-371(and)-371(equilibration)-371(rates.)]TJ /T1_2 1 Tf 16.077 0 Td [(Am.)-371(J.)-371(Physiol)]TJ /T1_0 1 Tf 6.89 0 Td [(.)-371(254)-371(\()]TJ /T1_2 1 Tf 3.021 0 Td (Regula-)Tj -25.987 -1.125 Td [(tory)-233(Integrative)-233(Comp.)-233(Physiol)]TJ /T1_0 1 Tf 13.861 0 Td [(.)-233(23\):)-233(R1001)-56(\261)-56(R1006,)-233(1988.)]TJ -15.806 -1.125 Td (18.)Tj /T1_1 1 Tf 1.946 0 Td [(Kaneko,)-315(Y)111(.,)-352(I.)-352(H.)-352(Page,)-352(and)-352(J.)-352(W)111(.)-352(McCubbin.)]TJ /T1_0 1 Tf 22.909 0 Td (Hemodynamic)Tj -22.909 -1.125 Td [(studies)-387(in)-387(normotensive)-387(and)-387(renal)-387(hypertensive)-387(chronic)-387(spinal)]TJ T* (dogs.)Tj /T1_2 1 Tf 2.584 0 Td [(Am.)-233(J.)-233(Physiol)]TJ /T1_0 1 Tf 6.613 0 Td [(.)-233(206:)-233(562)-56(\261)-56(566,)-233(1964.)]TJ -11.142 -1.125 Td (19.)Tj /T1_1 1 Tf 1.946 0 Td [(Korner)74(,)-387(P)129(.)-387(I.)]TJ /T1_0 1 Tf 6.718 0 Td [(Causal)-387(and)-387(homeostatic)-387(factors)-387(in)-387(hypertension.)]TJ /T1_2 1 Tf -6.718 -1.125 Td [(Clin.)-233(Sci.)-233(\(Colch.\))]TJ /T1_0 1 Tf 8.25 0 Td [(63:)-233(5s)-56(\261)-56(26s,)-233(1982.)]TJ -10.195 -1.125 Td (20.)Tj /T1_1 1 Tf 1.946 0 Td [(Meredith,)-211(T)92(.)-157(A.,)-211(P)129(.)-211(H.)-211(Brand,)-211(P)129(.)-211(J.)-211(Metting,)-211(and)-211(S.)-211(L.)-211(Britton.)]TJ /T1_0 1 Tf T* [(Hepatorenal)-406(re\257ex)-406(in)-406(the)-406(rat.)]TJ /T1_2 1 Tf 14.491 0 Td [(Can.)-406(J.)-406(Physiol.)-406(Pharmacol)]TJ /T1_0 1 Tf 12.993 0 Td [(.)-406(75:)]TJ -27.484 -1.125 Td [(1322)-56(\261)-56(1327,)-233(1997.)]TJ -1.945 -1.125 Td (21.)Tj /T1_1 1 Tf 1.946 0 Td [(Morita,)-306(H.,)-306(T)92(.)-306(Matsuda,)-306(F)111(.)-306(Furuya,)-306(M.)-306(R.)-306(Khanchowdhury)111(,)]TJ T* [(and)-323(H.)-323(Hosomi.)]TJ /T1_0 1 Tf 8.284 0 Td [(Hepatorenal)-323(re\257ex)-323(plays)-323(an)-323(important)-323(role)-323(in)]TJ -8.284 -1.125 Td [(natriuresis)-337(after)-337(high-NaCl)-337(food)-337(intake)-337(in)-337(conscious)-337(dogs.)]TJ /T1_2 1 Tf 27.342 0 Td (Circ.)Tj -27.342 -1.125 Td (Res)Tj /T1_0 1 Tf 1.629 0 Td [(.)-233(72:)-233(552)-56(\261)-56(559,)-233(1993.)]TJ -3.574 -1.125 Td (22.)Tj /T1_1 1 Tf 1.946 0 Td [(Morita,)-509(H.,)-472(Y)111(.)-509(Nishida,)-509(and)-509(H.)-509(Hosomi.)]TJ /T1_0 1 Tf 21.263 0 Td [(Neural)-509(control)-509(of)]TJ -21.263 -1.125 Td [(urinary)-409(sodium)-409(excretion)-409(during)-409(hypertonic)-409(NaCl)-409(load)-409(in)-409(con-)]TJ T* [(scious)-379(rabbits:)-379(role)-379(of)-379(renal)-379(and)-379(hepatic)-379(nerves)-379(and)-379(barorecep-)]TJ T* (tors.)Tj /T1_2 1 Tf 2.306 0 Td [(J.)-233(Auton.)-233(Nerv)37(.)-233(Syst)]TJ /T1_0 1 Tf 9.068 0 Td [(.)-233(34:)-233(157)-56(\261)-56(170,)-233(1991.)]TJ -13.32 -1.125 Td (23.)Tj /T1_1 1 Tf 1.946 0 Td [(Mu,)-457(J.,)-457(G.)-457(C.)-457(Hansson,)-457(G.)-457(Bergstro)]TJ 17.973 0 Td [(\310)-139(m,)-457(and)-457(O.)-457(Lundgren.)]TJ /T1_0 1 Tf -17.973 -1.125 Td [(Renal)-249(sodium)-248(excretion)-249(after)-249(oral)-249(or)-249(intravenous)-249(sodium)-248(loading)]TJ T* [(in)-361(sodium-deprived)-361(normotensive)-361(and)-361(spontaneously)-361(hyperten-)]TJ T* [(sive)-233(rats.)]TJ /T1_2 1 Tf 4.41 0 Td [(Acta)-233(Physiol.)-233(Scand)]TJ /T1_0 1 Tf 9.111 0 Td [(.)-233(153:)-233(169)-56(\261)-56(177,)-233(1994.)]TJ -15.467 -1.125 Td (24.)Tj /T1_1 1 Tf 1.946 0 Td [(Mu,)-254(J.,)-254(G.)-254(C.)-254(Hansson,)-254(and)-254(O.)-254(Lundgren.)]TJ /T1_0 1 Tf 20.584 0 Td [(The)-254(intestinal)-254(tract)]TJ -20.585 -1.125 Td [(and)-234(the)-234(pathophysiology)-234(of)-234(arterial)-234(hypertension.)-179(An)-234(experimen-)]TJ T* [(tal)-257(study)-257(on)-257(Dahl)-257(rats.)]TJ /T1_2 1 Tf 10.62 0 Td [(Acta)-257(Physiol.)-257(Scand)]TJ /T1_0 1 Tf 9.16 0 Td [(.)-257(155:)-257(137)-56(\261)-56(146,)-257(1995.)]TJ -21.725 -1.125 Td (25.)Tj /T1_1 1 Tf 1.946 0 Td [(Norman,)-450(R.)-396(A.,)-450(Jr)74(.,)-450(T)92(.)-450(G.)-450(Coleman,)-450(T)92(.)-450(L.)-450(W)37(iley)111(,)-450(Jr)74(.,)-450(R.)-450(D.)]TJ T* [(Manning,)-284(Jr)74(.,)-284(and)-284(A.)-284(C.)-284(Guyton.)]TJ /T1_0 1 Tf 16.441 0 Td [(Separate)-284(roles)-284(of)-284(sodium)-284(ion)]TJ -16.441 -1.125 Td [(concentration)-316(and)-316(\257uid)-316(volumes)-316(in)-316(salt-loading)-316(hypertension)-316(in)]TJ T* (sheep.)Tj /T1_2 1 Tf 3.158 0 Td [(Am.)-233(J.)-233(Physiol)]TJ /T1_0 1 Tf 6.613 0 Td [(.)-233(229:)-233(1068)-56(\261)-56(1072,)-233(1975.)]TJ -11.716 -1.125 Td (26.)Tj /T1_1 1 Tf 1.946 0 Td [(Rapp,)-257(J.)-257(P)129(.)]TJ /T1_0 1 Tf 5.644 0 Td [(Dahl)-257(salt-susceptible)-257(and)-257(salt-resistant)-257(rats.)]TJ /T1_2 1 Tf 20.788 0 Td (Hyper-)Tj -26.433 -1.125 Td (tension)Tj /T1_0 1 Tf 3.527 0 Td [(4:)-233(753)-56(\261)-56(763,)-233(1982.)]TJ -5.473 -1.125 Td (27.)Tj /T1_1 1 Tf 1.946 0 Td [(Roman,)-542(R.)-542(J.,)-542(and)-541(A.)-542(W)111(.)-542(Cowley)111(,)-542(Jr)74(.)]TJ /T1_0 1 Tf 20.092 0 Td [(Abnormal)-542(pressure-)]TJ -0.004 Tc -20.093 -1.125 Td [(diuresis-natriuresis)-195(response)-195(in)-195(spontaneously)-195(hypertensive)-195(rats.)]TJ /T1_2 1 Tf 0 Tc T* [(Am.)-297(J.)-297(Physiol)]TJ /T1_0 1 Tf 6.741 0 Td [(.)-297(248)-297(\()]TJ /T1_2 1 Tf 2.873 0 Td [(Renal)-297(Fluid)-297(Electrolyte)-297(Physiol)]TJ /T1_0 1 Tf 14.403 0 Td [(.)-297(17\):)-297(F199)-56(\261)]TJ -23.961 -1.125 Td [(F205,)-233(1985.)]TJ -2.001 -1.125 Td (28.)Tj /T1_1 1 Tf 1.946 0 Td [(Roman,)-372(R.)-372(J.,)-372(and)-372(J.)-372(L.)-372(Osborn.)]TJ /T1_0 1 Tf 16.829 0 Td [(Renal)-372(function)-372(and)-372(sodium)]TJ -16.83 -1.125 Td [(balance)-470(in)-470(conscious)-470(Dahl)-470(S)-470(and)-470(R)-470(rats.)]TJ /T1_2 1 Tf 20.055 0 Td [(Am.)-470(J.)-470(Physiol)]TJ /T1_0 1 Tf 7.087 0 Td [(.)-470(252)]TJ -27.142 -1.125 Td (\()Tj /T1_2 1 Tf 0.333 0 Td [(Regulatory)-233(Integrative)-233(Comp.)-233(Physiol)]TJ /T1_0 1 Tf 17.1 0 Td [(.)-233(21\):)-233(R833)-56(\261)-56(R841,)-233(1987.)]TJ 9.978 0 0 9.978 48.569 744.772 Tm (R1400)Tj 7.982 0 0 7.982 199.593 744.772 Tm [(MECHANISMS)-366(OF)-366(BLOOD)-366(PRESSURE)-366(REGULA)55(TION)]TJ ET 0 G 1 w 10 M 0 j 0 J []0 d /GS1 gs 588 18 16 756 re 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m 0 0 m S 0 g /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 348.9886 Tm ( on May 20, 2008 )Tj 0 0 1 rg ET /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 439.5285 Tm (ajpregu.physiology.org)Tj 0 g ET /GS1 gs BT /T1_3 1 Tf 0 -9 9 0 593 512.5543 Tm (Downloaded from )Tj ET endstream endobj 179 0 obj<>stream 1999-10-20T08:07:16Z Parlance Publisher 5.0/(Xyvision Postscript Formatter) 3.0 3 2008-05-20T06:41:58Z Acrobat Distiller 3.01 for Windows application/pdf AREGU November 46/5 uuid:a3ff07dc-1dd1-11b2-0a00-08d5e909a0b8 uuid:a3ff07e6-1dd1-11b2-0a00-00000000f090 endstream endobj xref 0 180 0000000002 00000 f 0000000016 00000 n 0000000003 00001 f 0000000013 00001 f 0000000244 00000 n 0000001252 00000 n 0000002301 00000 n 0000003348 00000 n 0000004395 00000 n 0000005326 00000 n 0000005389 00000 n 0000005526 00000 n 0000013593 00000 n 0000000014 00001 f 0000000017 00001 f 0000013835 00000 n 0000014845 00000 n 0000000018 00001 f 0000000022 00001 f 0000015068 00000 n 0000024855 00000 n 0000034107 00000 n 0000000023 00001 f 0000000027 00001 f 0000034348 00000 n 0000043407 00000 n 0000053420 00000 n 0000000028 00001 f 0000000031 00001 f 0000053672 00000 n 0000062514 00000 n 0000000032 00001 f 0000000035 00001 f 0000062744 00000 n 0000066266 00000 n 0000000036 00001 f 0000000038 00001 f 0000066508 00000 n 0000000039 00001 f 0000000041 00001 f 0000066720 00000 n 0000000042 00001 f 0000000043 00001 f 0000000111 00000 f 0000066920 00000 n 0000067095 00000 n 0000076662 00000 n 0000076839 00000 n 0000084323 00000 n 0000084510 00000 n 0000084695 00000 n 0000084878 00000 n 0000085056 00000 n 0000093519 00000 n 0000094252 00000 n 0000094985 00000 n 0000095048 00000 n 0000095271 00000 n 0000095483 00000 n 0000095581 00000 n 0000095676 00000 n 0000095840 00000 n 0000095938 00000 n 0000096032 00000 n 0000096131 00000 n 0000096221 00000 n 0000096321 00000 n 0000096406 00000 n 0000096504 00000 n 0000096595 00000 n 0000096694 00000 n 0000096781 00000 n 0000096881 00000 n 0000096963 00000 n 0000097061 00000 n 0000097156 00000 n 0000097255 00000 n 0000097346 00000 n 0000097446 00000 n 0000097532 00000 n 0000097634 00000 n 0000097728 00000 n 0000097831 00000 n 0000097921 00000 n 0000098025 00000 n 0000098110 00000 n 0000098212 00000 n 0000098304 00000 n 0000098407 00000 n 0000098495 00000 n 0000098599 00000 n 0000098682 00000 n 0000098781 00000 n 0000098862 00000 n 0000098960 00000 n 0000099050 00000 n 0000099148 00000 n 0000099223 00000 n 0000099328 00000 n 0000099383 00000 n 0000099485 00000 n 0000099547 00000 n 0000099638 00000 n 0000099730 00000 n 0000099820 00000 n 0000099916 00000 n 0000100005 00000 n 0000106000 00000 n 0000106103 00000 n 0000106165 00000 n 0000106191 00000 n 0000000112 00001 f 0000000113 00001 f 0000000119 00001 f 0000106241 00000 n 0000121055 00000 n 0000121158 00000 n 0000121220 00000 n 0000121246 00000 n 0000000120 00001 f 0000000121 00001 f 0000000127 00001 f 0000121296 00000 n 0000135837 00000 n 0000135940 00000 n 0000136002 00000 n 0000136028 00000 n 0000000128 00001 f 0000000129 00001 f 0000000135 00001 f 0000136078 00000 n 0000153085 00000 n 0000153188 00000 n 0000153250 00000 n 0000153276 00000 n 0000000136 00001 f 0000000137 00001 f 0000000143 00001 f 0000153326 00000 n 0000162432 00000 n 0000162535 00000 n 0000162597 00000 n 0000162623 00000 n 0000000144 00001 f 0000000145 00001 f 0000000151 00001 f 0000162673 00000 n 0000170739 00000 n 0000170842 00000 n 0000170904 00000 n 0000170930 00000 n 0000000152 00001 f 0000000153 00001 f 0000000159 00001 f 0000170980 00000 n 0000186047 00000 n 0000186150 00000 n 0000186212 00000 n 0000186238 00000 n 0000000160 00001 f 0000000161 00001 f 0000000167 00001 f 0000186288 00000 n 0000203014 00000 n 0000203117 00000 n 0000203179 00000 n 0000203205 00000 n 0000000168 00001 f 0000000169 00001 f 0000000175 00001 f 0000203255 00000 n 0000216380 00000 n 0000216483 00000 n 0000216545 00000 n 0000216571 00000 n 0000000176 00001 f 0000000177 00001 f 0000000000 00001 f 0000216621 00000 n 0000232702 00000 n trailer <<8FFBFEA3D11DB2110A0050DFE600A0BA>]>> startxref 234158 %%EOF